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 iNANO About Research Groups Biofilm group (Meyer)

Biofilm group (Prof. Rikke Louise Meyer)

The group

My research combines microbiology and nanotechnology in pursuit of understanding how biofilms establish, and how they can be controlled.

  • Investigation of fundamental mechanisms in bacterial adhesion and biofilm formation, particularly the role of extracellular DNA.
  • Development of new approaches to  control biofilms and treat biofilm infections through targeted drug delivery, novel antibiotics and nanobiotics, and non-biocidal biofilm control with e.g. enzymes or salinity oscillation.

2025 highligts

Ajunwa, O. M., Minero, G. A. S., Jensen, S. D. & Meyer, R. L. (2025). Hemin-binding DNA structures on the surface of bacteria promote extracellular electron transfer. Nucleic Acids Research, 53(15), Article gkaf790. https://doi.org/10.1093/nar/gkaf790

Dybtved, M. S., Petersen, M. E., Firdausy, A. F., Johansen, M. I., Faddy, E., Gadeberg, C., Østergaard, L., Jørgensen, N. P., Glud, L. N., Søgaard, A. B., Meyer, R. L. & Zelikin, A. N. (2025). Broad-Spectrum Antimicrobial Treatment Targeted Through Drug Conjugation to Vancomycin. Advanced Healthcare Materials, Article e03932. Advance online publication. https://doi.org/10.1002/adhm.202503932

Evans, D. C. S., Kristensen, M. F., Minero, G. A. S., Palmén, L. G., Knap, I., Tiwari, M. K., Schlafer, S. & Meyer, R. L. (2025). Dental biofilms contain DNase I-resistant Z-DNA and G-quadruplexes but alternative DNase overcomes this resistance. npj Biofilms and Microbiomes, 11(1), Article 80. https://doi.org/10.1038/s41522-025-00694-x

Petersen, M. E., Khamas, A. B., Østergaard, L. J., Jørgensen, N. P. & Meyer, R. L. (2025). Combination therapy delays antimicrobial resistance after adaptive laboratory evolution of Staphylococcus aureus. Antimicrobial Agents and Chemotherapy, 69(4), Article e01483-24. https://doi.org/10.1128/aac.01483-24

Del Rey, Y. C., Rikvold, P. D., Lund, M. B., Raittio, E. J., Schramm, A., Meyer, R. L. & Schlafer, S. (2025). Arginine modulates the pH, microbial composition, and matrix architecture of biofilms from caries-active patients. International Journal of Oral Science, 17(1), Article 70. https://doi.org/10.1038/s41368-025-00404-5

Recent publications

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Rikvold, P. D., K. Johnsen, K., Del Rey, Y. C., Knap, I., Holz, C., Meyer, R. L., Jørgensen, M. R. & Schlafer, S. (2025). A randomized controlled trial on the effect of multiple-enzyme treatment on dental plaque formation. Caries Research, 59(4). https://doi.org/10.1159/000546564
Rikvold, P. D., K. Johnsen, K., Del Rey, Y. C., Knap, I., Holz, C., Meyer, R. L., Jørgensen, M. R. & Schlafer, S. (2025). A randomized controlled trial on the effect of multiple-enzyme treatment on dental plaque formation.
Rikvold, P., K. Johnsen, K., Chokyu Del Rey, Y., Knap, I., Holz, C., Meyer, R. L., Jørgensen, M. R. & Schlafer, S. (2025). A randomized controlled trial on the effect of multiple-enzyme treatment on dental plaque formation. Poster session presented at ORCA: 72nd Congress of the European Organization for Caries Research, Leeds, United Kingdom.
Rikvold, P., K. Johnsen, K., Chokyu Del Rey, Y., Knap, I., Holz, C., Meyer, R. L., Jørgensen, M. R. & Schlafer, S. (2025). A randomized controlled trial on the effect of multiple-enzyme treatment on the microbial plaque composition. Caries Research, 59, 321. https://doi.org/10.1159/000546564
Schlafer, S., K. Johnsen, K., Chokyu Del Rey, Y., Meyer, R. L., Skov Hansen, L. B., Knap, I., Holz, C., Jørgensen, M. R. & Rikvold, P. (2025). A randomized controlled trial on the effect of multiple-enzyme treatment on the microbial plaque composition. Poster session presented at ORCA: 72nd Congress of the European Organization for Caries Research, Leeds, United Kingdom.
Chokyu Del Rey, Y., Rikvold, P., Lund, M. B., Raittio, E., Schramm, A., Meyer, R. L. & Schlafer, S. (2025). Arginine mitigates pH drops and modulates the composition and architecture of biofilms from caries-active patients. Abstract from ORCA: 72nd Congress of the European Organization for Caries Research, Leeds, United Kingdom.
Chokyu Del Rey, Y., Rikvold, P., Lund, M. B., Raittio, E., Schramm, A., Meyer, R. L. & Schlafer, S. (2025). Arginine mitigates pH drops and modulates the composition and architecture of biofilms from caries-active patients. Poster session presented at ORCA: 72nd Congress of the European Organization for Caries Research, Leeds, United Kingdom.

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Collaborations with industry

Revised 04.02.2026
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Lise Refstrup Linnebjerg Pedersen