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Protein Biophysics (Prof. Daniel Otzen)

Daniel Erik Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset

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Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  

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News

Researchers receive Grants for unconventional research ideas

Every year The Villum Foundation’s Experiment programme supports bold and innovative research projects, and this year three researchers from iNANO…

Kurt Gothelf receives the Rozenberg Tulip Award in DNA Computing and Molecular Programming

Congratulations to Professor Kurt Vesterager Gothelf from iNANO and Department of Chemistry for receiving the Rozenberg Tulip Award.

Nickel-Catalyzed Innovation in Drug Labeling

In a major advancement for pharmaceutical science, researchers from iNANO, in collaboration with AstraZeneca and The Arctic University of Norway…

Recent publications

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