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Bioengineered solutions to improve cancer immunotherapies. Mandrup, O.A., and Howard, K.A. Ther Deliv. 2021, 12, 339-341.https://doi.org/10.4155/tde-2021-0019


Programmable half-life and anti-tumour effects of bispecific T-cell engager-albumin fusions with tuned FcRn affinity. Mandrup, O.A., Ong, S.C., Lykkemark, S., Dinesen, A., Rudnik-Jansen, I., Dagnaes-Hansen, N.F., Andersen, J.T., Alvarez-Vallina, L., and Howard, K.A. Commun Biol. 2021, 4, 310. https://doi.org/10.1038/s42003-021-01790-2


A Reagent for Amine-Directed Conjugation to IgG1 Antibodies. Marcher, A., Palmfeldt, J., Nisavic, M., and Gothelf, K.V. Angew Chem Int Ed Engl. 2021, 60, 6539-6544. https://doi.org/10.1002/anie.202013911


Roadmap on nanomedicine. Decuzzi, P., Peer, D., Mascolo, D.D., Palange, A.L., Manghnani, P.N., Moghimi, S.M., Farhangrazi, Z.S., Howard, K.A., Rosenblum, D., Liang, T., et al. Nanotechnology. 2021, 32, 012001. https://doi.org/10.1088/1361-6528/abaadb


Avoiding the Pitfalls of siRNA Delivery to the Retinal Pigment Epithelium with Physiologically Relevant Cell Models. Ramsay, E., Ravina, M., Sarkhel, S., Hehir, S., Cameron, N.R., Ilmarinen, T., Skottman, H., Kjems, J., Urtti, A., Ruponen, M., et al. Pharmaceutics. 2020, 12.ARTN 667, https://doi.org/10.3390/pharmaceutics12070667

24) Improved Cancer Targeting by Multimerizing Aptamers on Nanoscaffolds. Omer, M., Andersen, V.L., Nielsen, J.S., Wengel, J., and Kjems, J. Mol Ther-Nucl Acids. 2020, 22, 994-1003. https://doi.org/10.1016/j.omtn.2020.10.013
23) LifeTime and improving European healthcare through cell-based interceptive medicine. Rajewsky, N., Almouzni, G., Gorski, S.A., Aerts, S., Amit, I., Bertero, M.G., Bock, C., Bredenoord, A.L., Cavalli, G., Chiocca, S., et al. Nature. 2020, 587, 377-386. https://doi.org/10.1038/s41586-020-2715-9

Albumin-based drug designs for pharmacokinetic modulation. Pilati, D., and Howard, K.A. Expert Opin Drug Met. 2020, 16, 783-795. https://doi.org/10.1080/17425255.2020.1801633


FcRn overexpression in human cancer drives albumin recycling and cell growth; a mechanistic basis for exploitation in targeted albumin-drug designs. Larsen, M.T., Mandrup, O.A., Schelde, K.K., Luo, Y., Sorensen, K.D., Dagnaes-Hansen, F., Cameron, J., Stougaard, M., Steiniche, T., and Howard, K.A. J Control Release. 2020, 322, 53-63. https://doi.org/10.1016/j.jconrel.2020.03.004


Albumin-Binding Fatty Acid-Modified Gapmer Antisense Oligonucleotides for Modulation of Pharmacokinetics. Cai, Y., Lou, C., Wengel, J., and Howard, K.A. Methods Mol Biol. 2020, 2176, 163-174. https://doi.org/10.1007/978-1-0716-0771-8_12


Introduction of an Aldehyde Handle on Nanobodies by Affinity-Guided Labeling. Mortensen, M.R., Skovsgaard, M.B., Marcher, A., Andersen, V.L., Palmfeldt, J., Nielsen, T.B., Torring, T., Laursen, N.S., Andersen, K.R., Kjems, J., et al. Bioconjugate Chem. 2020, 31, 1295-1300. https://doi.org/10.1021/acs.bioconjchem.0c00151


Two-Dimensional Coordination Networks from Cyclic Dipeptides. Guo, Y., Nuermaimaiti, A., Kjeldsen, N.D., Gothelf, K.V., and Linderoth, T.R. J Am Chem Soc. 2020, 142, 19814-19818. https://doi.org/10.1021/jacs.0c08700


Disulphide-mediated site-directed modification of proteins. Nielsen, T., Marcher, A., Drobnakova, Z., Hucko, M., Stengl, M., Balsanek, V., Wiberg, C., Nielsen, P.F., Nielsen, T.E., Gothelf, K.V., et al. Org Biomol Chem.2020, 18, 4717-4722. https://doi.org/10.1039/d0ob00861c


A new class of recombinant human albumin with multiple surface thiols exhibits stable conjugation and enhanced FcRn binding and blood circulation Schelde, K. K.; Nicholls, K.; Dagnæs-Hansen, F.; Rawsthorne, H.; Andersen, B.; Finnis, C. J. A.; Williamson, M.; Cameron, J.; Howard, K. A. J Biol. Chem. 2019, 294, 3735-3743. https://doi.org/10.1074/jbc.RA118.005870


Optimised approach to albumin–drug conjugates using monobromomaleimide-C-2 linkers Wall, A.; Nicholls, K.; Caspersen, M. B.; Skrivergaard, S.; Howard, K. A.; Karu, K.; Chudasama, V.; Baker, J. R. Org. Biomol. Chem. 2019, 17, 7870-7873, https://doi.org/10.1039/C9OB00721K


Fibrin-hyaluronic acid hydrogel-based delivery of antisense oligonucleotides for ADAMTS5 inhibition in co-delivered and resident joint cells in osteoarthritis Garcia, J. P.;  Stein, J.; Cai, Y.; Riemers, F.; Wexselblatt, E.; Wengel, J. Tryfonidous, M.; Yayon, A.; Howard, K. A.; Creemers, L. B., J. Contol Release, 2019, 294, 247-258, https://doi.org/10.1016/j.jconrel.2018.12.030


Cellular uptake of covalent and non-covalent DNA nanostructures with different sizes and geometries Raniolo, S.; Croce, S.; Thomsen, R. P.; Okholm, A. H.; Unida, V.; Iacovelli, F.; Manetto, A.; Kjems, J.; Desideri, A.; Biocca, S., Nanoscale, 2019, 11, 10808-10818,  https://doi.org/10.1039/C9NR02006C


An RNA Origami Octahedron with Intrinsic siRNAs for Potent Gene Knockdown Høiberg, H.C.; Sparvath, S. M.; Andersen, V. L.; Kjems, J.; Andersen, E. S., Biotechnol J. 2019, 14, e1700634, https://doi.org/doi:10.1002/biot.201700634


Genetically-encoded, functional single-strand RNA origami Krissanaprasit, A.; Key, C.; Fergione, M..; Froehlich, K.; Pontula, S.; Hart, M.; Carriel, P.; Kjems, J.; Andersen, E. S.; LaBean, T. H. Anticoagulant Adv. Mat,. 2019, 31, e1808262, https://doi:10.1002/adma.201808262


Toehold-Mediated Strand Displacement in a Triplex Forming Nucleic Acid Clamp for Reversible Regulation of Polymerase Activity and Protein Expression Nguyen, T. J. D.; Manuguerra, I.; Kumar, V.; Gothelf, K. V. Chemistry 2019, 25, 12303-12307, https://doi.org/10.1002/chem.201903496


Aptamer-Directed Conjugation of DNA to Therapeutic Antibodies Skovsgaard, M. B.; Mortensen, M. R.; Palmfeldt, J.; Gothelf, K. V. Bioconjugate Chem 2019, 30, 2127-2135. https://doi.org/10.1021/acs.bioconjchem.9b00363


Nucleic Acids as a Nature-Inspired Scaffold for Macromolecular Prodrugs of Nucleoside Analogues Krüger, F.; Kumar, V.; Monge, P.; Conzelmann, C.; Smith, N.; Gothelf, K. V.; Tolstrup, M.; Münch, J.; Zelikin, A. N. Adv. Sci. 2019, 6, 1802095. https://doi.org/10.1002/advs.201802095


Selective delivery of doxorubicin to EGFR+ cancer cells by Cetuximab‐DNA conjugates Liu, T.; Song, P.; Märcher, A.; Kjems, J.; Yang, C.; Gothelf, K. V. ChemBioChem, 2019, 20. 1014-1018. https://doi.org/10.1002/cbic.201800685


A Self-Assembled, Modular Nucleic Acid-Based Nanoscaffold for multivalent Theranostic Medicine Andersen, V. L.; Vinther, M.; Kumar, R.; Ries, A.; Wengel, J.; Nielsen, J. S.; Kjems, J. Theranostics 2019, 9, 2662-2677 https://doi.org/10.7150/thno.32060


Peptide-Directed DNA-Templated Protein Labelling for The Assembly of a Pseudo-IgM Nielsen, T. B.; Thomsen, R. P.; Mortensen, M. R.; Kjems, J.; Nielsen, P. F.; Nielsen, T. E.; Kodal, A. L. B.; Clo, E.; Gothelf, K. V. Angew. Chem. 2019https://doi.org/10.1002/anie.201903134


Considerations on probe design for affinity guided protein conjugation Mortensen, M. R.; Skovsgaard, M. B.; Gothelf, K. V. ChemBioChem 2019https://doi.org/10.1002/cbic.201900157


Affinity-Guided Conjugation to Antibodies for use in Positron Emission Tomography Skovsgaard, M. B.; Jeppesen, T. E.; Mortensen, M. R.; Nielsen, C. H.; Madsen, J.; Kjær, A.; Gothelf, K. V. Bioconjugate Chem.2019, 30, 881-887, https://doi.org/10.1021/acs.bioconjchem.9b00013


Chemistries for DNA Nanotechnology Madsen, M; Gothelf, K.V. Chem. Rev. 2019https://doi.org/10.1021/acs.chemrev.8b00570


Imidazole Carbamate Probes for Affinity Guided Azide-Transfer to Metal-Binding Protein Mortensen, M. R.; Nielsen, N. L.; Palmfeldt, J.; Gothelf K. V. Org. Biomo.l Chem.201917, 1379-1383,https://doi.org/10.1039/c8ob03017k