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Protein Biophysics (Prof. Daniel Otzen)

Daniel Erik Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset


Group members
Research funding

Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  

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ENCORE project to transform nylon recycling using enzymatic processes

Professor Daniel Otzen fra iNANO, Aarhus Universitet, leder ENCORE-projektet, som modtog en bevilling på 6 millioner DKK fra Novo Nordisk Fonden. Projektet sigter mod at omdanne nylonaffald til nye produkter ved hjælp af bakterielle enzymer, hvilket reducerer behovet for fossile brændstoffer.

Professor Daniel Otzen (iNANO, Aarhus University) has been awarded a DKK 6 million Distinguished Innovator Grant by the Novo Nordisk Foundation. This…

Ken Howard elected to Controlled Release Society College of Fellows

Associate Professor Ken Howard elected to the Controlled Release Society (CRS) College of Fellows. Photo: Maria Randima, AU Photo

Associate Professor Ken Howard has been elected to the Controlled Release Society (CRS) College of Fellows. This prestigious recognition honors…

Jeppe Vang Lauritsen appointed new leader of iMAT at Aarhus University

Professor Jeppe Vang Lauritsen appointed new leader of Centre for Integrated Materials Research (iMAT) at Aarhus University. Photo: Lars Kruse, AU Photo

Professor Jeppe Vang Lauritsen has been named the new director of the Aarhus University Centre for Integrated Materials Research (iMAT). Succeeding Bo…

Recent publications

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