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Protein Biophysics (Prof. Daniel Otzen)

Daniel Erik Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset


Group members
Research funding

Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  

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Energy storage: Hydrogen can be packed extremely tightly in a nanoporous material

Researchers have discovered that hydrogen molecules can form penta-dihydrogen clusters in the nanoporous material, magnesium borohydride. This results in hydrogen being packed with twice the density of pure liquid hydrogen. Illustr: Nature Chemistry (6 February 2024)

Researchers at Aarhus University have discovered a porous material in which hydrogen can be packed twice as densely as in pure liquid hydrogen. This…

The CETEC Project Wins JEC Award for Circular Wind Turbine Solution

Troels Skrydstrup (Aarhus University) and the rest of the CETEC team have received the JEC Award for their groundbreaking and innovative recycling technology for wind turbine blades.

Troels Skrydstrup and the rest of the CETEC team have received the JEC Award for their groundbreaking and innovative recycling technology for wind…

Unveiling the Protective Power of Extracellular DNA Structures in Bacterial Biofilms

A team of researchers led by Professor Rikke Louise Meyer sheds light on how non-canonical DNA structures safeguard bacterial biofilms. Illustr.: Gabriel Antonio Salvador Minero

A collaborative effort between iNANO researchers and Aarhus University Hospital illuminates the mysteries of bacterial biofilms, discovering how…

Recent publications

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