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Protein Biophysics (Prof. Daniel Otzen)

Daniel Erik Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset

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Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  

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News

Grants for projects that contributes to the Independent Green Research

Congratulations to Professor Jeppe V. Lauritsen from iNANO and Professor Bo B. Iversen from the Department of Chemistry for each receiving DKK 3.1…

3D Snapshots Unveil the Intricate Dance of RNA Folding

In a groundbreaking development, researchers from the United States and Denmark have successfully captured 3D images of individual RNA nanoparticles…

Has arginine been overlooked as a target for bioconjugation on antibodies?

A team of researchers from iNANO and Department of Chemistry have synthesized a molecule containing diketopinic acid and an azide handle which allows…

Recent publications

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