Specific competencies

• P-type ATPases (Na/K-ATPase, Ca-ATPase, Zn-ATPase)
• Complement proteins: C3, C3a, C3b, C3d, C4, C4b, C5, C5a, CR3/CD11bCD18.
• Receptor for Advanced Glycation Endproducts (RAGE)
• Fab fragments of antibodies, free or in complex with antigen
• Sortilin receptors
• Ribosomes
• Elongation factor Tu / Elongation factor Ts
• Sortilin
• GGA-VHS domain
• T. thermophilus NlpC/P60 

Industrial Collaborations

• Noxxon Pharma AG, Berlin. Structure determination of the complex between complement C5a and a therapeutic L-RNA aptamer
• Lundbeck (non-disclosed)
• Priaxon AG (non-disclosed)
• GSK (non-disclosed)
• Ono Pharmaceuticals
• Dupont (non-disclosed)

Available methods

The macromolecular X-ray lab is equipped with a Rigaku Compact Homelab Pilatus system consisting of MicroMax-003 generator with confocal Max-Flux optics, the AFC11 partial Chi diffractometer and Pilatus 200K area detector. The system is equipped with an Oxford Cryostream 700 that allows experiments to be carried out at 100K. In situ x-ray screening of crystallization experiments is also possible.

For crystallization we have a range of methods available such Lipidic Cubic Phase with Art Robbins instrument (ARI) LCP Gryphon and vapor diffusion crystallization from hand setup to Nano drop crystallization with Oryx or Mosquito crystallization robots.

Contact

For more information about the initial tests, projects, and collaborations please contact:

Claus Olesen
Department of Molecular Biology and Genetics
Aarhus University
6126 0035 or ceo@mbg.au.dk