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Protein Biophysics (Prof. Daniel Otzen)

Daniel Erik Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset

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Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  

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News

Researchers propose a roadmap towards the synthesis of life

A new perspective article by 59 international researchers, including Associate Professor Ebbe Sloth Andersen, outlines a roadmap for the synthesis of…

Integrating hydroformylations with methanol-to-syngas reforming

Researchers at Aarhus University, in collaboration with the Leibniz Institute for Catalysis, have recently demonstrated how methanol-to-syngas…

Researchers from the University of Copenhagen and Aarhus University establish new research center

Researchers at the University of Copenhagen and Aarhus University receive DKK 39.4 million from the Danish Agency for Higher Education and Science to…

Recent publications

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