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Protein Biophysics (Prof. Daniel Otzen)

Daniel Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset

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Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  

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News

Five iNANO associated researchers receive grants to promote Danish basic research

Brigitte Städler, Julián Valero Moreno, Mie Andersen, Troels Skrydstrup, and Menglin Chen are receivers of NNF-grants.

The Novo Nordisk Foundation grants a total of DKK 13.6 million to five iNANO associated researchers. The purpose of the grants is to support basic research at the highest international level. Congratulations to Brigitte Städler, Julián Valero Moreno, Mie Andersen, Troels Skrydstrup, and Menglin Chen.

How do we future-proof battery production?

On November 16, 2022, industry and academia came together to discuss challenges in connection with battery materials and their recycling at the 8th Brainnovation Day at Aarhus University

The need for energy storage is increasing, but with the present technology, there are not enough resources to produce the necessary batteries. On November 16, 2022, industry and academia came together to discuss challenges in connection with battery materials and their recycling at the 8th Brainnovation Day at Aarhus University.

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