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Protein Biophysics (Prof. Daniel Otzen)

Daniel Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset

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Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  

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News

iNANO PhD Student Hanna Leemreize Wins Poster Award

- Talent development

PhD student Hanna Leemreize of the group of Henrik Birkedal has won a poster award at the Euro Bio-Inspired 2014 conference which was held 18-21 March…

iNANO researcher receives award for excellent international collaboration from the Strategic Research Council.

- Talent development

Dorthe B. Ravnsbæk receives the Strategic Research Council’s award for excellent international research corporation. The award is given to Dorthe on…

iNANO Post Doc receives innovation award from the Strategic Research Counsil

- Awards

Post.doc Dang Quang Svend Le, from Jørgen Kjems’ research group, has been selected winner in the category strategic research with a particularly great innovation potential.

Recent publications

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