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Protein Biophysics (Prof. Daniel Otzen)

Daniel Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset
Group members
Research funding

Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  

News

12 iNANO affiliated researchers receive DKK 44 million from Independent Research Fund Denmark for research within drug targeting, magnetogenetics, improved batteries for storage of energy from renewable energy sources, improved immunotherapy, strong reversible adhesives, improved solar cells, studies in the complicated interactions between DNA and proteins, and much much more. Photos by Lars Kruse, Maria Randima and Jesper Rais.

2019.05.10 | iNano

44 million for original research ideas and initiatives by iNANO affiliated researchers

Independent Research Fund Denmark has granted DKK 44 million in total for 12 iNANO affiliated researchers. This funding will support research within drug targeting, magnetogenetics, improved batteries for storage of energy from renewable energy sources, improved immunotherapy, strong reversible adhesives, improved solar cells, studies in the…

Chairman of the price committee Niels Chr. Nielsen has handed over the Danish polymer price - ATV | Elastyrenprisen, DKK 100,000, for Associate Professor Henrik Birkedal, INANO and Department of Chemistry at Aarhus University. Photo: Tom Jersø

2019.05.10 | iNano

Assoc. Prof. Henrik Birkedal honored by the Danish Academy of Technical Sciences

Congratulations to Associate Professor Henrik Birkedal who is awarded the Danish polymer prize, Elastyrenprisen 2019, for being internationally recognized and leading within his research in self-healing polymer gels. The award is given by the Danish Academy of Technical Sciences (ATV).

Collaboration between Novo Nordisk and Professor Kurt Gothelf’s laboratory at Aarhus University yields novel method to engineer large multi-antibody-like nanostructures using DNA nanotechnology. Assembly of an artificial IgM from a DNA-antibody conjugate and a small 5-way DNA structure. The structure is characterized by Transmission Electron Microscopy (100 x 100 nm). Graphics by Thorbjørn B. Nielsen and Kurt Gothelf with permission from Angewandte Chemie Int. Ed.

2019.05.10 | iNano

New efficient way to engineer nanostructures mimicking natural immune response complexes

Collaboration between Novo Nordisk and Professor Kurt Gothelf’s laboratory at Aarhus University yields novel method to engineer large multi-antibody-like nanostructures using DNA nanotechnology. The results demonstrate the potential for assembly of multiple proteins and also other materials to enhance properties of traditional therapies.

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