He, M., D'Aulerio, R., Pinho, L. G., Doukoumopoulos, E., Yong, T., Vieira, R. C., Oliveira, M. M. S., Eiben, L., Termote, M., Galvani, R. G., Sedimbi, S., Seitz, C., Kuznetsov, N. V., Zuriaga, M. A., Kitamura, D., Fuster, J. J., Cotta-de-Almeida, V., Ström, L., Dosenovic, P. ... Westerberg, L. S. (2026).
AID and TET2 cooperate to demethylate Irf4 for plasma cell fate in germinal center B cells.
The Journal of Experimental Medicine,
223(6).
https://doi.org/10.1084/jem.20260096Wang, F., Ren, J., Zhou, Y., Huo, W., Liu, H., Qin, M., Jing, Y., Yin, Z., Shi, T., Shan, H., Tan, G., Wang, H., Guo, X., Mei, J., Yue, Z., Hou, Z., Zhou, H., Song, J.
, Degn, S. E. ... Jiang, Y. (2026).
Cross-species comparison of amniote single-cell transcriptomes reveals evolutionary conservation and divergence in the chicken immune system.
Nature Communications,
17(1).
https://doi.org/10.1038/s41467-026-72642-yPedersen, K., Green, K., Kristoffersen, E. L., Schinkel, T., Hansen, A. G., Palarasah, Y.
, Rovsing, A. B., Andersen, E. S., Valero, J., Civit, L., Laursen, N. S., Troldborg, A., Degn, S. E. & Thiel, S. (2026).
Curbing Autoimmunity: A New Fab Fragment Targeting CD40-CD40L Halts B-Cell Activation and Differentiation.
European Journal of Immunology,
56(2), Article e70158.
https://doi.org/10.1002/eji.70158
Sirinian, C., de Lastic, A. L., Zaverdas, H., Nifora, M., Georgakopoulou, D., Samiotaki, M., Argentou, M. I., Peroukidis, S.
, Degn, S. E., Rusan, M., Theofilatos, K., Mavroudi, S., Papanastasiou, A. D. & Koutras, A. (2026).
Dual Role of Cancer Epithelial-Specific TRAF3 in Regulating Breast Cancer Cell Survival and Lymphocyte Activity.
International Journal of Molecular Sciences ,
27(10), Article 4414.
https://doi.org/10.3390/ijms27104414Andersen, S., Assing, K., Jensen, J., Rasmussen, L. D., Laursen, C. B., Dellgren, C. D.
, Hinke, D. M., Degn, S. E. & Mogensen, T. H. (2026).
Oncostatin M receptor deficiency as a novel candidate genetic cause of autosomal recessive hyper-IgE syndrome.
Journal of human immunity,
2(3), Article e20250119.
https://doi.org/10.70962/jhi.20250119
Pohl, L., Wittenborn, T. R., Shahrokhtash, A., Kastberg, K. S., Fahlquist-Hagert, C., Jensen, L., Pedersen, S. A., Demtröder, J. K.
, Sardella, D., Pulfer, A.
, Sutherland, D., Gonzalez, S. F.
, Schiessl, I. M. & Degn, S. E. (2026).
Serial intravital microscopy reveals temporal dynamics of autoreactive germinal centers in the spleen.
iScience,
29(4), Article 115340.
https://doi.org/10.1016/j.isci.2026.115340
Morsing, A. E.
, Green, K., Clausen, S., Benjaminsen, C. R.
, Blaavand, M. S., Demtröder, J. K.
, Skraep, J., Jensen, L., Breining, P., Kjolby, M., Vendelbo, M., Degn, S. E. & Thomsen, M. K. (2025).
Age-associated B cells enhance tertiary lymphoid structures in the liver and promote HCC formation.
Hepatology Communications,
9(10), Article e0816.
https://doi.org/10.1097/HC9.0000000000000816Pilati, D., Agyei, E. K., Elkhashab, M., Fuchs, E., Nielsen, I. H., Bjerg, T. W., Anthi, A. K., Jiménez-Reinoso, A.
, Iversen, M. B., Pohl, L., Narita, R., Frago, S.
, Jakobsen, M. R., Andersen, J. T.
, Degn, S. E., Paludan, S. R., Alvarez-Vallina, L.
& Howard, K. A. (2025).
Exploiting FcRn engagement of an albumin-CpG oligonucleotide covalent conjugate for potent TLR9 immune induction.
Journal of Biological Chemistry,
301(6), Article 108508.
https://doi.org/10.1016/j.jbc.2025.108508
Rasmussen, M. Q., Bønnelykke-Behrndtz, M. L., Merrild, C., Tvilling, I. K. S., Christensen, J. N., Nielsen, M. M., Georgsen, J. B., Naumann, N., Gudbergsson, J. M., Etzerodt, A., Pedersen, J. S., Jenkins, R. W.
, Degn, S. E., Moestrup, S. K., Schmidt, H., Steiniche, T. & Madsen, M. (2025).
LRP2 Expression in Melanoma Is Associated With a Transitory Cell State, Increased T Cell Infiltration, and Is Upregulated by IFNy Signaling.
Pigment Cell & Melanoma Research,
38(5), Article e70053.
https://doi.org/10.1111/pcmr.70053
Fonager, S. V., Winther, G., Weber, Y. C. L., Wittenborn, T. R., Kastberg, K. S., Terczyńska-Dyla, E., Jensen, L., Hansen, L. A., Carroll, M. C.
, Luo, Y., Lin, L. & Degn, S. E. (2025).
Maternal imprinting of autoreactivity in a murine model of systemic lupus erythematosus.
Brain, Behavior, and Immunity,
129, 921-934.
https://doi.org/10.1016/j.bbi.2025.07.025
Rovsing, A. B., Green, K., Jensen, L., Nielsen, I. H., Mikkelsen, J. G. & Degn, S. E. (2025).
Multiparametric Optimization of Human Primary B-Cell Cultures Using Design of Experiments.
Scandinavian Journal of Immunology,
102(2), Article e70043.
https://doi.org/10.1111/sji.70043
Nielsen, I. H., Rovsing, A. B., Janns, J. H., Thomsen, E. A., Ruzo, A.
, Bøggild, A., Nedergaard, F., Møller, C. T., Boesen, T., Degn, S. E., Shah, J. V.
& Mikkelsen, J. G. (2024).
Cell-targeted gene modification by delivery of CRISPR-Cas9 ribonucleoprotein complexes in pseudotyped lentivirus-derived nanoparticles.
Molecular Therapy Nucleic Acids,
35(4), Article 102318.
https://doi.org/10.1016/j.omtn.2024.102318
Fahlquist-Hagert, C., Wittenborn, T. R., Ferapontov, A., Jensen, L., Terczyńska-Dyla, E. & Degn, S. E. (2024).
Haplosufficiency of MHCII in autoreactive germinal center B cells.
European Journal of Immunology,
54(1), Article 2350422.
https://doi.org/10.1002/eji.202350422
Fahlquist-Hagert, C., Wittenborn, T. R., Pedersen, M. K.
, Jensen, L. & Degn, S. E. (2024).
T-follicular regulatory cells expand to control germinal center plasma cell output but fail to curb autoreactivity.
iScience,
27(10), Article 110887.
https://doi.org/10.1016/j.isci.2024.110887
Ferapontov, A., Omer, M., Baudrexel, I.
, Nielsen, J. S., Dupont, D. M., Juul-Madsen, K., Steen, P., Eklund, A. S.
, Thiel, S., Vorup-Jensen, T., Jungmann, R.
, Kjems, J. & Degn, S. E. (2023).
Antigen footprint governs activation of the B cell receptor.
Nature Communications,
14(1), Article 976.
https://doi.org/10.1038/s41467-023-36672-0
Fahlquist-Hagert, C., Wittenborn, T. R., Terczyńska-Dyla, E., Kastberg, K. S., Yang, E., Rallistan, A. N., Markett, Q. R.
, Winther, G., Fonager, S., Voss, L. F., Pedersen, M. K.
, van Campen, N., Ferapontov, A., Jensen, L., Huang, J., Nieland, J. D., van der Poel, C. E.
, Palmfeldt, J., Carroll, M. C.
... Degn, S. E. (2023).
Antigen presentation by B cells enables epitope spreading across an MHC barrier.
Nature Communications,
14(1), Article 6941.
https://doi.org/10.1038/s41467-023-42541-7
Wibrand, C., Wittenborn, T. R., Voss, L. F., Winther, G., Jensen, L., Ferapontov, A., Fonager, S. V., Fahlquist-Hagert, C. & Degn, S. E. (2023).
B cell MHC haplotype affects follicular inclusion, germinal center participation and plasma cell differentiation in a mouse model of lupus.
Frontiers in Immunology,
14, Article 1258046.
https://doi.org/10.3389/fimmu.2023.1258046
Rasmussen, M. Q., Tindbæk, G., Nielsen, M. M., Merrild, C., Steiniche, T., Pedersen, J. S., Moestrup, S. K., Degn, S. E. & Madsen, M. (2023).
Epigenetic Silencing of LRP2 Is Associated with Dedifferentiation and Poor Survival in Multiple Solid Tumor Types.
Cancers,
15(6), Article 1830.
https://doi.org/10.3390/cancers15061830
Brandt, C. B., Fonager, S. V., Haskó, J., Helmig, R. B., Degn, S., Bolund, L., Jessen, N., Lin, L. & Luo, Y. (2023).
HIF1A Knockout by Biallelic and Selection-Free CRISPR Gene Editing in Human Primary Endothelial Cells with Ribonucleoprotein Complexes.
Biomolecules,
13(1), Article 23.
https://doi.org/10.3390/biom13010023
Joseph, J. V., Blaavand, M. S., Cai, H., Vernejoul, F.
, Knopper, R. W., Lindhardt, T. B., Skipper, K. A., Axelgaard, E., Reinert, L., Mikkelsen, J. G., Borghammer, P., Degn, S. E., Perouzel, E.
, Hager, H., Hansen, B., Kalucka, J. M., Vendelbo, M., Paludan, S. R. & Thomsen, M. K. (2023).
STING activation counters glioblastoma by vascular alteration and immune surveillance.
Cancer Letters,
579, Article 216480.
https://doi.org/10.1016/j.canlet.2023.216480
Sirinian, C., Papanastasiou, A. D., Karayel, O.
, Degn, S. E., Peroukidis, S., Chaniotis, D., Nonni, A., Repanti, M., Kriegsmann, M., Makatsoris, T., Koutras, A., Mann, M. & Kalofonos, H. P. (2022).
Analysis of RANK-c interaction partners identifies TRAF3 as a critical regulator of breast cancer aggressiveness.
NeoPlasia,
33, Article 100836.
https://doi.org/10.1016/j.neo.2022.100836Fonager, S. V., Winther, G., Wittenborn, T. R., Jensen, L., Fahlquist-Hagert, C., Hansen, L. A., Füchtbauer, E.-M., Romero-Ramos, M. & Degn, S. E. (2022).
Increased maternofoetal transfer of antibodies in a murine model of systemic lupus erythematosus, but no immune activation and neuroimmune sequelae in offspring.
Journal of Neuroimmunology,
370, Article 577927.
https://doi.org/10.1016/j.jneuroim.2022.577927
Voss, L. F., Howarth, A. J., Wittenborn, T. R., Hummelgaard, S., Juul-Madsen, K., Kastberg, K. S., Pedersen, M. K.
, Jensen, L., Papanastasiou, A. D.
, Vorup-Jensen, T., Weyer, K. & Degn, S. E. (2022).
The extrafollicular response is sufficient to drive initiation of autoimmunity and early disease hallmarks of lupus.
Frontiers in Immunology,
13, Article 1021370.
https://doi.org/10.3389/fimmu.2022.1021370
Green, K., Wittenborn, T. R., Fahlquist-Hagert, C., Terczynska-Dyla, E., van Campen, N., Jensen, L., Reinert, L., Hartmann, R., Paludan, S. R. & Degn, S. E. (2021).
B Cell Intrinsic STING Signaling Is Not Required for Autoreactive Germinal Center Participation.
Frontiers in Immunology,
12, Article 782558.
https://doi.org/10.3389/fimmu.2021.782558
Juul-Madsen, K., Troldborg, A., Wittenborn, T. R., Axelsen, M. G., Zhao, H.
, Klausen, L. H., Luecke, S., Paludan, S. R., Stengaard-Pedersen, K., Dong, M., Møller, H. J., Thiel, S., Jensen, H., Schuck, P.
, Sutherland, D. S., Degn, S. E. & Vorup-Jensen, T. (2021).
Characterization of DNA-protein complexes by nanoparticle tracking analysis and their association with systemic lupus erythematosus.
Proceedings of the National Academy of Sciences (PNAS),
118(30), Article e2106647118.
https://doi.org/10.1073/pnas.2106647118
Wittenborn, T. R., Hagert, C. F., Ferapontov, A., Fonager, S., Jensen, L., Winther, G. & Degn, S. E. (2021).
Comparison of gamma and x-ray irradiation for myeloablation and establishment of normal and autoimmune syngeneic bone marrow chimeras.
PLoS One,
16(3), Article e0247501.
https://doi.org/10.1371/journal.pone.0247501
Sirinian, C., Papanastasiou, A. D.
, Degn, S. E., Frantzi, T., Aronis, C., Chaniotis, D., Makatsoris, T., Koutras, A. & Kalofonos, H. P. (2021).
Rank-c expression sensitizes er-negative, egfr-positive breast cancer cells to egfr-tyrosine kinase inhibitors (Tkis).
Genes,
12(11), Article 1686.
https://doi.org/10.3390/genes12111686van der Poel, C. E., Bajic, G., Macaulay, C. W., van den Broek, T., Ellson, C. D., Bouma, G., Victora, G. D.
, Degn, S. E. & Carroll, M. C. (2019).
Follicular Dendritic Cells Modulate Germinal Center B Cell Diversity through FcγRIIB.
Cell Reports,
29(9), 2745-2755.e4.
https://doi.org/10.1016/j.celrep.2019.10.086Psianou, K., Panagoulias, I., Papanastasiou, A. D., de Lastic, A.-L., Rodi, M., Spantidea, P. I.
, Degn, S. E., Georgiou, P. & Mouzaki, A. (2018).
Clinical and immunological parameters of Sjögren's syndrome.
Autoimmunity Reviews,
17(10), 1053-1064.
https://doi.org/10.1016/j.autrev.2018.05.005Degn, S. E., van der Poel, C. E., Firl, D. J., Ayoglu, B., Al Qureshah, F. A., Bajic, G., Mesin, L., Reynaud, C.-A., Weill, J.-C., Utz, P. J., Victora, G. D. & Carroll, M. C. (2017).
Clonal Evolution of Autoreactive Germinal Centers.
Cell,
170(5), 913-926.e19.
https://doi.org/10.1016/j.cell.2017.07.026
Mortensen, S. A., Skov, L. L., Kjaer-Sorensen, K., Hansen, A. G., Hansen, S., Dagnæs-Hansen, F., Jensenius, J. C., Oxvig, C., Thiel, S. & Degn, S. E. (2017).
Endogenous Natural Complement Inhibitor Regulates Cardiac Development.
Journal of Immunology,
198(8), 3118-3126.
https://doi.org/10.4049/jimmunol.1601958
Bajic, G., Degn, S. E., Thiel, S. & Andersen, G. R. (2015).
Complement activation, regulation, and molecular basis for complement-related diseases.
EMBO Journal,
34(22), 2735-2757.
https://doi.org/10.15252/embj.201591881
Degn, S. E., Kjaer, T. R., Kidmose, R. T., Jensen, L., Hansen, A. G., Tekin, M.
, Jensenius, J. C., Andersen, G. R. & Thiel, S. (2014).
Complement activation by ligand-driven juxtaposition of discrete pattern recognition complexes.
Proceedings of the National Academy of Sciences (PNAS),
111(37), 13445-13450.
https://doi.org/10.1073/pnas.1406849111
Degn, S. E., Jensen, L., Olszowski, T.
, Jensenius, J. C. & Thiel, S. (2013).
Co-complexes of MASP-1 and MASP-2 associated with the soluble pattern-recognition molecules drive lectin pathway activation in a manner inhibitable by MAp44.
Journal of Immunology,
191(3), 1334-45.
https://doi.org/10.4049/jimmunol.1300780
Chatterjee, P., Agyemang, A. F., Alimzhanov, M. B.
, Degn, S. E., Tsiftsoglou, S. A., Alicot, E., Jones, S. A., Ma, M. & Carroll, M. C. (2013).
Complement C4 maintains peripheral B-cell tolerance in a myeloid cell dependent manner.
European Journal of Immunology,
43(9), 2441-50.
https://doi.org/10.1002/eji.201343412Brinkmann, C. R., Jensen, L., Dagnaes-Hansen, F., Holm, I. E., Endo, Y., Fujita, T.
, Thiel, S., Jensenius, J. C. & Degn, S. E. (2013).
Mitochondria and the lectin pathway of complement.
Journal of Biological Chemistry.
https://doi.org/10.1074/jbc.M112.430249
Degn, S. E., Jensen, L., Hansen, A. G., Duman, D., Tekin, M.
, Jensenius, J. C. & Thiel, S. (2012).
Mannan-Binding Lectin-Associated Serine Protease (MASP)-1 Is Crucial for Lectin Pathway Activation in Human Serum, whereas neither MASP-1 nor MASP-3 Is Required for Alternative Pathway Function.
Journal of Immunology,
189(8), 3957-69.
https://doi.org/10.4049/jimmunol.1201736
Thiel, S., Jensen, L., Degn, S. E., Nielsen, H. J., Gál, P., Dobó, J.
& Jensenius, J. C. (2012).
Mannan-binding lectin (MBL)-associated serine protease-1 (MASP-1), a serine protease associated with humoral pattern-recognition molecules: normal and acute-phase levels in serum and stoichiometry of lectin pathway components.
Clinical and Experimental Immunology, Supplement,
169(1), 38-48.
https://doi.org/10.1111/j.1365-2249.2012.04584.x
