Seeler, S., Andersen, M. S., Sztanka-Toth, T., Rybiczka-Tešulov, M., van den Munkhof, M. H.
, Chang, C. C., Maimaitili, M., Venø, M. T., Hansen, T. B., Pasterkamp, R. J., Rybak-Wolf, A.
, Denham, M., Rajewsky, N.
, Kristensen, L. S. & Kjems, J. (2023).
A Circular RNA Expressed from the FAT3 Locus Regulates Neural Development.
Molecular Neurobiology,
60(6), 3239–3260.
https://doi.org/10.1007/s12035-023-03253-7
Ferapontov, A., Omer, M., Baudrexel, I.
, Nielsen, J. S., Dupont, D. M., Juul-Madsen, K., Steen, P., Eklund, A. S.
, Thiel, S., Vorup-Jensen, T., Jungmann, R.
, Kjems, J. & Degn, S. E. (2023).
Antigen footprint governs activation of the B cell receptor.
Nature Communications,
14(1), Article 976.
https://doi.org/10.1038/s41467-023-36672-0
Catapano, C., Rahm, J. V.
, Omer, M., Teodori, L., Kjems, J., Dietz, M. S. & Heilemann, M. (2023).
Biased activation of the receptor tyrosine kinase HER2.
Cellular and Molecular Life Sciences,
80(6), Article 158.
https://doi.org/10.1007/s00018-023-04806-8Tolomeo, D., Traversa, D., Venuto, S.
, Ebbesen, K., Garcia Rodriguez, J. L., Tamma, G., Ranieri, M., Simonetti, G., Ghetti, M., Paganelli, M., Visci, G., Liso, A., Kok, K., Muscarella, L. A., Fabrizio, F. P., Frassanito, M. A., Lamanuzzi, A., Saltarella, I., Solimando, A. G. ... Storlazzi, C. T. (2023).
circPVT1 and PVT1/AKT3 show a role in cell proliferation, apoptosis, and tumor subtype-definition in Small Cell Lung Cancer.
Genes, Chromosomes & Cancer,
62(7), 377-391.
https://doi.org/10.1002/gcc.23121Wedge, E.
, Ahmadov, U., Hansen, T. B., Gao, Z., Tulstrup, M., Côme, C., Nonavinkere Srivatsan, S., Ahmed, T., Jespersen, J. S., Schlotmann, B. C., Schöllkopf, C., Raaschou-Jensen, K., Ødum, N.
, Kjems, J., Bak, R. O., Walter, M. J., Grønbæk, K.
& Kristensen, L. S. (2023).
Impact of U2AF1 mutations on circular RNA expression in myelodysplastic neoplasms.
Leukemia,
37(5), 1113-1125. Advance online publication.
https://doi.org/10.1038/s41375-023-01866-4Heiland, M., Connolly, N. M. C., Mamad, O., Nguyen, N. T., Kesavan, J. C., Langa, E., Fanning, K., Sanfeliu, A.
, Yan, Y., Su, J., Venø, M. T., Costard, L. S., Neubert, V., Engel, T., Hill, T. D. M., Freiman, T. M., Mahesh, A., Tiwari, V. K., Rosenow, F. ... Henshall, D. C. (2023).
MicroRNA-335-5p suppresses voltage-gated sodium channel expression and may be a target for seizure control.
Proceedings of the National Academy of Sciences of the United States of America,
120(30), e2216658120.
https://doi.org/10.1073/pnas.2216658120Ghorbani, S., Christine Füchtbauer, A., Møllebjerg, A., Møller Martensen, P., Hvidbjerg Laursen, S., Christian Evar Kraft, D., Kjems, J., Meyer, R. L., Rahimi, K., Foss, M., Füchtbauer, E. M. & Sutherland, D. S. (2023).
Protein ligand and nanotopography separately drive the phenotype of mouse embryonic stem cells.
Biomaterials,
301, Article 122244.
https://doi.org/10.1016/j.biomaterials.2023.122244
García-Rodríguez, J. L., Korsgaard, U., Ahmadov, U., Jarlstad Olesen, M. T.
, Dietrich, K-G., Hansen, E. B.
, Vissing, S. M., Ulhøi, B. P., Dyrskjøt, L., Sørensen, K. D., Kjems, J., Hager, H. & Kristensen, L. S. (2023).
Spatial profiling of circular RNAs in cancer reveals high expression in muscle and stromal cells.
Cancer Research. Advance online publication.
https://doi.org/10.1158/0008-5472.CAN-23-0748
Zhang, X., Galenkamp, N. S., Heide, N. J. V. D.
, Valero Moreno, J., Maglia, G.
& Kjems, J. (2023).
Specific Detection of Proteins by a Nanobody-Functionalized Nanopore Sensor.
ACS Nano,
17(10), 9167-9177.
https://doi.org/10.1021/acsnano.2c12733
Reinhold, D., Farztdinov, V.
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The brain reacting to COVID-19: analysis of the cerebrospinal fluid proteome, RNA and inflammation.
Journal of Neuroinflammation,
20, Article 30.
https://doi.org/10.1186/s12974-023-02711-2Fuchs, E., Rudnik-Jansen, I., Dinesen, A., Selnihhin, D., Mandrup, O. A., Thiam, K.
, Kjems, J., Pedersen, F. S. & Howard, K. A. (2022).
An albumin-angiotensin converting enzyme 2-based SARS-CoV-2 decoy with FcRn-driven half-life extension.
Acta Biomaterialia,
153, 411-418.
https://doi.org/10.1016/j.actbio.2022.09.048
Ommen, P., Hansen, L., Hansen, B. K., Vu-Quang, H., Kjems, J. & Meyer, R. L. (2022).
Aptamer-Targeted Drug Delivery for Staphylococcus aureus Biofilm.
Frontiers in cellular and infection microbiology,
12, Article 814340.
https://doi.org/10.3389/fcimb.2022.814340
Staulund, J.
, Song, P., Qi, H., Thrane, L., Duedahl, P., Weiss, T., Moers, C.
, Keller, A. K., Nørregaard, R., Pedersen, M., Leuvenink, H.
, Kjems, J., Jespersen, B. & Eijken, M. (2022).
Assessing the quality of donor kidneys during normothermic machine perfusion using nanoparticle-based vitality sensors. Abstract from 3rd ECTORS meeting, Rotterdam, Netherlands.
Nielsen, A. F., Bindereif, A., Bozzoni, I., Hanan, M.
, Hansen, T. B., Irimia, M., Kadener, S.
, Kristensen, L. S., Legnini, I., Morlando, M.
, Olesen, M. T. J., Pasterkamp, R. J., Preibisch, S., Rajewsky, N., Sünkel, C.
& Kjems, J. (2022).
Best practice standards for circular RNA research.
Nature Methods,
19(10), 1208-1220. Advance online publication.
https://doi.org/10.1038/s41592-022-01487-2
Catapano, C., Rahm, J. V.
, Omer, M., Teodori, L., Kjems, J., Dietz, M. S. & Heilemann, M. (2022).
Biased activation of the receptor tyrosine kinase HER2. (pp. 2022.12.04.519064). bioRxiv.
https://doi.org/10.1101/2022.12.04.519064Fjelstrup, S., Dupont, D. M., Bus, C., Enghild, J. J., Jensen, J. B., Birkenkamp-Demtröder, K., Dyrskjøt, L. & Kjems, J. (2022).
Differential RNA aptamer affinity profiling on plasma as a potential diagnostic tool for bladder cancer.
NAR cancer,
4(3), Article zcac025.
https://doi.org/10.1093/narcan/zcac025
Gomes-Duarte, A.
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, Kjems, J., Vangoor, V. R. & Pasterkamp, R. J. (2022).
Expression of Circ_Satb1 Is Decreased in Mesial Temporal Lobe Epilepsy and Regulates Dendritic Spine Morphology.
Frontiers in Molecular Neuroscience,
15, Article 832133.
https://doi.org/10.3389/fnmol.2022.832133Dahl, M., Husby, S., Eskelund, C. W.
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, Kjems, J., Kristensen, L. S. & Grønbæk, K. (2022).
Expression patterns and prognostic potential of circular RNAs in mantle cell lymphoma: a study of younger patients from the MCL2 and MCL3 clinical trials.
Leukemia,
36(1), 177-188.
https://doi.org/10.1038/s41375-021-01311-4Østergaard, R. H., Yan, Y., Venø, M. T.
, Dinesen, A., Kjaer-Sorensen, K., Oxvig, C., Rasmussen, J. T., Howard, K., Kjems, J., van Niel, G., Verweij, F.
& Hayashi, Y. (2022).
Extracellular Vesicle Biology Meets Zebrafish: Real-Time Visualization and RNA Profiling of Physiological Exosomes in the Bloodstream. Poster session presented at The Danish Society for Extracellular Vesicles (DSEV) 3rd Annual Symposium 2022, Roskilde, Denmark.
Song, P., Staulund, J., Qi, H.
, Thrane, L., Pedersen, M., Eijken, M., Jespersen, B. & Kjems, J. (2022).
Ex-vivo mRNA therapy to predict kidney vitality during transplantation. Poster session presented at Danish RNA Society's 7th Annual Meeting, Aarhus, Denmark.
Märcher, A., Kumar, V., Andersen, V. L., El-Chami, K., Nguyen, T. J. D., Skaanning, M. K., Rudnik-Jansen, I., Nielsen, J. S., Howard, K. A., Kjems, J. & Gothelf, K. V. (2022).
Functionalized Acyclic (l)-Threoninol Nucleic Acid Four-Way Junction with High Stability In Vitro and In Vivo.
Angewandte Chemie - International Edition,
61(24), Article 202115275.
https://doi.org/10.1002/anie.202115275
Seeler, S., Moldovan, L-I., Bertelsen, T., Hager, H., Iversen, L., Johansen, C., Kjems, J. & Sommer Kristensen, L. (2022).
Global circRNA expression changes predate clinical and histological improvements of psoriasis patients upon secukinumab treatment.
PLOS ONE,
17(9), Article e0275219.
https://doi.org/10.1371/journal.pone.0275219
Teodori, L., Omer, M., Märcher, A., Skaanning, M. K., Andersen, V. L., Nielsen, J. S., Oldenburg, E., Lin, Y., Gothelf, K. V. & Kjems, J. (2022).
Site-specific nanobody-oligonucleotide conjugation for super-resolution imaging.
Journal of Biological Methods,
9(1), Article e159.
https://doi.org/10.14440/jbm.2022.381
Khateb, H., Sørensen, R. S., Cramer, K., Eklund, A. S.
, Kjems, J., Meyer, R. L., Jungmann, R.
& Sutherland, D. S. (2022).
The Role of Nanoscale Distribution of Fibronectin in the Adhesion of Staphylococcus aureus Studied by Protein Patterning and DNA-PAINT.
ACS Nano,
16(7), 10392-10403.
https://doi.org/10.1021/acsnano.2c00630
Gu, T., Just, J., Stenz, K. T., Yan, Y., Sieljacks, P., Wang, J., Groennebaek, T. S., Jakobsgaard, J. E., Rindom, E., Herskind, J., Gravholt, A.
, Lassen, T. R., Jørgensen, M., Bæk, R.
, Gutiérrez-Jiménez, E., Iversen, N. K., Rasmussen, P. M., Nyengaard, J. R., Jørgensen, M. M.
... Drasbek, K. R. (2022).
The Role of Plasma Extracellular Vesicles in Remote Ischemic Conditioning and Exercise-Induced Ischemic Tolerance.
International Journal of Molecular Sciences ,
23(6), Article 3334.
https://doi.org/10.3390/ijms23063334
Hansen, E. K. B., Fredsøe, J. H., Okholm, T. L. H., Ulhøi, B. P., Klingenberg, S., Jensen, J. B., Kjems, J., Bouchelouche, K., Borre, M., Damgaard, C. K., Pedersen, J. S., Kristensen, L. S. & Sørensen, K. D. (2022).
The transcriptional landscape and biomarker potential of circular RNAs in prostate cancer.
Genome Medicine,
14(1), Article 8.
https://doi.org/10.1186/s13073-021-01009-3
Vogt, S., Bobbili, M. R., Stadlmayr, G., Stadlbauer, K.
, Kjems, J., Rüker, F., Grillari, J. & Wozniak-Knopp, G. (2021).
An engineered CD81-based combinatorial library for selecting recombinant binders to cell surface proteins: Laminin binding CD81 enhances cellular uptake of extracellular vesicles.
Journal of Extracellular Vesicles,
10(11), Article e12139.
https://doi.org/10.1002/jev2.12139Valero, J., Civit, L., Dupont, D. M., Selnihhin, D., Reinert, L. S., Idorn, M., Israels, B. A., Bednarz, A. M., Bus, C., Asbach, B., Peterhoff, D.
, Pedersen, F. S., Birkedal, V., Wagner, R.
, Paludan, S. R. & Kjems, J. (2021).
A serum-stable RNA aptamer specific for SARS-CoV-2 neutralizes viral entry.
Proceedings of the National Academy of Sciences,
118(50), Article e2112942118.
https://doi.org/10.1073/pnas.2112942118
Lassen, T. R., Just, J., Hjortbak, M. V., Jespersen, N. R., Stenz, K. T., Gu, T., Yan, Y., Su, J., Hansen, J., Bæk, R., Jørgensen, M. M.
, Nyengaard, J. R., Kristiansen, S. B., Drasbek, K. R., Kjems, J. & Bøtker, H. E. (2021).
Cardioprotection by remote ischemic conditioning is transferable by plasma and mediated by extracellular vesicles.
Basic Research in Cardiology,
116(1), Article 16.
https://doi.org/10.1007/s00395-021-00856-w
Moldovan, L. I., Tsoi, L. C., Ranjitha, U., Hager, H., Weidinger, S., Gudjonsson, J. E.
, Kjems, J. & Kristensen, L. S. (2021).
Characterization of Circular RNA Transcriptomes in Psoriasis and Atopic Dermatitis Reveals Disease-specific Expression Profiles.
Experimental Dermatology,
30(8), 1187-1196. Advance online publication.
https://doi.org/10.1111/exd.14227
Yan, Y., Gu, T., Christensen, S. D. K., Su, J., Lassen, T. R., Hjortbak, M. V., Lo, I., Venø, S. T., Tóth, A. E., Song, P., Nielsen, M. S., Bøtker, H. E., Blagoev, B.
, Drasbek, K. R. & Kjems, J. (2021).
Cyclic hypoxia conditioning alters the content of myoblast-derived extracellular vesicles and enhances their cell-protective functions.
Biomedicines,
9(9), Article 1211.
https://doi.org/10.3390/biomedicines9091211
Ahmadov, U., Bendikas, M. M., Ebbesen, K. K., Sehested, A. M.
, Kjems, J., Broholm, H.
& Kristensen, L. S. (2021).
Distinct circular RNA expression profiles in pediatric ependymomas.
Brain Pathology,
31(2), 387-392.
https://doi.org/10.1111/bpa.12922
Gomes-Duarte, A., Bauer, S.
, Venø, M. T., Norwood, B. A., Henshall, D. C.
, Kjems, J., Rosenow, F., Vangoor, V. R. & Pasterkamp, R. J. (2021).
Enrichment of Circular RNA Expression Deregulation at the Transition to Recurrent Spontaneous Seizures in Experimental Temporal Lobe Epilepsy.
Frontiers in Genetics,
12, Article 627907.
https://doi.org/10.3389/fgene.2021.627907Jakobsen, T., Dahl, M., Dimopoulos, K., Grønbæk, K.
, Kjems, J. & Kristensen, L. S. (2021).
Genome-wide circular RNA expression patterns reflect resistance to immunomodulatory drugs in multiple myeloma cells.
Cancers,
13(3), Article 365.
https://doi.org/10.3390/cancers13030365
Krissanaprasit, A., Key, C. M., Froehlich, K., Pontula, S., Mihalko, E.
, Dupont, D. M., Andersen, E. S., Kjems, J., Brown, A. C. & LaBean, T. H. (2021).
Multivalent Aptamer-Functionalized Single-Strand RNA Origami as Effective, Target-Specific Anticoagulants with Corresponding Reversal Agents.
Advanced Healthcare Materials,
10(11), Article 2001826. Advance online publication.
https://doi.org/10.1002/adhm.202001826Lorenzi, L., Chiu, H. S., Avila Cobos, F., Gross, S., Volders, P. J., Cannoodt, R., Nuytens, J., Vanderheyden, K., Anckaert, J., Lefever, S., Tay, A. P., de Bony, E. J., Trypsteen, W., Gysens, F., Vromman, M., Goovaerts, T.
, Hansen, T. B., Kuersten, S., Nijs, N. ... Mestdagh, P. (2021).
The RNA Atlas expands the catalog of human non-coding RNAs.
Nature Biotechnology,
39(11), 1453-1465.
https://doi.org/10.1038/s41587-021-00936-1Stoll, L., Rodríguez-Trejo, A., Guay, C., Brozzi, F., Bayazit, M. B., Gattesco, S., Menoud, V., Sobel, J., Marques, A. C.
, Venø, M. T., Esguerra, J. L. S., Barghouth, M., Suleiman, M., Marselli, L.
, Kjems, J., Eliasson, L., Renström, E., Bouzakri, K., Pinget, M. ... Regazzi, R. (2020).
A circular RNA generated from an intron of the insulin gene controls insulin secretion.
Nature Communications,
11, Article 5611.
https://doi.org/10.1038/s41467-020-19381-wDas Mahapatra, K., Pasquali, L., Søndergaard, J. N., Lapins, J., Nemeth, I. B., Baltás, E., Kemény, L., Homey, B.
, Moldovan, L. I., Kjems, J., Kutter, C., Sonkoly, E.
, Kristensen, L. S. & Pivarcsi, A. (2020).
A comprehensive analysis of coding and non-coding transcriptomic changes in cutaneous squamous cell carcinoma.
Scientific Reports,
10, Article 3637.
https://doi.org/10.1038/s41598-020-59660-6Venø, M. T., Reschke, C. R., Morris, G., Connolly, N. M. C.
, Su, J., Yan, Y., Engel, T., Jimenez-Mateos, E. M., Harder, L. M., Pultz, D., Haunsberger, S. J., Pal, A., Heller, J. P., Campbell, A., Langa, E., Brennan, G. P., Conboy, K., Richardson, A., Norwood, B. A. ... Henshall, D. C. (2020).
A systems approach delivers a functional microRNA catalog and expanded targets for seizure suppression in temporal lobe epilepsy.
Proceedings of the National Academy of Sciences,
117(27), 15977-15988.
https://doi.org/10.1073/pnas.1919313117
Ramsay, E., Raviña, M., Sarkhel, S., Hehir, S., Cameron, N. R., Ilmarinen, T., Skottman, H.
, Kjems, J., Urtti, A., Ruponen, M.
& Subrizi, A. (2020).
Avoiding the pitfalls of siRNA delivery to the retinal pigment epithelium with physiologically relevant cell models.
Pharmaceutics,
12(7), Article 667.
https://doi.org/10.3390/pharmaceutics12070667Yoshimoto, R.
, Rahimi, K., Hansen, T. B., Kjems, J. & Mayeda, A. (2020).
Biosynthesis of Circular RNA ciRS-7/CDR1as Is Mediated by Mammalian-wide Interspersed Repeats.
iScience,
23(7), Article 101345.
https://doi.org/10.1016/j.isci.2020.101345Just, J., Yan, Y., Farup, J., Sieljacks, P., Sloth, M., Venø, M., Gu, T., de Paoli, F. V., Nyengaard, J. R., Bæk, R., Jørgensen, M. M.
, Kjems, J., Vissing, K. & Drasbek, K. R. (2020).
Blood flow-restricted resistance exercise alters the surface profile, miRNA cargo and functional impact of circulating extracellular vesicles.
Scientific Reports,
10(1), Article 5835.
https://doi.org/10.1038/s41598-020-62456-3
Kirkegaard, K., Yan, Y., Sørensen, B. S., Hardason, T., Hanson, C., Ingerslev, H. J.
, Knudsen, U. B., Kjems, J., Lundin, K. & Ahlström, A. (2020).
Comprehensive analysis of soluble RNAs in human embryo culture media and blastocoel fluid.
Journal of Assisted Reproduction and Genetics,
37(9), 2199–2209.
https://doi.org/10.1007/s10815-020-01891-7
Hait, A. S., Olagnier, D., Sancho-Shimizu, V.
, Skipper, K. A., Helleberg, M.
, Larsen, S. M., Bodda, C., Moldovan, L. I., Ren, F., Brinck Andersen, N-S., Thomsen, M. M., Freytag, M. R., Darmalinggam, S., Parkes, I., Kadekar, D. D.
, Rahbek, S. H., van der Horst, D., Kristensen, L. S., Eriksson, K.
... Mogensen, T. H. (2020).
Defects in LC3B2 and ATG4A underlie HSV2 meningitis and reveal a critical role for autophagy in antiviral defense in humans.
Science Immunology,
5(54), Article eabc2691.
https://doi.org/10.1126/sciimmunol.abc2691
