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Protein Biophysics (Prof. Daniel Otzen)

Daniel Erik Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset

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Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  

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News

Opening of new large-scale NMR equipment

- Research News

The Danish Center for Ultrahigh-Field NMR Spectroscopy was inaugurated on June 3.

Lundbeck Grant to Henrik Birkedal

- Awards

Associate Professor Henrik Birkedal, iNANO & Department of Chemistry, has received a grant from the Lundbeck Foundation in the sum of DKK 1.575.000…

New CO2 Fixation Work Published in Angew. Chem. Int. Ed.

- Research News

Researchers at the Carbon Dioxide Activation Center (CADIAC), which is located at iNANO and the Department of Chemistry have recently published in…

Recent publications

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