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Protein Biophysics (Prof. Daniel Otzen)

Daniel Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset

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Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  

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News

Nanostructures with improved stability for the development of more effective cancer nanomedicine

Professor Kurt Gothelf is head of the Center for Multifunctional Biomolecular Drug Design (CEMBID) at Aarhus University, which is funded by the Novo Nordisk Foundation. (Photo: Lars Kruse, AU Photo)

Most drugs used today have only one mechanism of action and it is both difficult and expensive to manufacture drugs with multiple functions. Researchers at the NNF-funded research center, CEMBID, at Aarhus University have recently found a way to create more stable nanostructures that can assemble biomolecules with different functions, which in combination e.g., can provide more effective cancer medicine.

How do cells' powerhouse and nucleus communicate?: AU researcher part of new Human Frontier Science Project

Associate Professor Brigitte Stadler is one out of two researchers from Aarhus University to be awarded a Human Frontier Science Program Research Grant in 2022. (Photo: Jesper Rais, AU Photo)

AU researcher, Associate Professor Brigitte Stadler, and an intercontinental team of researchers, have received a prestigious international grant to study how important parts of the cell, the nucleus and mitochondria, communicate.

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