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Protein Biophysics (Prof. Daniel Otzen)

Daniel Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset


Group members
Research funding

Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  

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The world is drowning in plastic: New centre can become one of the planet's lifebuoys

Professor Daniel Otzen, Interdisciplinary Nanoscience Center (iNANO), Aarhus University

The world's oceans are filling with plastic, and the global community cannot keep up with production and break down the large amount of plastic produced every year. We must find a solution, says Professor Daniel Otzen (iNANO). With DKK 57 million from the Novo Nordisk Foundation’s Challenge Programme, he can now open a centre for plastic research at Aarhus University.

New centre director at iNANO

Professor Thomas Vosegaard appointed new center director at iNANO. (Photo: MJ, AU Photo)

On 27 January 2022, the position of center director at iNANO was advertised and could be applied for until 9 March. Acting center director Thomas Vosegaard applied for the position and is appointed new center director as of 1 June, 2022. Congratulations to center director Thomas Vosegaard!

Recent publications

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