Aarhus Universitets segl

Protein Biophysics (Prof. Daniel Otzen)

Daniel Erik Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset


Group members
Research funding

Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  

Read more here


With new funding researchers will illuminate bacterial biofilms, advanced imaging, and quantum materials

Grants for iNANO researchers from the Carlsberg Foundation, the Novo Nordisk Foundation and Innovation Fund Denmark.

iNANO researchers secure funding for cutting-edge projects, including a landmark Semper Ardens grant for Professor Rikke Louise Meyer, unraveling the…

New chemical method advances toward targeted RNA medicine

In collaboration with Novo Nordisk researchers from Aarhus University have developed a new chemical method, which advances toward targeted RNA medicine. Illustr.: Colourbox

In close collaboration with Novo Nordisk, a novel method has been developed to enhance the synthesis of therapeutic oligonucleotides for targeted…

Researchers from iNANO and Department of Chemistry receive grants for Green Breakthrough

Researchers from iNANO and Department of Chemistry receive grants for Green Breakthrough grants. Image: Independent Research Fund Denmark

Independent Research Fund Denmark supports four research projects with researchers from iNANO and Department of Chemistry at the helm. From…

Recent publications

Sortér efter: Dato | Forfatter | Titel