Krissanaprasit, A., Mihalko, E., Meinhold, K., Simpson, A., Sollinger, J., Pandit, S., Dupont, D. M., Kjems, J., Brown, A. C. & LaBean, T. H. (2024). A functional RNA-origami as direct thrombin inhibitor with fast-acting and specific single-molecule reversal agents in vivo model. Molecular Therapy, 32(7), 2286-2298. https://doi.org/10.1016/j.ymthe.2024.05.002

Civit, L., Moradzadeh, N., Jonczyk, A., Neckermann, P., Asbach, B., Peterhoff, D., Wagner, R., Famulok, M., Mayer, G., Kjems, J. & Valero, J. (2024). A Multi-Faceted Binding Assessment of Aptamers Targeting the SARS-CoV-2 Spike Protein. International Journal of Molecular Sciences , 25(9), Article 4642. https://doi.org/10.3390/ijms25094642

Dinesen, A., Andersen, V. L., Elkhashab, M., Pilati, D., Bech, P., Fuchs, E., Samuelsen, T. R., Winther, A., Cai, Y., Märcher, A., Wall, A., Omer, M., Nielsen, J. S., Chudasama, V., Baker, J. R., Gothelf, K. V., Wengel, J., Kjems, J. & Howard, K. A. (2024). An Albumin-Holliday Junction Biomolecular Modular Design for Programmable Multifunctionality and Prolonged Circulation. Bioconjugate Chemistry, 35(2), 214-222. https://doi.org/10.1021/acs.bioconjchem.3c00491

Vieira de Sá, R., Sudria-Lopez, E., Cañizares Luna, M., Harschnitz, O., van den Heuvel, D. M. A., Kling, S., Vonk, D., Westeneng, H. J., Karst, H., Bloemenkamp, L., Varderidou-Minasian, S., Schlegel, D. K., Mars, M., Broekhoven, M. H., van Kronenburg, N. C. H., Adolfs, Y., Vangoor, V. R., de Jongh, R., Ljubikj, T. ... Pasterkamp, R. J. (2024). ATAXIN-2 intermediate-length polyglutamine expansions elicit ALS-associated metabolic and immune phenotypes. Nature Communications, 15(1), Article 7484. https://doi.org/10.1038/s41467-024-51676-0

Okholm, T. L. H., Kamstrup, A. B., Nielsen, M. M., Hollensen, A. K., Graversgaard, M. L., Sørensen, M. H., Kristensen, L. S., Vang, S., Park, S. S., Yeo, E., Dyrskjøt, L., Kjems, J., Pedersen, J. S. & Damgaard, C. K. (2024). circHIPK3 nucleates IGF2BP2 and functions as a competing endogenous RNA. eLife, 13, Article RP91783. https://doi.org/10.7554/eLife.91783

Rybiczka-Tešulov, M., Garritsen, O., Venø, M. T., Wieg, L., Dijk, R. V., Rahimi, K., Gomes-Duarte, A., Wit, M. D., van de Haar, L. L., Michels, L., van Kronenburg, N. C. H., van der Meer, C., Kjems, J., Vangoor, V. R. & Pasterkamp, R. J. (2024). Circular RNAs regulate neuron size and migration of midbrain dopamine neurons during development. Nature Communications, 15(1), Article 6773. https://doi.org/10.1038/s41467-024-51041-1

Scoyni, F., Sitnikova, V., Giudice, L., Korhonen, P., Trevisan, D. M., Hernandez de Sande, A., Gomez-Budia, M., Giniatullina, R., Ugidos, I. F., Dhungana, H., Pistono, C., Korvenlaita, N., Välimäki, N. N., Kangas, S. M., Hiltunen, A. E., Gribchenko, E., Kaikkonen-Määttä, M. U., Koistinaho, J., Ylä-Herttuala, S. ... Malm, T. (2024). ciRS-7 and miR-7 regulate ischemia-induced neuronal death via glutamatergic signaling. Cell Reports, 43(3), Article 113862. https://doi.org/10.1016/j.celrep.2024.113862

Vangoor, V. R., Giuliani, G., de Wit, M., Rangel, C. K., Venø, M. T., Schulte, J. T., Gomes-Duarte, A., Senthilkumar, K., Puhakka, N., Kjems, J., de Graan, P. N. E. & Pasterkamp, R. J. (2024). Compartment-specific small non-coding RNA changes and nucleolar defects in human mesial temporal lobe epilepsy. Acta Neuropathologica, 148(1), Article 61. https://doi.org/10.1007/s00401-024-02817-8

Zhang, X., Malle, M. G., Thomsen, R. P., Sørensen, R. S., Sørensen, E. W., Hatzakis, N. S. & Kjems, J. (2024). Deconvoluting the Effect of Cell-Penetrating Peptides for Enhanced and Controlled Insertion of Large-Scale DNA Nanopores. A C S Applied Materials and Interfaces, 16(15), 18422-18433. https://doi.org/10.1021/acsami.3c18636

Smidt, J. M., Märcher, A., Skaanning, M. K., El-Chami, K., Teodori, L., Omer, M., Kjems, J. & Gothelf, K. V. (2024). Dual-Targeting of the HER2 Cancer Receptor with an Antibody-Directed Enzyme and a Nanobody-Guided MMAE Prodrug Scaffold. ChemBioChem, 25(18), Article e202400437. https://doi.org/10.1002/cbic.202400437

Khemka, N., Morris, G., Kazemzadeh, L., Costard, L. S., Neubert, V., Bauer, S., Rosenow, F., Venø, M. T., Kjems, J., Henshall, D. C., Prehn, J. H. M. & Connolly, N. M. C. (2024). Integrative network analysis of miRNA-mRNA expression profiles during epileptogenesis in rats reveals therapeutic targets after emergence of first spontaneous seizure. Scientific Reports, 14(1), Article 15313. https://doi.org/10.1038/s41598-024-66117-7

Teodori, L., Kroer, S., Omer, M., Andersen, V. L., Bech, P., Su, J., Bridoux, J., Nielsen, J. S., Bertelsen, M. B., Hernot, S., Gothelf, K. V. & Kjems, J. (2024). Plug-and-play nucleic acid-mediated multimerization of biparatopic nanobodies for molecular imaging. Molecular Therapy - Nucleic Acids, 35(3), Article 102305. https://doi.org/10.1016/j.omtn.2024.102305

Malle, M. G., Song, P., Löffler, P. M. G., Kalisi, N., Yan, Y., Valero, J., Vogel, S. & Kjems, J. (2024). Programmable RNA Loading of Extracellular Vesicles with Toehold-Release Purification. Journal of the American Chemical Society, 146(18), 12410-12422. https://doi.org/10.1021/JACS.3C13123

Teodori, L., Omer, M. & Kjems, J. (2024). RNA nanostructures for targeted drug delivery and imaging. RNA Biology, 21(1), 1-19. https://doi.org/10.1080/15476286.2024.2328440

Bobbili, M. R., Görgens, A., Yan, Y., Vogt, S., Gupta, D., Corso, G., Barbaria, S., Patrioli, C., Weilner, S., Pultar, M., Jacak, J., Hackl, M., Schosserer, M., Grillari, R., Kjems, J., Andaloussi, S. E. L. & Grillari, J. (2024). Snorkel-tag based affinity chromatography for recombinant extracellular vesicle purification. Journal of Extracellular Vesicles, 13(10), Article e12523. https://doi.org/10.1002/jev2.12523

Orr, M. E., Kulasinghe, A., Kolar, G. R., Heyn, H., Plummer, J., Sommer Kristensen, L., Kjems, J., Mills, G., Garcia-Vallejo, J. J., Nijman, I. J., West, N. P. & Cox, A. (2024). Sounding an Alarm over Spatial Biology. Genetic Engineering and Biotechnology News, 44(3), 16-17. https://doi.org/10.1089/gen.44.03.07

Korhonen, S., Stenberg, K., Seemab, U., Bartos, P., Mäkiniemi, K., Kjems, J., Dupont, D. M. & Subrizi, A. (2024). Targeting ocular tissues with intravenously administered aptamers selected by in vivo SELEX. Molecular Therapy Nucleic Acids, 35(4), Article 102352. https://doi.org/10.1016/j.omtn.2024.102352

Korsgaard, U., García-Rodríguez, J. L., Jakobsen, T., Ahmadov, U., Dietrich, K. G., Vissing, S. M., Paasch, T. P., Lindebjerg, J., Kjems, J., Hager, H. & Kristensen, L. S. (2024). The Transcriptional Landscape of Coding and Noncoding RNAs in Recurrent and Nonrecurrent Colon Cancer. American Journal of Pathology, 194(8), 1424-1442. https://doi.org/10.1016/j.ajpath.2024.04.003

Jørgensen, A. G., Dupont, D. M., Fjelstrup, S., Bus, C., Hansen, C. B., Benfield, T., Garred, P., Heegaard, P. M. H. & Kjems, J. (2024). Unbiased plasma profiling using pre-selected RNA aptamer pools predicts mortality in COVID-19 and identifies protein risk factors. Molecular Therapy Nucleic Acids, 35(3), Article 102253. https://doi.org/10.1016/j.omtn.2024.102253

Seeler, S., Andersen, M. S., Sztanka-Toth, T., Rybiczka-Tešulov, M., van den Munkhof, M. H., Chang, C. C., Maimaitili, M., Venø, M. T., Hansen, T. B., Pasterkamp, R. J., Rybak-Wolf, A., Denham, M., Rajewsky, N., Kristensen, L. S. & Kjems, J. (2023). A Circular RNA Expressed from the FAT3 Locus Regulates Neural Development. Molecular Neurobiology, 60(6), 3239–3260. https://doi.org/10.1007/s12035-023-03253-7

Ferapontov, A., Omer, M., Baudrexel, I., Nielsen, J. S., Dupont, D. M., Juul-Madsen, K., Steen, P., Eklund, A. S., Thiel, S., Vorup-Jensen, T., Jungmann, R., Kjems, J. & Degn, S. E. (2023). Antigen footprint governs activation of the B cell receptor. Nature Communications, 14(1), Article 976. https://doi.org/10.1038/s41467-023-36672-0

Catapano, C., Rahm, J. V., Omer, M., Teodori, L., Kjems, J., Dietz, M. S. & Heilemann, M. (2023). Biased activation of the receptor tyrosine kinase HER2. Cellular and Molecular Life Sciences, 80(6), Article 158. https://doi.org/10.1007/s00018-023-04806-8

Tolomeo, D., Traversa, D., Venuto, S., Ebbesen, K., Garcia Rodriguez, J. L., Tamma, G., Ranieri, M., Simonetti, G., Ghetti, M., Paganelli, M., Visci, G., Liso, A., Kok, K., Muscarella, L. A., Fabrizio, F. P., Frassanito, M. A., Lamanuzzi, A., Saltarella, I., Solimando, A. G. ... Storlazzi, C. T. (2023). circPVT1 and PVT1/AKT3 show a role in cell proliferation, apoptosis, and tumor subtype-definition in Small Cell Lung Cancer. Genes, Chromosomes & Cancer, 62(7), 377-391. https://doi.org/10.1002/gcc.23121

Wedge, E., Ahmadov, U., Hansen, T. B., Gao, Z., Tulstrup, M., Côme, C., Nonavinkere Srivatsan, S., Ahmed, T., Jespersen, J. S., Schlotmann, B. C., Schöllkopf, C., Raaschou-Jensen, K., Ødum, N., Kjems, J., Bak, R. O., Walter, M. J., Grønbæk, K. & Kristensen, L. S. (2023). Impact of U2AF1 mutations on circular RNA expression in myelodysplastic neoplasms. Leukemia, 37(5), 1113-1125. https://doi.org/10.1038/s41375-023-01866-4

Heiland, M., Connolly, N. M. C., Mamad, O., Nguyen, N. T., Kesavan, J. C., Langa, E., Fanning, K., Sanfeliu, A., Yan, Y., Su, J., Venø, M. T., Costard, L. S., Neubert, V., Engel, T., Hill, T. D. M., Freiman, T. M., Mahesh, A., Tiwari, V. K., Rosenow, F. ... Henshall, D. C. (2023). MicroRNA-335-5p suppresses voltage-gated sodium channel expression and may be a target for seizure control. Proceedings of the National Academy of Sciences (PNAS), 120(30), e2216658120. Article e2216658120. https://doi.org/10.1073/pnas.2216658120

Ghorbani, S., Christine Füchtbauer, A., Møllebjerg, A., Møller Martensen, P., Hvidbjerg Laursen, S., Christian Evar Kraft, D., Kjems, J., Meyer, R. L., Rahimi, K., Foss, M., Füchtbauer, E. M. & Sutherland, D. S. (2023). Protein ligand and nanotopography separately drive the phenotype of mouse embryonic stem cells. Biomaterials, 301, Article 122244. https://doi.org/10.1016/j.biomaterials.2023.122244

García-Rodríguez, J. L., Korsgaard, U., Ahmadov, U., Jarlstad Olesen, M. T., Dietrich, K.-G., Hansen, E. B., Vissing, S. M., Ulhøi, B. P., Dyrskjøt, L., Sørensen, K. D., Kjems, J., Hager, H. & Kristensen, L. S. (2023). Spatial profiling of circular RNAs in cancer reveals high expression in muscle and stromal cells. Cancer Research, 83(20), 3340–3353. https://doi.org/10.1158/0008-5472.CAN-23-0748

Zhang, X., Galenkamp, N. S., Heide, N. J. V. D., Valero Moreno, J., Maglia, G. & Kjems, J. (2023). Specific Detection of Proteins by a Nanobody-Functionalized Nanopore Sensor. ACS Nano, 17(10), 9167-9177. https://doi.org/10.1021/acsnano.2c12733

Reinhold, D., Farztdinov, V., Yan, Y., Meisel, C., Sadlowski, H., Kühn, J., Perschel, F. H., Endres, M., Düzel, E., Vielhaber, S., Guttek, K., Goihl, A., Venø, M., Teegen, B., Stöcker, W., Stubbemann, P., Kurth, F., Sander, L. E., Ralser, M. ... Körtvelyessy, P. (2023). The brain reacting to COVID-19: analysis of the cerebrospinal fluid proteome, RNA and inflammation. Journal of Neuroinflammation, 20, Article 30. https://doi.org/10.1186/s12974-023-02711-2

Fuchs, E., Rudnik-Jansen, I., Dinesen, A., Selnihhin, D., Mandrup, O. A., Thiam, K., Kjems, J., Pedersen, F. S. & Howard, K. A. (2022). An albumin-angiotensin converting enzyme 2-based SARS-CoV-2 decoy with FcRn-driven half-life extension. Acta Biomaterialia, 153, 411-418. https://doi.org/10.1016/j.actbio.2022.09.048

Ommen, P., Hansen, L., Hansen, B. K., Vu-Quang, H., Kjems, J. & Meyer, R. L. (2022). Aptamer-Targeted Drug Delivery for Staphylococcus aureus Biofilm. Frontiers in cellular and infection microbiology, 12, Article 814340. https://doi.org/10.3389/fcimb.2022.814340

Nielsen, A. F., Bindereif, A., Bozzoni, I., Hanan, M., Hansen, T. B., Irimia, M., Kadener, S., Kristensen, L. S., Legnini, I., Morlando, M., Olesen, M. T. J., Pasterkamp, R. J., Preibisch, S., Rajewsky, N., Sünkel, C. & Kjems, J. (2022). Best practice standards for circular RNA research. Nature Methods, 19(10), 1208-1220. https://doi.org/10.1038/s41592-022-01487-2

Fjelstrup, S., Dupont, D. M., Bus, C., Enghild, J. J., Jensen, J. B., Birkenkamp-Demtröder, K., Dyrskjøt, L. & Kjems, J. (2022). Differential RNA aptamer affinity profiling on plasma as a potential diagnostic tool for bladder cancer. NAR cancer, 4(3), Article zcac025. https://doi.org/10.1093/narcan/zcac025

Gomes-Duarte, A., Venø, M. T., de Wit, M., Senthilkumar, K., Broekhoven, M. H., van den Herik, J., Heeres, F. R., van Rossum, D., Rybiczka-Tesulov, M., Legnini, I., van Rijen, P. C., van Eijsden, P., Gosselaar, P. H., Rajewsky, N., Kjems, J., Vangoor, V. R. & Pasterkamp, R. J. (2022). Expression of Circ_Satb1 Is Decreased in Mesial Temporal Lobe Epilepsy and Regulates Dendritic Spine Morphology. Frontiers in Molecular Neuroscience, 15, Article 832133. https://doi.org/10.3389/fnmol.2022.832133

Dahl, M., Husby, S., Eskelund, C. W., Besenbacher, S., Fjelstrup, S., Côme, C., Ek, S., Kolstad, A., Räty, R., Jerkeman, M., Geisler, C. H., Kjems, J., Kristensen, L. S. & Grønbæk, K. (2022). Expression patterns and prognostic potential of circular RNAs in mantle cell lymphoma: a study of younger patients from the MCL2 and MCL3 clinical trials. Leukemia, 36(1), 177-188. https://doi.org/10.1038/s41375-021-01311-4

Märcher, A., Kumar, V., Andersen, V. L., El-Chami, K., Nguyen, T. J. D., Skaanning, M. K., Rudnik-Jansen, I., Nielsen, J. S., Howard, K. A., Kjems, J. & Gothelf, K. V. (2022). Functionalized Acyclic (l)-Threoninol Nucleic Acid Four-Way Junction with High Stability In Vitro and In Vivo. Angewandte Chemie - International Edition, 61(24), Article 202115275. https://doi.org/10.1002/anie.202115275

Seeler, S., Moldovan, L.-I., Bertelsen, T., Hager, H., Iversen, L., Johansen, C., Kjems, J. & Sommer Kristensen, L. (2022). Global circRNA expression changes predate clinical and histological improvements of psoriasis patients upon secukinumab treatment. PLOS ONE, 17(9), Article e0275219. https://doi.org/10.1371/journal.pone.0275219

Teodori, L., Omer, M., Märcher, A., Skaanning, M. K., Andersen, V. L., Nielsen, J. S., Oldenburg, E., Lin, Y., Gothelf, K. V. & Kjems, J. (2022). Site-specific nanobody-oligonucleotide conjugation for super-resolution imaging. Journal of Biological Methods, 9(1), Article e159. https://doi.org/10.14440/jbm.2022.381

Kristensen, L. S., Jakobsen, T., Hager, H. & Kjems, J. (2022). The emerging roles of circRNAs in cancer and oncology. Nature Reviews. Clinical Oncology, 19(3), 188-206. https://doi.org/10.1038/s41571-021-00585-y

Khateb, H., Sørensen, R. S., Cramer, K., Eklund, A. S., Kjems, J., Meyer, R. L., Jungmann, R. & Sutherland, D. S. (2022). The Role of Nanoscale Distribution of Fibronectin in the Adhesion of Staphylococcus aureus Studied by Protein Patterning and DNA-PAINT. ACS Nano, 16(7), 10392-10403. https://doi.org/10.1021/acsnano.2c00630

Gu, T., Just, J., Stenz, K. T., Yan, Y., Sieljacks, P., Wang, J., Groennebaek, T. S., Jakobsgaard, J. E., Rindom, E., Herskind, J., Gravholt, A., Lassen, T. R., Jørgensen, M., Bæk, R., Gutiérrez-Jiménez, E., Iversen, N. K., Rasmussen, P. M., Nyengaard, J. R., Jørgensen, M. M. ... Drasbek, K. R. (2022). The Role of Plasma Extracellular Vesicles in Remote Ischemic Conditioning and Exercise-Induced Ischemic Tolerance. International Journal of Molecular Sciences , 23(6), Article 3334. https://doi.org/10.3390/ijms23063334

Hansen, E. K. B., Fredsøe, J. H., Okholm, T. L. H., Ulhøi, B. P., Klingenberg, S., Jensen, J. B., Kjems, J., Bouchelouche, K., Borre, M., Damgaard, C. K., Pedersen, J. S., Kristensen, L. S. & Sørensen, K. D. (2022). The transcriptional landscape and biomarker potential of circular RNAs in prostate cancer. Genome Medicine, 14(1), Article 8. https://doi.org/10.1186/s13073-021-01009-3

Vogt, S., Bobbili, M. R., Stadlmayr, G., Stadlbauer, K., Kjems, J., Rüker, F., Grillari, J. & Wozniak-Knopp, G. (2021). An engineered CD81-based combinatorial library for selecting recombinant binders to cell surface proteins: Laminin binding CD81 enhances cellular uptake of extracellular vesicles. Journal of Extracellular Vesicles, 10(11), Article e12139. https://doi.org/10.1002/jev2.12139

Valero, J., Civit, L., Dupont, D. M., Selnihhin, D., Reinert, L. S., Idorn, M., Israels, B. A., Bednarz, A. M., Bus, C., Asbach, B., Peterhoff, D., Pedersen, F. S., Birkedal, V., Wagner, R., Paludan, S. R. & Kjems, J. (2021). A serum-stable RNA aptamer specific for SARS-CoV-2 neutralizes viral entry. Proceedings of the National Academy of Sciences (PNAS), 118(50), Article e2112942118. https://doi.org/10.1073/pnas.2112942118