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Protein Biophysics (Prof. Daniel Otzen)

Daniel Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset

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Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  

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News

Victoria Birkedal to host meeting at the first day of the Biophysical Society annual meeting

- People

The meeting on Nanoscale biophysics is to be held Saturday, February 15, 2014
San Francisco, California.

Find the program here.

PROFESSOR KURT GOTHELF RECEIVES GRANT FROM THE LUNDBECK FOUNDATION

- Awards

Professor Kurt Gothelf receives a Lundbeck grant of DKK 1 million for research in Oligonucleotide-regulated activity of protein toxins and drugs

TWO INANO SCIENTISTS HANDED THEIR AWARDS AT ELITE RESEARCHER CEREMONY

- People

At a ceremony on 6 February, in the beautiful Ny Carlsberg Glyptotek, Prof. Daniel Otzen officially received the EliteForsk (Elite researcher) award…

Recent publications

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