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JULIÁN VALERO: Functionalising RNA

Julián Valero is passionate about nucleic acids (DNA, RNA and XNA). His research group focuses on a unique angle that combines cutting edge nanotechnology tools, nucleic acid chemistry and in vitro evolution techniques to develop novel nucleic acid systems that display a wide variety of functionalities. In particular, they employ new chemistries that enable them to expand the genetic lexicon and chemical space compared to Nature´s toolbox. With this in hand, the group can design synthetic biology systems that can establish novel interactions, molecular dynamics, communications and synapses, and use them for studying biologically relevant processes or for therapeutic targeting.

Recent publications

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Haydell, M. W., Centola, M., Adam, V., Valero Moreno, J. & Famulok, M. (2018). Temporal and Reversible Control of a DNAzyme by Orthogonal Photoswitching. Journal of the American Chemical Society, 140(49), 16868-16872. https://doi.org/10.1021/jacs.8b08738
Vinther, S. C., Resag, A., Le, K. T. T., Zelle-Rieser, C. C., Strandt, H., Malle, M. G., Christiansen, S. H., Del Frari, B., Stigger, T., Schilling, B., Wohlfarth, J., Thiel, S., Valero, J., Stoitzner, P. & Kjems, J. (2026). Targeting Langerhans cells using a modular mannosylated nucleic acid-based vaccine platform. Journal of Controlled Release, 392, 114741. Article 114741. https://doi.org/10.1016/j.jconrel.2026.114741
Moradzadeh, N., Jonczyk, A., Schmitz, A., Fieberg, V., Civit, L., Valero, J., Famulok, M. & Mayer, G. (2026). Selection and Characterization of SARS-CoV-2 Spike Binding Clickmers. ChemBioChem, 27(1), Article e202500733. https://doi.org/10.1002/cbic.202500733