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Protein Biophysics (Prof. Daniel Otzen)

Daniel Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset

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Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  

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News

Cut-chemistry for a greener world

Inauguration of new center for plastic research, En'Zync, at iNANO, Aarhus University. Photo: Lise R. L. Pedersen, AU

We produce more than 400 million tonnes of plastic in the world every year. Plastic has many good functions, but we have not yet solved the big problem: What do we do with all the plastic we finish using? On January 18 a new centre for plastic research, En'Zync, were inaugurated at iNANO.

New funding for research projects and infrastructure

Henrik Birkedal, Julián Valero Moreno, Menglin Chen, Jørgen Kjems, Magnus Kjærgaard, Poul Nissen, Michael Truong-Giang Nguyen, and Nikolaj Roth could all go on Christmas holidays with the good news that they had received one or more research grants. Photo: Aarhus University

Several iNANO researchers could go on Christmas holidays with the good news that they had received one or more research grants. Congratulations to Henrik Birkedal, Julián Valero Moreno, Menglin Chen, Jørgen Kjems, Magnus Kjærgaard, Poul Nissen, Michael Truong-Giang Nguyen, and Nikolaj Roth. Thank you to the Novo Nordisk Foundation, AUFF NOVA, and the Carlsberg Foundation.

Denmark-Japan exploratory network on the molecular organization of living systems

Frans Mulder and Daniel Otzen exploring new network opportunities at Institute for Molecular Science, National Institutes of Natural Sciences (Japan).

Supported by The International Network Programme from the Danish Ministry of Higher Education and Science (UFM), scientists from iNANO are exploring new network opportunities and partnerships with researchers in Japan.

Recent publications

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