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Interdisciplinary Nanoscience Center

Biofilm group (Prof. Rikke Louise Meyer)

The group

My research combines microbiology and nanotechnology in pursuit of understanding how biofilms establish, and how they can be controlled.

Investigation of fundamental mechanisms in bacterial adhesion and biofilm formation, particularly the role of extracellular DNA.
Development of new approaches to control biofilms and treat biofilm infections through targeted drug delivery, novel antibiotics and nanobiotics, and non-biocidal biofilm control with e.g. enzymes or salinity oscillation.

2025 highligts

Ajunwa, O. M., Minero, G. A. S., Jensen, S. D. & Meyer, R. L. (2025). Hemin-binding DNA structures on the surface of bacteria promote extracellular electron transfer. Nucleic Acids Research, 53(15), Article gkaf790. https://doi.org/10.1093/nar/gkaf790

Dybtved, M. S., Petersen, M. E., Firdausy, A. F., Johansen, M. I., Faddy, E., Gadeberg, C., Østergaard, L., Jørgensen, N. P., Glud, L. N., Søgaard, A. B., Meyer, R. L. & Zelikin, A. N. (2025). Broad-Spectrum Antimicrobial Treatment Targeted Through Drug Conjugation to Vancomycin. Advanced Healthcare Materials, Article e03932. Advance online publication. https://doi.org/10.1002/adhm.202503932

Evans, D. C. S., Kristensen, M. F., Minero, G. A. S., Palmén, L. G., Knap, I., Tiwari, M. K., Schlafer, S. & Meyer, R. L. (2025). Dental biofilms contain DNase I-resistant Z-DNA and G-quadruplexes but alternative DNase overcomes this resistance. npj Biofilms and Microbiomes, 11(1), Article 80. https://doi.org/10.1038/s41522-025-00694-x

Petersen, M. E., Khamas, A. B., Østergaard, L. J., Jørgensen, N. P. & Meyer, R. L. (2025). Combination therapy delays antimicrobial resistance after adaptive laboratory evolution of Staphylococcus aureus. Antimicrobial Agents and Chemotherapy, 69(4), Article e01483-24. https://doi.org/10.1128/aac.01483-24

Del Rey, Y. C., Rikvold, P. D., Lund, M. B., Raittio, E. J., Schramm, A., Meyer, R. L. & Schlafer, S. (2025). Arginine modulates the pH, microbial composition, and matrix architecture of biofilms from caries-active patients. International Journal of Oral Science, 17(1), Article 70. https://doi.org/10.1038/s41368-025-00404-5

Recent publications

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Nielsen, J. L., Meyer, R. L., Xia, Y., Kong, Y. & Nielsen, P. H. (2008). Identification and characterization of the fermenting microbial community in enhanced biological phosphorus removal plants. Paper presented at International symposium for microbial ecology (ISME), Cairns, Australia, August 2008, Cairns, Australia.

Meyer, R. L., Iversen, A., Pillai, S., Bischoff, C. & Besenbacher, F. (2008). Nanofunctionalised sol-gel surface coatings for biofilm prevention. Paper presented at Nanotech Northern Europe, Copenhagen, Denmark.

Meyer, R. L., Allen, D. E. & Smith, S. (2008). Nitrification and denitrification as sources of sediment nitrous oxide production: A microsensor study. Marine Chemistry, 110(1-2), 68.

Mohanakrishnan, J., Gutierrez, O., Meyer, R. L. & Yuan, Z. (2008). Nitrite effectively inhibits sulfide and methane production in a laboratory scale sewer reactor. Water Research, 42(14), 3961-3971.

Pillai, S., Arpanaei, A., Meyer, R. L., Besenbacher, F. & Kingshott, P. (2008). Preventing fibrinogen and HSA adsorption by coating surfaces with aqueous extracts of fish proteins.. Paper presented at 8^th World Biomaterials Congress, Amsterdam, Netherlands.

Pillai, S., Singh, G., Mukhopadhyay, R., Hemmersan, A. G., Meyer, R. L., Besenbacher, F. & Kingshott, P. (2008). Self-assembled binary polymeric colloid patterns on hydrophobic surfaces. Paper presented at Danish Colloid and Interface Society Annual Meeting, Aarhus, Denmark.

Kingshott, P., Pillai, S., Singh, G., Meyer, R. L., Blomfeld, C., Roberts, A. & Besenbacher, F. (2008). Surface Characterization of Ordered Nanopatterns made from Self-Assembly of Mixed Nanoparticles. Paper presented at AVS 54th International Symposium and Exhibition, Seattle, United States.

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Collaborations with industry

Revised 04.02.2026

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Lise Refstrup Linnebjerg Pedersen