Dong, MD, Howard, KA, Oupicky, D, Bisht, H
, Kjems, J & Besenbacher, F 2007, '
Visualization of thermally activated nanocarriers using in situ atomic force microscopy: Nanotechnology',
Nanotechnology, vol. 18, no. 18, 185501.
https://doi.org/10.1088/0957-4484/18/18/185501
Li, YY, Femenias, MR, Aslan, HH, Yu, YY
, Howard, K, Dong, MD, Besenbacher, FF & Chen, MM 2014, '
Ultraporous interweaving electrospun microfibers from PCL-PEO binary blends and their inflammatory responses',
Nanoscale, vol. 6, no. 6, pp. 3392-3402.
https://doi.org/10.1039/c3nr06197c
Ebbesen, MF, Olesen, MTJ, Gjelstrup, MC, Pakula, MM, Larsen, EK, Hansen, IM, Hansen, PL, Mollenhauer, J, Malle, BM
& Howard, K 2015, '
Tunable CD44-Specific Cellular Retargeting with Hyaluronic Acid Nanoshells',
Pharmaceutical Research, vol. 32, no. 4, pp. 1462-1474.
https://doi.org/10.1007/s11095-014-1552-7
Whitehead, BJ, Wu, L
, Hvam, ML, Aslan, H, Dong, M, Dyrskjøt, L, Ostenfeld, MS, Moein Moghimi, S
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Tumour exosomes display different differential mechanical and complement activation properties dependent on malignant state: implications in endothelial leakiness',
Journal of Extracellular Vesicles, vol. 4, 29685.
https://doi.org/10.3402/jev.v4.29685
Hangiu, O, Compte, M
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, Mandrup, OA, Erce-Llamazares, A, Lázaro-Gorines, R, Nehme-Álvarez, D, Domínguez-Alonso, C
, Harwood, SL, Alfonso, C, Blanco, B, Rubio-Pérez, L, Jiménez-Reinoso, A, Díez-Alonso, L, Blanco, FJ, Sanz, L
, Howard, KA & Álvarez-Vallina, L 2022, '
Tumor targeted 4-1BB agonist antibody-albumin fusions with high affinity to FcRn induce anti-tumor immunity without toxicity',
iScience, vol. 25, no. 9, 104958.
https://doi.org/10.1016/j.isci.2022.104958Kjems, J, Overgaard, J, Howard, K, Alsner, J, Besenbacher, F & Nawroth, I,
Treatment of radiation-induced fibrosis, Patent No. WO2010085959A1.
Christiansen, SH, Zhang, X, Juul-Madsen, K, Hvam, ML, Vad, BS, Behrens, MA, Thygesen, IL, Jalilian, B, Pedersen, JS, Howard, K, Otzen, DE & Vorup-Jensen, T 2017, '
The random co-polymer glatiramer acetate rapidly kills primary human leukocytes through sialic-acid-dependent cell membrane damage',
Biochimica et biophysica acta - Biomembranes, vol. 1859, no. 3, pp. 425-437.
https://doi.org/10.1016/j.bbamem.2017.01.001
Liu, X, Howard, KA, Dong, M, Andersen, MØ, Rahbek, UL, Johnsen, MG, Hansen, OC
, Besenbacher, F & Kjems, J 2007, '
The influence of polymeric properties on chitosan/siRNA nanoparticle formulation and gene silencing',
Biomaterials, vol. 28, no. 6, pp. 1280-8.
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Christiansen, SH, Murphy, RA
, Juul-Madsen, K, Fredborg, M, Hvam, ML, Axelgaard, E, Skovdal, SM, Meyer, RL, Sorensen, UBS, Moeller, A, Nyengaard, JR, Norskov-Lauritsen, N, Wang, M, Gadjeva, M
, Howard, KA, Davies, JC
, Petersen, E & Vorup-Jensen, T 2017, '
The Immunomodulatory Drug Glatiramer Acetate is Also an Effective Antimicrobial Agent that Kills Gram-negative Bacteria',
Scientific Reports, vol. 7, no. 1, 15653.
https://doi.org/10.1038/s41598-017-15969-3
Gao, S, Dagnæs-Hansen, F, Nielsen, EJB, Wengel, J
, Besenbacher, F, Howard, KA & Kjems, J 2009, '
The effect of chemical modification and nanoparticle formulation on stability and biodistribution of siRNA in mice',
Molecular Therapy, vol. 17, no. 7, pp. 1225-1233.
https://doi.org/10.1038/mt.2009.91
Whitehead, BJ, Hvam, ML, Bienk, K, Ostenfeld, MS & Howard, K 2014, '
The Application of a Fluorescent Pre-Labelling Method for Evaluation of Exosome Biodistribution', The 41st Annual Meeting & Exposition of the Controlled Release Society, Chicago, United States,
13/07/2014 -
16/07/2014.
Symons, RA, Colella, F, Collins, FL, Rafipay, AJ, Kania, K, McClure, JJ, White, N, Cunningham, I, Ashraf, S, Hay, E, Mackenzie, KS
, Howard, KA, Riemen, AHK, Manzo, A, Clark, SM, Roelofs, AJ & De Bari, C 2022, '
Targeting the IL-6-Yap-Snail signalling axis in synovial fibroblasts ameliorates inflammatory arthritis',
Annals of the Rheumatic Diseases, vol. 81, no. 2, pp. 214-224.
https://doi.org/10.1136/annrheumdis-2021-220875Ebbesen, MF, Schaffert, DH, Crowley, ML, Oupický, D
& Howard, K 2013, '
Synthesis of click-reactive HPMA copolymers using RAFT polymerization for drug delivery applications',
Journal of Polymer Science. Part A, Polymer Chemistry, vol. 51, no. 23, pp. 5091-5099.
https://doi.org/10.1002/pola.26941
Andersen, MØ, Nygaard, JV, Howard, K, Bak, RO, Paludan, SR, Raarup, MK, Besenbacher, F & Kjems, J 2007, '
Surface delivery of siRNA for implants',
European Cells & Materials, vol. 14, no. 3, pp. 118.
Ebbesen, MF, Whitehead, BJ, Gonzalez, BB, Kingshott, P
& Howard, K 2013, '
Surface analysis of PEGylated nano-shields on nanoparticles installed by hydrophobic anchors',
Pharmaceutical Research, vol. 30, no. 7, pp. 1758-1767.
https://doi.org/10.1007/s11095-013-1018-3
Miclaus, T, Bochenkov, V, Ogaki, R, Howard, K & Sutherland, DS 2014, '
Spatial Mapping and Quantification of Soft and Hard Protein Coronas at Silver Nanocubes',
Nano Letters, vol. 14, no. 4, pp. 2086-2093.
https://doi.org/10.1021/nl500277c
Juul-Madsen, K, Qvist, P, Bendtsen, KL, Langkilde, AE, Vestergaard, B
, Howard, K, Dehesa-Etxebeste, M
, Paludan, SR, Andersen, GR, Jensen, PH, Otzen, DE, Romero-Ramos, M & Vorup-Jensen, T 2020, '
Size-Selective Phagocytic Clearance of Fibrillar α-Synuclein through Conformational Activation of Complement Receptor 4',
Journal of Immunology, vol. 204, no. 5, pp. 1345-1361.
https://doi.org/10.4049/jimmunol.1900494
Larsen, EKU, Nielsen, T, Wittenborn, T, Birkedal, H, Vorup-Jensen, T, Jakobsen, MH
, Østergaard, L, Horsman, MR, Besenbacher, F, Howard, KA & Kjems, J 2009, '
Size-Dependent Accumulation of PEGylated Silane-Coated Magnetic Iron Oxide Nanoparticles in Murine Tumors',
A C S Nano, vol. 3, no. 7, pp. 1947-51.
https://doi.org/10.1021/nn900330m
Schmøkel, J, Voldum, A, Tsakiridou, G, Kuhlmann, M, Cameron, J
, Sørensen, ES, Wengel, J
& Howard, K 2017, '
Site-selective conjugation of an anticoagulant aptamer to recombinant albumins and maintenance of neonatal Fc receptor binding',
Nanotechnology, vol. 28, no. 20, 204004 .
https://doi.org/10.1088/1361-6528/aa6a9b
Andersen, MØ, Nygaard, JV, Burns, JS
, Raarup, MK, Nyengaard, JR, Bünger, C, Besenbacher, F, Howard, KA, Kassem, M & Kjems, J 2010, '
siRNA nanoparticle functionalization of nanostructured scaffolds enables controlled multilineage differentiation of stem cells',
Molecular Therapy, vol. 18, no. 11, pp. 2018-2027.
https://doi.org/10.1038/mt.2010.166
Decuzzi, P, Peer, D, Di Mascolo, D, Palange, AL, Manghnani, PN, Moein Moghimi, S, Shadi Farhangrazi, Z
, Howard, KA, Rosenblum, D, Liang, T, Chen, Z, Wang, Z, Zhu, JJ, Gu, Z, Korin, N, Letourneur, D, Chauvierre, C, van der Meel, R, Kiessling, F & Lammers, T 2021, '
Roadmap on nanomedicine',
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https://doi.org/10.1088/1361-6528/abaadbHoward, KA, Rahbek, UL, Liu, X, Damgaard, CK, Glud, SZ, Andersen, MØ, Hovgaard, MB, Schmitz, A, Nyengaard, JR, Besenbacher, F & Kjems, J 2006, '
RNA interference in Vitro and in Vivo using a novel chitosan/siRNA nanoparticle system',
Molecular Therapy, vol. 14, no. 4, pp. 476-484.
https://doi.org/10.1016/j.ymthe.2006.04.010
Kania, K, Colella, F, Riemen, AHK, Wang, H
, Howard, K, Aigner, T, Dell’Accio, F, Capellini, TD, Roelofs, AJ & De Bari, C 2020, '
Regulation of Gdf5 expression in joint remodelling, repair and osteoarthritis',
Scientific Reports, vol. 10, no. 1, 157, pp. 157.
https://doi.org/10.1038/s41598-019-57011-8Jeppesen, DK, Nawrocki, A
, Jensen, SG, Thorsen, K, Whitehead, B, Howard, K, Andersen, LD, Orntoft, TF, Larsen, MR
& Ostenfeld, MS 2014, '
Quantitative proteomics of fractionated membrane and lumen exosome proteins from isogenic metastatic and nonmetastatic bladder cancer cells reveal differential expression of EMT factors',
Proteomics, vol. 14, no. 6, pp. 699-712.
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Nielsen, EJB, Nielsen, JM, Becker, D, Karlas, A, Prakash, H
, Glud, SZ, Merrison, J, Besenbacher, F, Meyer, TF
, Kjems, J & Howard, KA 2010, '
Pulmonary gene silencing in transgenic EGFP mice using aerosolised chitosan/siRNA nanoparticles',
Pharmaceutical Research, vol. 27, no. 12, pp. 2520-7.
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Gonzalez, BB, Dagnæs-Hansen, F, Fenton, RA, Gao, S, Hein, S, Dong, M, Kjems, J & Howard, KA 2013, '
Protection and systemic translocation of siRNA following oral administration of chitosan/siRNA nanoparticles',
Molecular Therapy - Nucleic Acids, vol. 2, no. 1, e76, pp. 1-8.
https://doi.org/10.1038/mtna.2013.2
Mandrup, OA, Ong, SC, Lykkemark, S, Dinesen, A, Rudnik-Jansen, I, Dagnæs-Hansen, NF, Andersen, JT, Alvarez-Vallina, L
& Howard, KA 2021, '
Programmable half-life and anti-tumour effects of bispecific T-cell engager-albumin fusions with tuned FcRn affinity',
Communications Biology, vol. 4, no. 1, 310.
https://doi.org/10.1038/s42003-021-01790-2
Nawroth, I, Alsner, J, Deleuran, BW, Dagnæs-Hansen, F, Yang, C, Horsman, MR, Overgaard, J, Howard, K, Kjems, J & Gao, S 2013, '
Peritoneal macrophages mediated delivery of chitosan/siRNA nanoparticle to the lesion site in a murine radiation-induced fibrosis model',
Acta Oncologica, vol. 52, no. 8, pp. 1730-1738.
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Walther, R, Monge, P, Pedersen, A, Benderoth, A, Pedersen, J, Farzadfard, A, Mandrup, O, Howard, K, Otzen, D & Zelikin, AN 2021, '
Per-glycosylation of the Surface-Accessible Lysines: One-Pot Aqueous Route to Stabilized Proteins with Native Activity',
ChemBioChem, vol. 22, no. 14, pp. 2478-2485.
https://doi.org/10.1002/cbic.202100228
Blans, KIM, Hansen, MS, Sørensen, LV
, Hvam, ML, Howard, K, Möller, A, Wiking, L, Larsen, LB & Rasmussen, JT 2017, '
Pellet-free isolation of human and bovine milk extracellular vesicles by size-exclusion chromatography',
Journal of Extracellular Vesicles, vol. 6, no. 1, 1294340.
https://doi.org/10.1080/20013078.2017.1294340
Cai, Y, Makarova, A-M, Wengel, J
& Howard, K 2018, '
Palmitoylated phosphodiester gapmer designs with albumin binding capacity and maintained in vitro gene silencing activity',
Journal of Gene Medicine, vol. 20, no. 7-8, e3025.
https://doi.org/10.1002/jgm.3025
Hall, A, Nicholls , K, Caspersen , MB
, Skrivergaard, S, Howard, K, Karu, K, Chudasama, V & Baker, JR 2019, '
Optimised approach to albumin-drug conjugates using monobromomaleimide-C-2 linkers',
Organic & Biomolecular Chemistry, vol. 17, no. 34, pp. 7870-7873.
https://doi.org/10.1039/C9OB00721KPetersen, S, Kläning, E, Andersen, B, Cameron, J
, Sørensen, ES & Howard, K 2016, '
Neonatal Fc Receptor Binding Tolerance toward the Covalent Conjugation of Payloads to Cysteine 34 of Human Albumin Variants',
Molecular Pharmaceutics, vol. 13, no. 2, pp. 677–682.
https://doi.org/10.1021/acs.molpharmaceut.5b00605
Howard, KA, Dong, M, Oupicky, D, Bisht, HS, Buss, C
, Besenbacher, F & Kjems, J 2007, '
Nanocarrier stimuli-activated gene delivery',
Small, vol. 3, no. 1, pp. 54-7.
https://doi.org/10.1002/smll.200600328
Hemmingsen, JK, Whitehead, B, Howard, K & Nejsum, PL 2025, '
Nanobudbringere til hjernen: Et nyt våben mod sclerose',
Aktuel Naturvidenskab, vol. 2025, no. 4.
Glud, SZ, Bramsen, JB, Dagnaes-Hansen, F, Wengel, J
, Howard, KA, Nyengaard, JR & Kjems, J 2009, '
Naked siLNA-mediated gene silencing of lung bronchoepithelium EGFP expression after intravenous administration',
Oligonucleotides, vol. 19, no. 2, pp. 163-8.
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