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Protein Biophysics (Prof. Daniel Otzen)

Daniel Erik Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset


Group members
Research funding

Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  

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Researchers from iNANO and Department of Chemistry receive grants for Green Breakthrough

Researchers from iNANO and Department of Chemistry receive grants for Green Breakthrough grants. Image: Independent Research Fund Denmark

Independent Research Fund Denmark supports four research projects with researchers from iNANO and Department of Chemistry at the helm. From…

New research facilities will help us understand the chemical properties of surfaces

Accurate understanding of the chemistry of surfaces is crucial for many existing and new technologies within life- and materials science, among…

Recent publications

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