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Protein Biophysics (Prof. Daniel Otzen)

Daniel Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset
Group members
Research funding

Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  

News

Flemming Besenbacher receives the title of Commander of the order of Dannebrog. (Private photo by courtesy of Flemming Besenbacher)

2019.01.08 | iNano

Professor Flemming Besenbacher receives royal honor

On November 2, 2018, Professor Flemming Besenbacher received the title of Commander of the Order of Dannebrog.

Mogens Christensen gives his views in Aktuel Naturvidenskab on the transition from using fossil fuels to green energy. (Photo: Maria Randima)

2019.01.04 | iNano

Do we have the necessary raw materials for a green transition?

Associate Professor Mogens Christensen is giving his views on the process of transition from using fossil fuels to green energy in Aktuelt Naturvidenskab.

Troels Skrydstrups research into transition metal catalysts as chemical tools of the future is reported on by Aktuel Naturvidenskab. (Photo: Lars Kruse, AU Photo)
Article in Aktuel Naturvidenskab on Troels Skrydstrups research into transition metal catalysts (Article by Kristian Sjøgren, Photo: Colourbox)

2019.01.04 | iNano

Catalysts - creating chemical tools of the future

Read in Aktuel Naturvidenskab about Skrydstrup Group's work on transition metal catalysts as tools for many industries in their need to make better products for a world with growing pains.

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