Aarhus Universitets segl

Protein Biophysics (Prof. Daniel Otzen)

Daniel Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset

Facilities

News
Publications
Group members
Research funding

Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  

Read more here

News

Nanosatellite shows the way to RNA medicine of the future

"Nanosatellite explores folding space". Artist rendering by Cody Geary showing an RNA satellite exploring the possibilities for folding and applications in nanomedicine and synthetic biology.

Researchers from Aarhus University and Berkeley Laboratory have designed RNA molecules, that folds into nanoscale rectangles, cylinders, and…

Revolutionary 3D x-rays

Professor Henrik Birkedal, Professor Henning Friis Poulsen, Professor Anders Dahl, Seniorforsker Rajmund Mokso and Associate Professor Tim Dyrby.

Revolutionary x-ray sources and collaboration across disciplines will create the possibility of seeing 3D structures in the body's cells and…

Professor Dorthe Ravnsbæk receives the 2023 Elite Research Prize

Professor Dorthe Ravnsbæk receives the 2023 Elite Research Prize. Photo: Søren Kjeldgaard

Dorthe Bomholdt Ravnsbæk is one of this year's five Elite Research Prize recipients, who have been selected based on their ground-breaking,…

Recent publications

Sortér efter: Dato | Forfatter | Titel