Protein Biophysics (Prof. Daniel Otzen)

Daniel Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset
M
H 1592, 224
P +4587156741
P +4520725238
Group members
Research funding

Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  

News

Professor Gregers Rom Andersen (left), Cryo-EM Facility Manager Thomas Boesen and Professor Poul Nissen in front of the Titan-Krios flagship microscope at Aarhus University (photo: Lisbeth Heilesen).

2018.11.08 | Research News

DKK 30 million for high-tech electron microscopes for research in molecular cell biology

The Minister for Higher Education and Science has approved funding for three new research infrastructures, of which DKK 30.76 million goes to EMBION – a research infrastructure for cryo-electron microscopy (cryo-EM) on biological materials.

2018.11.01 | iNano

New insight into the mechanism of the drug against sclerosis and psoriasis

Professor Poul Nissen and his research team with contributions from e.g. Kurt Gothelf's laboratories have provided fundamental new insight into the mechanism of the medical drug dimethyl fumarate, which is the active component of important treatments for multiple sclerosis and psoriasis. The results contribute to the development of new strategies…

3D print of the Sodium Potassium Pump at the exhibition ‘Profession and Passion – a Life in Science’ at Steno Museum, Aarhus University. iNANO researchers, Ebbe Sloth Andersen, Mette Jepsen and Poul Nissen contribute to the exhibition. Photo: Ida Marie Jensen (AU Photo)

2018.10.12 | iNano

iNANO researchers contribute to exhibition at Steno Museum

The exhibition ‘Profession and Passion – a Life in Science’ is launched at the Steno Museum, Aarhus University. iNANO researchers have contributed to the exhibition on what impels researchers and how science and passion live alongside each other.

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