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Protein Biophysics (Prof. Daniel Otzen)

Daniel Erik Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset


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Research funding

Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  

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Green methanol production: Visualizing methanol synthesis catalyst surface dynamics

A team of scientists from the Interdisciplinary Nanoscience center led by Prof. Jeppe V. Lauritsen have obtained important new insight into the industrially applied catalyst used to convert captured CO2 and H2 gas into green methanol – a key energy carrier in the replacement of fossil fuels.

A research team from iNANO, led by Prof. Jeppe V. Lauritsen, has made discoveries about the industrial catalyst used to convert captured CO₂ and H₂…

iNANO Professor joins the board of the Carlsberg Foundation

iNANO Professor Daniel Otzen as been appointed to the board of the Carlsberg Foundation. Photo: Ane Schwartz.

Professor Daniel Otzen has been appointed to the board of the Carlsberg Foundation. This prestigious role is a recognition of Professor Otzen's…

Recent publications

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