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Protein Biophysics (Prof. Daniel Otzen)

Daniel Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset
M
H 1592, 224
P +4587156741
P +4520725238
Group members
Research funding

Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  

News

Flemming Besenbacher, iNANO founder and Professor, appointed head of new think tank on the prevention of food waste and loss. (Photo by Roar Lava Paaske)

2019.04.10 | iNano

Professor Flemming Besenbacher head of new think tank on the prevention of food waste and food loss

Flemming Besenbacher, iNANO founder and Professor, will lead a new think tank, which will make Denmark a pilot country in relation to the UN Sustainable Development Goal on food waste and loss.

Assoc. Prof. Henrik Birkedal (Department of Chemistry and iNANO) is featured by DR (Danish Broadcasting Corporation) in relation to his research in bio-inspired materials. (Photo: Lise Balsby)

2019.04.08 | iNano

Learning more about nature's chemical solutions

Assoc. Prof. Henrik Birkedal (Department of Chemistry and iNANO) is featured by DR (Danish Broadcasting Corporation) in relation to his research in bio-inspired materials. The interview follows recent studies by researchers at Texas A&M University on how a shrimp claw inspires new method of underwater plasma generation. (Article in Danish only)

AU researchers Jakob T. NIelsen and Frans Mulder present benchmark for testing protein disorder prediction programmes. NMR ensemble structure for the core domain of the protein p53 colored according to CheZOD Z-scores. (Image: Jakob Toudahl and Frans Mulder in Scientific Reports)

2019.04.05 | iNano

How good are protein disorder prediction programmes actually?

Until now it was difficult to answer this question, as a good benchmark for testing these bioinformatics programmes was lacking. AU scientists, Dr. Jakob T. Nielsen and Dr. Frans A.A. Mulder present an analysis in Scientific Reports using a comprehensive compilation of experimental data from NMR spectroscopy.

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