Søren Degn

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He, M., D'Aulerio, R., Pinho, L. G., Doukoumopoulos, E., Yong, T., Vieira, R. C., Oliveira, M. M. S., Eiben, L., Termote, M., Galvani, R. G., Sedimbi, S., Seitz, C., Kuznetsov, N. V., Zuriaga, M. A., Kitamura, D., Fuster, J. J., Cotta-de-Almeida, V., Ström, L., Dosenovic, P. ... Westerberg, L. S. (2026). AID and TET2 cooperate to demethylate Irf4 for plasma cell fate in germinal center B cells. The Journal of Experimental Medicine, 223(6). https://doi.org/10.1084/jem.20260096

Pedersen, K., Green, K., Kristoffersen, E. L., Schinkel, T., Hansen, A. G., Palarasah, Y., Rovsing, A. B., Andersen, E. S., Valero, J., Civit, L., Laursen, N. S., Troldborg, A., Degn, S. E. & Thiel, S. (2026). Curbing Autoimmunity: A New Fab Fragment Targeting CD40-CD40L Halts B-Cell Activation and Differentiation. European Journal of Immunology, 56(2), Article e70158. https://doi.org/10.1002/eji.70158

Pohl, L., Wittenborn, T. R., Shahrokhtash, A., Kastberg, K. S., Fahlquist-Hagert, C., Jensen, L., Pedersen, S. A., Demtröder, J. K., Sardella, D., Pulfer, A., Sutherland, D., Gonzalez, S. F., Schiessl, I. M. & Degn, S. E. (2026). Serial intravital microscopy reveals temporal dynamics of autoreactive germinal centers in the spleen. iScience, 29(4), Article 115340. https://doi.org/10.1016/j.isci.2026.115340

Morsing, A. E., Green, K., Clausen, S., Benjaminsen, C. R., Blaavand, M. S., Demtröder, J. K., Skraep, J., Jensen, L., Breining, P., Kjolby, M., Vendelbo, M., Degn, S. E. & Thomsen, M. K. (2025). Age-associated B cells enhance tertiary lymphoid structures in the liver and promote HCC formation. Hepatology Communications, 9(10), Article e0816. https://doi.org/10.1097/HC9.0000000000000816

Pilati, D., Agyei, E. K., Elkhashab, M., Fuchs, E., Nielsen, I. H., Bjerg, T. W., Anthi, A. K., Jiménez-Reinoso, A., Iversen, M. B., Pohl, L., Narita, R., Frago, S., Jakobsen, M. R., Andersen, J. T., Degn, S. E., Paludan, S. R., Alvarez-Vallina, L. & Howard, K. A. (2025). Exploiting FcRn engagement of an albumin-CpG oligonucleotide covalent conjugate for potent TLR9 immune induction. Journal of Biological Chemistry, 301(6), Article 108508. https://doi.org/10.1016/j.jbc.2025.108508

Rasmussen, M. Q., Bønnelykke-Behrndtz, M. L., Merrild, C., Tvilling, I. K. S., Christensen, J. N., Nielsen, M. M., Georgsen, J. B., Naumann, N., Gudbergsson, J. M., Etzerodt, A., Pedersen, J. S., Jenkins, R. W., Degn, S. E., Moestrup, S. K., Schmidt, H., Steiniche, T. & Madsen, M. (2025). LRP2 Expression in Melanoma Is Associated With a Transitory Cell State, Increased T Cell Infiltration, and Is Upregulated by IFNy Signaling. Pigment Cell & Melanoma Research, 38(5), Article e70053. https://doi.org/10.1111/pcmr.70053

Fonager, S. V., Winther, G., Weber, Y. C. L., Wittenborn, T. R., Kastberg, K. S., Terczyńska-Dyla, E., Jensen, L., Hansen, L. A., Carroll, M. C., Luo, Y., Lin, L. & Degn, S. E. (2025). Maternal imprinting of autoreactivity in a murine model of systemic lupus erythematosus. Brain, Behavior, and Immunity, 129, 921-934. https://doi.org/10.1016/j.bbi.2025.07.025

Rovsing, A. B., Green, K., Jensen, L., Nielsen, I. H., Mikkelsen, J. G. & Degn, S. E. (2025). Multiparametric Optimization of Human Primary B-Cell Cultures Using Design of Experiments. Scandinavian Journal of Immunology, 102(2), Article e70043. https://doi.org/10.1111/sji.70043

Degn, S. E. & Tolar, P. (2025). Towards a unifying model for B-cell receptor triggering. Nature Reviews Immunology, 25(2), 77-91. Article 976. https://doi.org/10.1038/s41577-024-01073-x

Nielsen, I. H., Rovsing, A. B., Janns, J. H., Thomsen, E. A., Ruzo, A., Bøggild, A., Nedergaard, F., Møller, C. T., Boesen, T., Degn, S. E., Shah, J. V. & Mikkelsen, J. G. (2024). Cell-targeted gene modification by delivery of CRISPR-Cas9 ribonucleoprotein complexes in pseudotyped lentivirus-derived nanoparticles. Molecular Therapy Nucleic Acids, 35(4), Article 102318. https://doi.org/10.1016/j.omtn.2024.102318

Fahlquist-Hagert, C., Wittenborn, T. R., Ferapontov, A., Jensen, L., Terczyńska-Dyla, E. & Degn, S. E. (2024). Haplosufficiency of MHCII in autoreactive germinal center B cells. European Journal of Immunology, 54(1), Article 2350422. https://doi.org/10.1002/eji.202350422

Fahlquist-Hagert, C., Wittenborn, T. R., Pedersen, M. K., Jensen, L. & Degn, S. E. (2024). T-follicular regulatory cells expand to control germinal center plasma cell output but fail to curb autoreactivity. iScience, 27(10), Article 110887. https://doi.org/10.1016/j.isci.2024.110887

Krimpenfort, L. T., Degn, S. E. & Heesters, B. A. (2024). The follicular dendritic cell: At the germinal center of autoimmunity? Cell Reports, 43(3), Article 113869. https://doi.org/10.1016/j.celrep.2024.113869

Ferapontov, A., Omer, M., Baudrexel, I., Nielsen, J. S., Dupont, D. M., Juul-Madsen, K., Steen, P., Eklund, A. S., Thiel, S., Vorup-Jensen, T., Jungmann, R., Kjems, J. & Degn, S. E. (2023). Antigen footprint governs activation of the B cell receptor. Nature Communications, 14(1), Article 976. https://doi.org/10.1038/s41467-023-36672-0

Fahlquist-Hagert, C., Wittenborn, T. R., Terczyńska-Dyla, E., Kastberg, K. S., Yang, E., Rallistan, A. N., Markett, Q. R., Winther, G., Fonager, S., Voss, L. F., Pedersen, M. K., van Campen, N., Ferapontov, A., Jensen, L., Huang, J., Nieland, J. D., van der Poel, C. E., Palmfeldt, J., Carroll, M. C. ... Degn, S. E. (2023). Antigen presentation by B cells enables epitope spreading across an MHC barrier. Nature Communications, 14(1), Article 6941. https://doi.org/10.1038/s41467-023-42541-7

Wibrand, C., Wittenborn, T. R., Voss, L. F., Winther, G., Jensen, L., Ferapontov, A., Fonager, S. V., Fahlquist-Hagert, C. & Degn, S. E. (2023). B cell MHC haplotype affects follicular inclusion, germinal center participation and plasma cell differentiation in a mouse model of lupus. Frontiers in Immunology, 14, Article 1258046. https://doi.org/10.3389/fimmu.2023.1258046

Rasmussen, M. Q., Tindbæk, G., Nielsen, M. M., Merrild, C., Steiniche, T., Pedersen, J. S., Moestrup, S. K., Degn, S. E. & Madsen, M. (2023). Epigenetic Silencing of LRP2 Is Associated with Dedifferentiation and Poor Survival in Multiple Solid Tumor Types. Cancers, 15(6), Article 1830. https://doi.org/10.3390/cancers15061830

Brandt, C. B., Fonager, S. V., Haskó, J., Helmig, R. B., Degn, S., Bolund, L., Jessen, N., Lin, L. & Luo, Y. (2023). HIF1A Knockout by Biallelic and Selection-Free CRISPR Gene Editing in Human Primary Endothelial Cells with Ribonucleoprotein Complexes. Biomolecules, 13(1), Article 23. https://doi.org/10.3390/biom13010023

Joseph, J. V., Blaavand, M. S., Cai, H., Vernejoul, F., Knopper, R. W., Lindhardt, T. B., Skipper, K. A., Axelgaard, E., Reinert, L., Mikkelsen, J. G., Borghammer, P., Degn, S. E., Perouzel, E., Hager, H., Hansen, B., Kalucka, J. M., Vendelbo, M., Paludan, S. R. & Thomsen, M. K. (2023). STING activation counters glioblastoma by vascular alteration and immune surveillance. Cancer Letters, 579, Article 216480. https://doi.org/10.1016/j.canlet.2023.216480

Sirinian, C., Papanastasiou, A. D., Karayel, O., Degn, S. E., Peroukidis, S., Chaniotis, D., Nonni, A., Repanti, M., Kriegsmann, M., Makatsoris, T., Koutras, A., Mann, M. & Kalofonos, H. P. (2022). Analysis of RANK-c interaction partners identifies TRAF3 as a critical regulator of breast cancer aggressiveness. NeoPlasia, 33, Article 100836. https://doi.org/10.1016/j.neo.2022.100836

Fonager, S. V., Winther, G., Wittenborn, T. R., Jensen, L., Fahlquist-Hagert, C., Hansen, L. A., Füchtbauer, E.-M., Romero-Ramos, M. & Degn, S. E. (2022). Increased maternofoetal transfer of antibodies in a murine model of systemic lupus erythematosus, but no immune activation and neuroimmune sequelae in offspring. Journal of Neuroimmunology, 370, Article 577927. https://doi.org/10.1016/j.jneuroim.2022.577927

Voss, L. F., Howarth, A. J., Wittenborn, T. R., Hummelgaard, S., Juul-Madsen, K., Kastberg, K. S., Pedersen, M. K., Jensen, L., Papanastasiou, A. D., Vorup-Jensen, T., Weyer, K. & Degn, S. E. (2022). The extrafollicular response is sufficient to drive initiation of autoimmunity and early disease hallmarks of lupus. Frontiers in Immunology, 13, Article 1021370. https://doi.org/10.3389/fimmu.2022.1021370

Green, K., Wittenborn, T. R., Fahlquist-Hagert, C., Terczynska-Dyla, E., van Campen, N., Jensen, L., Reinert, L., Hartmann, R., Paludan, S. R. & Degn, S. E. (2021). B Cell Intrinsic STING Signaling Is Not Required for Autoreactive Germinal Center Participation. Frontiers in Immunology, 12, Article 782558. https://doi.org/10.3389/fimmu.2021.782558

Juul-Madsen, K., Troldborg, A., Wittenborn, T. R., Axelsen, M. G., Zhao, H., Klausen, L. H., Luecke, S., Paludan, S. R., Stengaard-Pedersen, K., Dong, M., Møller, H. J., Thiel, S., Jensen, H., Schuck, P., Sutherland, D. S., Degn, S. E. & Vorup-Jensen, T. (2021). Characterization of DNA-protein complexes by nanoparticle tracking analysis and their association with systemic lupus erythematosus. Proceedings of the National Academy of Sciences (PNAS), 118(30), Article e2106647118. https://doi.org/10.1073/pnas.2106647118

Wittenborn, T. R., Hagert, C. F., Ferapontov, A., Fonager, S., Jensen, L., Winther, G. & Degn, S. E. (2021). Comparison of gamma and x-ray irradiation for myeloablation and establishment of normal and autoimmune syngeneic bone marrow chimeras. PLoS One, 16(3), Article e0247501. https://doi.org/10.1371/journal.pone.0247501

Sirinian, C., Papanastasiou, A. D., Degn, S. E., Frantzi, T., Aronis, C., Chaniotis, D., Makatsoris, T., Koutras, A. & Kalofonos, H. P. (2021). Rank-c expression sensitizes er-negative, egfr-positive breast cancer cells to egfr-tyrosine kinase inhibitors (Tkis). Genes, 12(11), Article 1686. https://doi.org/10.3390/genes12111686

Hagert, C. F., Bohn, A. B., Wittenborn, T. R. & Degn, S. E. (2020). Seeing the Confetti Colors in a New Light Utilizing Flow Cytometry and Imaging Flow Cytometry. Cytometry. Part A, 97(8), 811-823. https://doi.org/10.1002/cyto.a.24032

Fahlquist Hagert, C. & Degn, S. E. (2020). T follicular regulatory cells: Guardians of the germinal centre? Scandinavian Journal of Immunology, 92(4), Article e12942. https://doi.org/10.1111/sji.12942

van der Poel, C. E., Bajic, G., Macaulay, C. W., van den Broek, T., Ellson, C. D., Bouma, G., Victora, G. D., Degn, S. E. & Carroll, M. C. (2019). Follicular Dendritic Cells Modulate Germinal Center B Cell Diversity through FcγRIIB. Cell Reports, 29(9), 2745-2755.e4. https://doi.org/10.1016/j.celrep.2019.10.086

Wittenborn, T. R., Hagert, C. & Degn, S. E. (2019). Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity. Journal of visualized experiments : JoVE, 2019(146), Article e59397. https://doi.org/10.3791/59397

Degn, S. E., Alicot, E. & Carroll, M. C. (2018). B cell tolerance to epidermal ribonuclear-associated neo-autoantigen in vivo. Clinical and Experimental Immunology, 191(2), 151-165. https://doi.org/10.1111/cei.13066

Firl, D. J., Degn, S. E., Padera, T. & Carroll, M. C. (2018). Capturing change in clonal composition amongst single mouse germinal centers. eLife, 7, Article e33051. https://doi.org/10.7554/eLife.33051

Psianou, K., Panagoulias, I., Papanastasiou, A. D., de Lastic, A.-L., Rodi, M., Spantidea, P. I., Degn, S. E., Georgiou, P. & Mouzaki, A. (2018). Clinical and immunological parameters of Sjögren's syndrome. Autoimmunity Reviews, 17(10), 1053-1064. https://doi.org/10.1016/j.autrev.2018.05.005

Degn, S. E., van der Poel, C. E., Firl, D. J., Ayoglu, B., Al Qureshah, F. A., Bajic, G., Mesin, L., Reynaud, C.-A., Weill, J.-C., Utz, P. J., Victora, G. D. & Carroll, M. C. (2017). Clonal Evolution of Autoreactive Germinal Centers. Cell, 170(5), 913-926.e19. https://doi.org/10.1016/j.cell.2017.07.026