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Interdisciplinary Nanoscience Center

Biofilm group (Prof. Rikke Louise Meyer)

The group

My research combines microbiology and nanotechnology in pursuit of understanding how biofilms establish, and how they can be controlled.

Investigation of fundamental mechanisms in bacterial adhesion and biofilm formation, particularly the role of extracellular DNA.
Development of new approaches to control biofilms and treat biofilm infections through targeted drug delivery, novel antibiotics and nanobiotics, and non-biocidal biofilm control with e.g. enzymes or salinity oscillation.

2025 highligts

Ajunwa, O. M., Minero, G. A. S., Jensen, S. D. & Meyer, R. L. (2025). Hemin-binding DNA structures on the surface of bacteria promote extracellular electron transfer. Nucleic Acids Research, 53(15), Article gkaf790. https://doi.org/10.1093/nar/gkaf790

Dybtved, M. S., Petersen, M. E., Firdausy, A. F., Johansen, M. I., Faddy, E., Gadeberg, C., Østergaard, L., Jørgensen, N. P., Glud, L. N., Søgaard, A. B., Meyer, R. L. & Zelikin, A. N. (2025). Broad-Spectrum Antimicrobial Treatment Targeted Through Drug Conjugation to Vancomycin. Advanced Healthcare Materials, Article e03932. Advance online publication. https://doi.org/10.1002/adhm.202503932

Evans, D. C. S., Kristensen, M. F., Minero, G. A. S., Palmén, L. G., Knap, I., Tiwari, M. K., Schlafer, S. & Meyer, R. L. (2025). Dental biofilms contain DNase I-resistant Z-DNA and G-quadruplexes but alternative DNase overcomes this resistance. npj Biofilms and Microbiomes, 11(1), Article 80. https://doi.org/10.1038/s41522-025-00694-x

Petersen, M. E., Khamas, A. B., Østergaard, L. J., Jørgensen, N. P. & Meyer, R. L. (2025). Combination therapy delays antimicrobial resistance after adaptive laboratory evolution of Staphylococcus aureus. Antimicrobial Agents and Chemotherapy, 69(4), Article e01483-24. https://doi.org/10.1128/aac.01483-24

Del Rey, Y. C., Rikvold, P. D., Lund, M. B., Raittio, E. J., Schramm, A., Meyer, R. L. & Schlafer, S. (2025). Arginine modulates the pH, microbial composition, and matrix architecture of biofilms from caries-active patients. International Journal of Oral Science, 17(1), Article 70. https://doi.org/10.1038/s41368-025-00404-5

Recent publications

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Christiansen, S. H., Murphy, R. A., Juul-Madsen, K., Fredborg, M., Hvam, M. L., Axelgaard, E., Skovdal, S. M., Meyer, R. L., Sorensen, U. B. S., Moeller, A., Nyengaard, J. R., Norskov-Lauritsen, N., Wang, M., Gadjeva, M., Howard, K. A., Davies, J. C., Petersen, E. & Vorup-Jensen, T. (2017). The Immunomodulatory Drug Glatiramer Acetate is Also an Effective Antimicrobial Agent that Kills Gram-negative Bacteria. Scientific Reports, 7(1), Article 15653. https://doi.org/10.1038/s41598-017-15969-3

Nielsen, S. M., Nørskov-Lauritsen, N., Bjarnsholt, T. & Meyer, R. L. (2016). Achromobacter Species Isolated from Cystic Fibrosis Patients Reveal Distinctly Different Biofilm Morphotypes. Microorganisms, 4(3). https://doi.org/10.3390/microorganisms4030033

Kristensen, M. F., Meyer, R. L. & Schlafer, S. (2016). Bovine milk osteopontin - Targeting bacterial adhesion for biofilm control. Caries Research, 50, 185. Article 11. https://doi.org/10.1159/000445087

Schlafer, S., Birkedal, H., Olsen, J., Skovgaard, J., Sutherland, D., Wejse, P. L., Nyvad, B. & Meyer, R. L. (2016). Calcium-phosphate-osteopontin particles for caries control. Biofouling, 32(4), 349-357. https://doi.org/10.1080/08927014.2016.1141199

Shahavi, M. H., Hosseini, M., Jahanshahi, M., Meyer, R. L. & Darzi, G. N. (2016). Clove oil nanoemulsion as an effective antibacterial agent: Taguchi optimization method. Desalination and Water Treatment, 57(39), 18379-18390. https://doi.org/10.1080/19443994.2015.1092893

Nielsen, C. K., Kjems, J., Mygind, T., Snabe, T. & Meyer, R. L. (2016). Effects of Tween 80 on Growth and Biofilm Formation in Laboratory Media. Frontiers in Microbiology, 7(NOV), Article 1878. https://doi.org/10.3389/fmicb.2016.01878

Nielsen, C. K., Kjems, J., Mygind, T., Snabe, T., Schwarz, K., Serfert, Y. & Meyer, R. L. (2016). Enhancing the antibacterial efficacy of isoeugenol by emulsion encapsulation. International Journal of Food Microbiology, 229, 7-14. https://doi.org/10.1016/j.ijfoodmicro.2016.04.002

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Collaborations with industry

Revised 04.02.2026

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Lise Refstrup Linnebjerg Pedersen