Protein Biophysics (Prof. Daniel Otzen)

Daniel Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset
M
H 1592, 224
P +4587156741
P +4520725238
Group members
Research funding

Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  

News

Morten Foss collaborates with Elos Medtech on Grand Solution project funded by Innovation Fund Denmark. (Photo: Lars Kruse, AU Photo)

2019.02.08 | iNano

Intersectoral project on eliminating the unwanted metallic shine of dental implants

Senior scientist Morten Foss (iNANO) collaborates with Elos Medtech and Technical University of Denmark (DTU) on developing dental titanium implants with aesthetic white surfaces. Innovation Fund Denmark invests in the dental surface project with the Grand Solutions programme.

Professor Troels Skrydstrup receives Semper Ardens grant from the Carlsberg Foundation for improving plastics recycling. (Photo: Lars Kruse, AU Photo)

2019.02.01 | iNano

Funding for research in improving plastics recycling

Over one third of the plastics produced are used only once and then discarded. The majority of these plastics end up in landfills and our oceans. Professor Troels Skrydstrup has been awarded a Semper Ardens grant for developing new means to deconstruct some of the most commonly used plastics, which can then be exploited again as new useful plastic.

Professor Birgit Schiøtt receives DKK 6.6 million for digital infrastructure platform. (Photo: Lars Kruse)

2019.01.31 | iNano

DKK 6.6 m for biomolecular simulations

Professor Birgit Schiøtt (Department of Chemistry and iNANO) has received DKK 6.6 million (EUR 0.9 million) to establish a digital infrastructure platform to make simulations of complex biological systems.

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