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Protein Biophysics (Prof. Daniel Otzen)

Daniel Erik Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset


Group members
Research funding

Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  

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Unveiling the Protective Power of Extracellular DNA Structures in Bacterial Biofilms

A team of researchers led by Professor Rikke Louise Meyer sheds light on how non-canonical DNA structures safeguard bacterial biofilms. Illustr.: Gabriel Antonio Salvador Minero

A collaborative effort between iNANO researchers and Aarhus University Hospital illuminates the mysteries of bacterial biofilms, discovering how…

Cryo-microscopy reveals nano-sized copy machine implicated in origin of life

The picture shows an RNA polymerase ribozyme thought to be implicated in the origin of life. The ribozyme is shown frozen in ice to symbolize how it was frozen in time for imaging and how it works best under ice-cold conditions. The active site is highlighted by a yellow/red light and the proposed position of the template-product helix is shown in transparent. Image credit: Rune Kidmose.

RNA is thought to have sparked the origin of life by self-copying. Researchers from Aarhus University, Denmark, and MRC LMB Cambridge, England, have…

Recent publications

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