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Protein Biophysics (Prof. Daniel Otzen)

Daniel Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset

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Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  

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News

Villum Synergy grants for data-driven projects at Aarhus University

Niels Christian Nielsen and Henrik Birkedal each receive a Villum Synergy grant for data-driven projects. (Photos: Lars Kruse and Lise Balsby, respectively)

Prof. Niels Christian Nielsen and Prof. Henrik Birkedal from Department of Chemistry and iNANO each receive a Villum Synergy grant for their data-driven interdisciplinary research projects. Their research projects are based on data science within optimizing sensitivity in Nuclear Magnetic Resonance (NMR) spectroscopy and improving the analysis of 3D imaging data, respectively.

Jan Skov Pedersen receives honorary doctorate from the University of Oslo

Professor Jan Skov Pedersen. Photo: AU

Professor Jan Skov Pedersen receives an honorary doctorate at the Faculty of Mathematics and Natural Sciences at the University of Oslo. The honorary title will be awarded at the university’s annual celebration.

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