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Protein Biophysics (Prof. Daniel Otzen)

Daniel Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset


Group members
Research funding

Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  

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Grants for unconventional research ideas

The Villum Foundation makes it possible for four iNANO associated researchers to test research ideas that have the potential to change our knowledge of the world.

Four iNANO-associated researchers will have a unique opportunity to test their research ideas that have the potential to change our knowledge of the…

iNANO researcher receives H.C. Ørsted research talent prize

On 16 August 2023 iNANO postdoc Mette Galsgaard Malle received one of this year's H.C. Ørsted research talent prize.

Congratulations to iNANO postdoc Mette Galsgaard Malle for receiving the H.C. Ørsted research talent prize.

Recent publications

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