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Protein Biophysics (Prof. Daniel Otzen)

Daniel Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset

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Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  

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News

Sustainable state-of-the-art upgrade of the Danish Center for Ultrahigh-Field NMR Spectroscopy.

Thomas Vosegaard, Jørgen Skibsted, Niels Christian Nielsen, and Frans Mulder receive DKK 15 million for upgrading Nothern Europe’s most powerful NMR instrument and magnet. (Photo: AU Photo)

With a grant of DKK 15 million from the Novo Nordisk Foundation Thomas Vosegaard (Professor and iNANO Director) and co-applicants will be able to upgrade Northern Europe’s most powerful NMR instrument, and the existing hardware will be reused for a sustainable upgrade of other in-house NMR instruments. Additionally, the grant makes it possible to waive a number of external user access fees to the facilities.

Villum Synergy grants for data-driven projects at Aarhus University

Niels Christian Nielsen and Henrik Birkedal each receive a Villum Synergy grant for data-driven projects. (Photos: Lars Kruse and Lise Balsby, respectively)

Prof. Niels Christian Nielsen and Prof. Henrik Birkedal from Department of Chemistry and iNANO each receive a Villum Synergy grant for their data-driven interdisciplinary research projects. Their research projects are based on data science within optimizing sensitivity in Nuclear Magnetic Resonance (NMR) spectroscopy and improving the analysis of 3D imaging data, respectively.

Recent publications

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