Aarhus Universitets segl

Protein Biophysics (Prof. Daniel Otzen)

Daniel Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset


Group members
Research funding

Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  

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RNA origami enables applications in synthetic biology

iNANO researchers, George Pothoulakis, Michael Nguyen, and Ebbe S. Andersen has published findings on RNA origami enabling applications in synthetic biology. Photo by Lise Refstrup Linnebjerg Pedersen (AU)

Synthetic biology strives to achieve robust control of biological processes in order to create designer organisms for a variety of industrial, diagnostic, and therapeutic applications. Researchers at the iNANO center of Aarhus University have developed RNA origami sponges and CRISPR-based regulators for advanced genetic control of enzymatic pathways in microorganisms to create a cheaper and more sustainable production of valuable biochemicals.

Recent publications

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