Søren Degn

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Nielsen, I. H., Rovsing, A. B., Janns, J. H., Thomsen, E. A., Ruzo, A., Bøggild, A., Nedergaard, F., Møller, C. T., Boesen, T., Degn, S. E., Shah, J. V. & Mikkelsen, J. G. (2024). Cell-targeted gene modification by delivery of CRISPR-Cas9 ribonucleoprotein complexes in pseudotyped lentivirus-derived nanoparticles. Molecular Therapy Nucleic Acids, 35(4), Article 102318. https://doi.org/10.1016/j.omtn.2024.102318

Fahlquist-Hagert, C., Wittenborn, T. R., Pedersen, M. K., Jensen, L. & Degn, S. E. (2024). T-follicular regulatory cells expand to control germinal center plasma cell output but fail to curb autoreactivity. iScience, 27(10), Article 110887. https://doi.org/10.1016/j.isci.2024.110887

Krimpenfort, L. T., Degn, S. E. & Heesters, B. A. (2024). The follicular dendritic cell: At the germinal center of autoimmunity? Cell Reports, 43(3), Article 113869. https://doi.org/10.1016/j.celrep.2024.113869

Ferapontov, A., Omer, M., Baudrexel, I., Nielsen, J. S., Dupont, D. M., Juul-Madsen, K., Steen, P., Eklund, A. S., Thiel, S., Vorup-Jensen, T., Jungmann, R., Kjems, J. & Degn, S. E. (2023). Antigen footprint governs activation of the B cell receptor. Nature Communications, 14(1), Article 976. https://doi.org/10.1038/s41467-023-36672-0

Fahlquist-Hagert, C., Wittenborn, T. R., Terczyńska-Dyla, E., Kastberg, K. S., Yang, E., Rallistan, A. N., Markett, Q. R., Winther, G., Fonager, S., Voss, L. F., Pedersen, M. K., van Campen, N., Ferapontov, A., Jensen, L., Huang, J., Nieland, J. D., van der Poel, C. E., Palmfeldt, J., Carroll, M. C. ... Degn, S. E. (2023). Antigen presentation by B cells enables epitope spreading across an MHC barrier. Nature Communications, 14(1), Article 6941. https://doi.org/10.1038/s41467-023-42541-7

Rasmussen, M. Q., Tindbæk, G., Nielsen, M. M., Merrild, C., Steiniche, T., Pedersen, J. S., Moestrup, S. K., Degn, S. E. & Madsen, M. (2023). Epigenetic Silencing of LRP2 Is Associated with Dedifferentiation and Poor Survival in Multiple Solid Tumor Types. Cancers, 15(6), Article 1830. https://doi.org/10.3390/cancers15061830

Joseph, J. V., Blaavand, M. S., Cai, H., Vernejoul, F., Knopper, R. W., Lindhardt, T. B., Skipper, K. A., Axelgaard, E., Reinert, L., Mikkelsen, J. G., Borghammer, P., Degn, S. E., Perouzel, E., Hager, H., Hansen, B., Kalucka, J. M., Vendelbo, M., Paludan, S. R. & Thomsen, M. K. (2023). STING activation counters glioblastoma by vascular alteration and immune surveillance. Cancer Letters, 579, Article 216480. https://doi.org/10.1016/j.canlet.2023.216480

Sirinian, C., Papanastasiou, A. D., Karayel, O., Degn, S. E., Peroukidis, S., Chaniotis, D., Nonni, A., Repanti, M., Kriegsmann, M., Makatsoris, T., Koutras, A., Mann, M. & Kalofonos, H. P. (2022). Analysis of RANK-c interaction partners identifies TRAF3 as a critical regulator of breast cancer aggressiveness. NeoPlasia, 33, Article 100836. https://doi.org/10.1016/j.neo.2022.100836

Brandt, C. B., Fonager, S. V., Haskó, J., Helmig, R. B., Degn, S., Bolund, L., Jessen, N., Lin, L. & Luo, Y. (2022). HIF1A Knockout by Biallelic and Selection-Free CRISPR Gene Editing in Human Primary Endothelial Cells with Ribonucleoprotein Complexes. Biomolecules, 13(1), Article 23. https://doi.org/10.3390/biom13010023

Fonager, S. V., Winther, G., Wittenborn, T. R., Jensen, L., Fahlquist-Hagert, C., Hansen, L. A., Füchtbauer, E.-M., Romero-Ramos, M. & Degn, S. E. (2022). Increased maternofoetal transfer of antibodies in a murine model of systemic lupus erythematosus, but no immune activation and neuroimmune sequelae in offspring. Journal of Neuroimmunology, 370, Article 577927. https://doi.org/10.1016/j.jneuroim.2022.577927

Voss, L. F., Howarth, A. J., Wittenborn, T. R., Hummelgaard, S., Juul-Madsen, K., Kastberg, K. S., Pedersen, M. K., Jensen, L., Papanastasiou, A. D., Vorup-Jensen, T., Weyer, K. & Degn, S. E. (2022). The extrafollicular response is sufficient to drive initiation of autoimmunity and early disease hallmarks of lupus. Frontiers in Immunology, 13, Article 1021370. https://doi.org/10.3389/fimmu.2022.1021370

Green, K., Wittenborn, T. R., Fahlquist-Hagert, C., Terczynska-Dyla, E., van Campen, N., Jensen, L., Reinert, L., Hartmann, R., Paludan, S. R. & Degn, S. E. (2021). B Cell Intrinsic STING Signaling Is Not Required for Autoreactive Germinal Center Participation. Frontiers in Immunology, 12, Article 782558. https://doi.org/10.3389/fimmu.2021.782558

Juul-Madsen, K., Troldborg, A., Wittenborn, T. R., Axelsen, M. G., Zhao, H., Klausen, L. H., Luecke, S., Paludan, S. R., Stengaard-Pedersen, K., Dong, M., Møller, H. J., Thiel, S., Jensen, H., Schuck, P., Sutherland, D. S., Degn, S. E. & Vorup-Jensen, T. (2021). Characterization of DNA-protein complexes by nanoparticle tracking analysis and their association with systemic lupus erythematosus. Proceedings of the National Academy of Sciences (PNAS), 118(30), Article e2106647118. https://doi.org/10.1073/pnas.2106647118

Wittenborn, T. R., Hagert, C. F., Ferapontov, A., Fonager, S., Jensen, L., Winther, G. & Degn, S. E. (2021). Comparison of gamma and x-ray irradiation for myeloablation and establishment of normal and autoimmune syngeneic bone marrow chimeras. PLOS ONE, 16(3), Article e0247501. https://doi.org/10.1371/journal.pone.0247501

Sirinian, C., Papanastasiou, A. D., Degn, S. E., Frantzi, T., Aronis, C., Chaniotis, D., Makatsoris, T., Koutras, A. & Kalofonos, H. P. (2021). Rank-c expression sensitizes er-negative, egfr-positive breast cancer cells to egfr-tyrosine kinase inhibitors (Tkis). Genes, 12(11), Article 1686. https://doi.org/10.3390/genes12111686

Hagert, C. F., Bohn, A. B., Wittenborn, T. R. & Degn, S. E. (2020). Seeing the Confetti Colors in a New Light Utilizing Flow Cytometry and Imaging Flow Cytometry. Cytometry. Part A, 97(8), 811-823. https://doi.org/10.1002/cyto.a.24032

Fahlquist Hagert, C. & Degn, S. E. (2020). T follicular regulatory cells: Guardians of the germinal centre? Scandinavian Journal of Immunology, 92(4), Article e12942. https://doi.org/10.1111/sji.12942

van der Poel, C. E., Bajic, G., Macaulay, C. W., van den Broek, T., Ellson, C. D., Bouma, G., Victora, G. D., Degn, S. E. & Carroll, M. C. (2019). Follicular Dendritic Cells Modulate Germinal Center B Cell Diversity through FcγRIIB. Cell Reports, 29(9), 2745-2755.e4. https://doi.org/10.1016/j.celrep.2019.10.086

Wittenborn, T. R., Hagert, C. & Degn, S. E. (2019). Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity. Journal of visualized experiments : JoVE, 2019(146), Article e59397. https://doi.org/10.3791/59397

Degn, S. E., Alicot, E. & Carroll, M. C. (2018). B cell tolerance to epidermal ribonuclear-associated neo-autoantigen in vivo. Clinical and Experimental Immunology, 191(2), 151-165. https://doi.org/10.1111/cei.13066

Firl, D. J., Degn, S. E., Padera, T. & Carroll, M. C. (2018). Capturing change in clonal composition amongst single mouse germinal centers. eLife, 7, Article e33051. https://doi.org/10.7554/eLife.33051

Psianou, K., Panagoulias, I., Papanastasiou, A. D., de Lastic, A.-L., Rodi, M., Spantidea, P. I., Degn, S. E., Georgiou, P. & Mouzaki, A. (2018). Clinical and immunological parameters of Sjögren's syndrome. Autoimmunity Reviews, 17(10), 1053-1064. https://doi.org/10.1016/j.autrev.2018.05.005

Degn, S. E., van der Poel, C. E., Firl, D. J., Ayoglu, B., Al Qureshah, F. A., Bajic, G., Mesin, L., Reynaud, C.-A., Weill, J.-C., Utz, P. J., Victora, G. D. & Carroll, M. C. (2017). Clonal Evolution of Autoreactive Germinal Centers. Cell, 170(5), 913-926. https://doi.org/10.1016/j.cell.2017.07.026

Mortensen, S. A., Skov, L. L., Kjaer-Sorensen, K., Hansen, A. G., Hansen, S., Dagnæs-Hansen, F., Jensenius, J. C., Oxvig, C., Thiel, S. & Degn, S. E. (2017). Endogenous Natural Complement Inhibitor Regulates Cardiac Development. Journal of Immunology, 198(8), 3118-3126. https://doi.org/10.4049/jimmunol.1601958

Degn, S. E., van der Poel, C. E. & Carroll, M. C. (2017). Targeting autoreactive germinal centers to curb autoimmunity. OncoTarget, 8(53), 90624. https://doi.org/10.18632/oncotarget.21701

Bajic, G., Degn, S. E., Thiel, S. & Andersen, G. R. (2015). Complement activation, regulation, and molecular basis for complement-related diseases. E M B O Journal, 34(22), 2735-2757. https://doi.org/10.15252/embj.201591881

Degn, S. E., Kjaer, T. R., Kidmose, R. T., Jensen, L., Hansen, A. G., Tekin, M., Jensenius, J. C., Andersen, G. R. & Thiel, S. (2014). Complement activation by ligand-driven juxtaposition of discrete pattern recognition complexes. Proceedings of the National Academy of Sciences (PNAS), 111(37), 13445-13450. https://doi.org/10.1073/pnas.1406849111

Degn, S. E., Jensenius, J. C. & Thiel, S. (2014). The pro-factor D cleaving activity of MASP-1/-3 is not required for alternative pathway function. Journal of Immunology, 192(12), 5447-8. https://doi.org/10.4049/jimmunol.1400777

Degn, S. E., Jensen, L., Olszowski, T., Jensenius, J. C. & Thiel, S. (2013). Co-complexes of MASP-1 and MASP-2 associated with the soluble pattern-recognition molecules drive lectin pathway activation in a manner inhibitable by MAp44. Journal of Immunology, 191(3), 1334-45. https://doi.org/10.4049/jimmunol.1300780

Chatterjee, P., Agyemang, A. F., Alimzhanov, M. B., Degn, S. E., Tsiftsoglou, S. A., Alicot, E., Jones, S. A., Ma, M. & Carroll, M. C. (2013). Complement C4 maintains peripheral B-cell tolerance in a myeloid cell dependent manner. European Journal of Immunology, 43(9), 2441-50. https://doi.org/10.1002/eji.201343412

Degn, S. E. & Thiel, S. (2013). Humoral pattern recognition and the complement system. Scandinavian Journal of Immunology, 78(2), 181-93. https://doi.org/10.1111/sji.12070

Brinkmann, C. R., Jensen, L., Dagnaes-Hansen, F., Holm, I. E., Endo, Y., Fujita, T., Thiel, S., Jensenius, J. C. & Degn, S. E. (2013). Mitochondria and the lectin pathway of complement. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.M112.430249

Degn, S. E., Thiel, S. & Jensenius, J. C. (2013). Recombinant expression of the autocatalytic complement protease MASP-1 is crucially dependent on co-expression with its inhibitor, C1 inhibitor. Protein Expression and Purification, 88(2), 173-182. https://doi.org/10.1016/j.pep.2013.01.002

Degn, S. E., Jensenius, J. C. & Thiel, S. (2013). Response to comment on "Mannan-binding lectin-associated serine protease (MASP)-1 is crucial for lectin pathway activation in human serum, whereas neither MASP-1 nor MASP-3 is required for alternative pathway function". Journal of Immunology, 190(6), 2477-8. https://doi.org/10.4049/jimmunol.1390003

Degn, S. E., Jensen, L., Hansen, A. G., Duman, D., Tekin, M., Jensenius, J. C. & Thiel, S. (2012). Mannan-Binding Lectin-Associated Serine Protease (MASP)-1 Is Crucial for Lectin Pathway Activation in Human Serum, whereas neither MASP-1 nor MASP-3 Is Required for Alternative Pathway Function. Journal of Immunology, 189(8), 3957-69. https://doi.org/10.4049/jimmunol.1201736

Thiel, S., Jensen, L., Degn, S. E., Nielsen, H. J., Gál, P., Dobó, J. & Jensenius, J. C. (2012). Mannan-binding lectin (MBL)-associated serine protease-1 (MASP-1), a serine protease associated with humoral pattern-recognition molecules: normal and acute-phase levels in serum and stoichiometry of lectin pathway components. Clinical and Experimental Immunology. Supplement, 169(1), 38-48. https://doi.org/10.1111/j.1365-2249.2012.04584.x

Degn, S. E., Andersen, S. H., Jensen, L., Thiel, S. & Jensenius, J. C. (2011). Assay interference caused by antibodies reacting with rat kappa light-chain in human sera. Journal of Immunological Methods, 372(1-2), 204-8. https://doi.org/10.1016/j.jim.2011.06.030

Degn, S. E., Jensenius, J. C. & Thiel, S. (2011). Disease-causing mutations in genes of the complement system. American Journal of Human Genetics, 88(6), 689-705. https://doi.org/10.1016/j.ajhg.2011.05.011

Degn, S. E., Thiel, S., Nielsen, O., Hansen, A. G., Steffensen, R. & Jensenius, J. C. (2011). MAp19, the alternative splice product of the MASP2 gene. Journal of Immunological Methods, 373(1-2), 89-101. https://doi.org/10.1016/j.jim.2011.08.006

Gonzalez, S. F., Degn, S. E., Pitcher, L. A., Woodruff, M., Heesters, B. A. & Carroll, M. C. (2011). Trafficking of B cell antigen in lymph nodes. Annual Review of Immunology, 29, 215-233.

Degn, S. E., Jensen, L., Gál, P., Dobó, J., Holmvad, S. H., Jensenius, J. C. & Thiel, S. (2010). Biological variations of MASP-3 and MAp44, two splice products of the MASP1 gene involved in regulation of the complement system. Journal of Immunological Methods, 361(1-2), 37-50. https://doi.org/10.1016/j.jim.2010.07.006

Gonzalez, S. F., Lukacs-Kornek, V., Kuligowski, M. P., Pitcher, L. A., Degn, S. E., Kim, Y.-A., Cloninger, M. J., Martinez-Pomares, L., Gordon, S., Turley, S. J. & Carroll, M. C. (2010). Capture of influenza by medullary dendritic cells via SIGN-R1 is essential for humoral immunity in draining lymph nodes. Nature Immunology, 11(5), 427-435.

Gonzalez, S. F., Lukacs-Kornek, V., Kuligowski, M. P., Pitcher, L. A., Degn, S. E., Turley, S. J. & Carroll, M. C. (2010). Complement-dependent transport of antigen into B cell follicles. Journal of Immunology, 185, 2659-2664.

Degn, S. E., Jensenius, J. C. & Bjerre, M. (2010). The lectin pathway and its implications in coagulation, infections and auto-immunity. Current Opinion in Organ Transplantation. https://doi.org/10.1097/MOT.0b013e32834253df

Degn, S. E. (2010). The Lectin Pathway Serine Proteases and Associated Proteins. Århus Universitet.

Degn, S. E., Hansen, A., Steffensen, R., Jacobsen, C., Jensenius, J. C. & Thiel, S. (2009). MAp44, a human protein associated with pattern recognition molecules of the complement system and regulating the lectin pathway of complement activation. Journal of Immunology, 183(11), 7371-8. https://doi.org/10.4049/jimmunol.0902388

Thiel, S., Kolev, M., Degn, S. E., Steffensen, R., Hansen, A., Ruseva, M. & Jensenius, J. C. (2009). Polymorphisms in mannan-binding lectin (MBL)-associated serine protease 2 affect stability, binding to MBL, and enzymatic activity. Journal of Immunology, 182(5), 2939-47. https://doi.org/10.4049/jimmunol.0802053

Degn, S. E., Thiel, S. & Jensenius, J. C. (2007). New perspectives on mannan-binding lectin-mediated complement activation. Immunobiology, 212, 301-11.

Revised 17.04.2023

Anne Færch Nielsen

Interdisciplinary Nanoscience Center

CellPAT

Søren Degn