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 iNANO About Research Groups Biofilm group (Meyer)

Biofilm group (Prof. Rikke Louise Meyer)

The group

My research combines microbiology and nanotechnology in pursuit of understanding how biofilms establish, and how they can be controlled.

  • Investigation of fundamental mechanisms in bacterial adhesion and biofilm formation, particularly the role of extracellular DNA.
  • Development of new approaches to  control biofilms and treat biofilm infections through targeted drug delivery, novel antibiotics and nanobiotics, and non-biocidal biofilm control with e.g. enzymes or salinity oscillation.

2025 highligts

Ajunwa, O. M., Minero, G. A. S., Jensen, S. D. & Meyer, R. L. (2025). Hemin-binding DNA structures on the surface of bacteria promote extracellular electron transfer. Nucleic Acids Research, 53(15), Article gkaf790. https://doi.org/10.1093/nar/gkaf790

Dybtved, M. S., Petersen, M. E., Firdausy, A. F., Johansen, M. I., Faddy, E., Gadeberg, C., Østergaard, L., Jørgensen, N. P., Glud, L. N., Søgaard, A. B., Meyer, R. L. & Zelikin, A. N. (2025). Broad-Spectrum Antimicrobial Treatment Targeted Through Drug Conjugation to Vancomycin. Advanced Healthcare Materials, Article e03932. Advance online publication. https://doi.org/10.1002/adhm.202503932

Evans, D. C. S., Kristensen, M. F., Minero, G. A. S., Palmén, L. G., Knap, I., Tiwari, M. K., Schlafer, S. & Meyer, R. L. (2025). Dental biofilms contain DNase I-resistant Z-DNA and G-quadruplexes but alternative DNase overcomes this resistance. npj Biofilms and Microbiomes, 11(1), Article 80. https://doi.org/10.1038/s41522-025-00694-x

Petersen, M. E., Khamas, A. B., Østergaard, L. J., Jørgensen, N. P. & Meyer, R. L. (2025). Combination therapy delays antimicrobial resistance after adaptive laboratory evolution of Staphylococcus aureus. Antimicrobial Agents and Chemotherapy, 69(4), Article e01483-24. https://doi.org/10.1128/aac.01483-24

Del Rey, Y. C., Rikvold, P. D., Lund, M. B., Raittio, E. J., Schramm, A., Meyer, R. L. & Schlafer, S. (2025). Arginine modulates the pH, microbial composition, and matrix architecture of biofilms from caries-active patients. International Journal of Oral Science, 17(1), Article 70. https://doi.org/10.1038/s41368-025-00404-5

Recent publications

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Pandit, S., Jacquemin, L., Zhang, J., Gao, Z., Nishina, Y., Meyer, R. L., Mijakovic, I., Bianco, A. & Pang, C. (2023). Polymyxin B complexation enhances the antimicrobial potential of graphene oxide. Frontiers in cellular and infection microbiology, 13, Article 1209563. https://doi.org/10.3389/fcimb.2023.1209563
Ghorbani, S., Christine Füchtbauer, A., Møllebjerg, A., Møller Martensen, P., Hvidbjerg Laursen, S., Christian Evar Kraft, D., Kjems, J., Meyer, R. L., Rahimi, K., Foss, M., Füchtbauer, E. M. & Sutherland, D. S. (2023). Protein ligand and nanotopography separately drive the phenotype of mouse embryonic stem cells. Biomaterials, 301, Article 122244. https://doi.org/10.1016/j.biomaterials.2023.122244
Schlafer, S., K. Johnsen, K., Jørgensen, M.-R., Kjærbølling, I., Schramm, A. & Meyer, R. L. (2023). The effect of an enzyme-containing lozenge on dental biofilm accumulation: A clinical pilot study. Caries Research, 57(3), 445-445. Article 158. https://doi.org/10.1159/000534630
Schlafer, S., K. Johnsen, K., Jørgensen, M.-R., Kjærbølling, I., Schramm, A. & Meyer, R. L. (2023). The effect of an enzyme-containing lozenge on dental biofilm accumulation: A clinical pilot study. Abstract from ORCA: 70th Congress of the European Organization for Caries Research, Egmond aan Zee, Netherlands.
Ommen, P., Hansen, L., Hansen, B. K., Vu-Quang, H., Kjems, J. & Meyer, R. L. (2022). Aptamer-Targeted Drug Delivery for Staphylococcus aureus Biofilm. Frontiers in cellular and infection microbiology, 12, Article 814340. https://doi.org/10.3389/fcimb.2022.814340
Afshar, M., Møllebjerg, A., Minero, G. A., Hollensteiner, J., Poehlein, A., Himmelbach, A., Lange, J., Meyer, R. L. & Brüggemann, H. (2022). Biofilm formation and inflammatory potential of Staphylococcus saccharolyticus: A possible cause of orthopedic implant-associated infections. Frontiers in Microbiology, 13, Article 1070201. https://doi.org/10.3389/fmicb.2022.1070201
Møllebjerg, A. & Meyer, R. L. (2022). Biofouling Control in Water Filtration Systems. In Antibiofilm Strategies: Current and Future Applications to Prevent, Control and Eradicate Biofilms (pp. 521–551). Springer. https://doi.org/10.1007/978-3-031-10992-8_20

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Collaborations with industry

Revised 04.02.2026
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Lise Refstrup Linnebjerg Pedersen