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Protein Biophysics (Prof. Daniel Otzen)

Daniel Erik Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset


Group members
Research funding

Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  

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New research facilities will help us understand the chemical properties of surfaces

Accurate understanding of the chemistry of surfaces is crucial for many existing and new technologies within life- and materials science, among…

Triple DNA helix artwork featured on the cover of prestigious journal

Cover for Advanced Materials on Triplex Origami (Adv. Mater. 40/2023, 2302497).

In a beautiful fusion of science and art, two PhD students from iNANO at Aarhus University have created a stunning piece of folded paper art that now…

Recent publications

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