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Complement proteins in axial spondyloarthritis: associations with disease activity and TNFi treatment response in a multicentre RCT.
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Molecular mechanisms underlying thrombosis in systemic lupus erythematosus – A Systematic review.
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Pilot Study of Sodium-Glucose Cotransporter 2 Inhibitor Empagliflozin Shows Reduced Intrarenal Complement Activation in Patients With Diabetes and CKD.
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Clinical associations of complement-activating collectins, collectin-10, collectin-11 and mannose-binding lectin in preterm neonates.
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& Loft, A. G. (2024).
Complement Proteins L-Ficolin and M-Ficolin Are Increased in Patients With Axial Spondyloarthritis and Decrease After Tumor Necrosis Factor Inhibitor Treatment.
The Journal of Rheumatology,
51(1), 31-38.
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Development of an immunoassay for quantification of soluble human CD40L (CD154) in plasma and serum samples.
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Diagnostic and prognostic value of mannan-binding lectin associated protein (MAp19) for functionally relevant coronary artery disease.
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Effect of dapagliflozin on collectins and complement activation in plasma from patients with type 2 diabetes and albuminuria: Data from the DapKid cohort.
Immunobiology,
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Exploring complement biomarkers in suspected axial spondyloarthritis.
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Inter-α-trypsin inhibitor heavy chain 4 (ITIH4) as a compensatory protease inhibitor in hereditary angioedema.
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Trypanosoma brucei Invariant Surface Glycoprotein 75 Is an Immunoglobulin Fc Receptor Inhibiting Complement Activation and Antibody-Mediated Cellular Phagocytosis.
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Mannan-Binding Lectin Is Associated with Inflammation and Kidney Damage in a Mouse Model of Type 2 Diabetes.
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MASP-2 deficiency does not prevent the progression of diabetic kidney disease in a mouse model of type 1 diabetes.
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POS0429 THE COMPLEMENT SYSTEM AND RESPONSE TO TNF INHIBITION IN PATIENTS WITH RADIOGRAPHIC AXIAL SPONDYLOARTHRITIS. POST HOC ANALYSIS FROM CONSUL, A LONGITUDINAL MULTI-CENTER RCT COHORT OF R-AXSPA-PATIENTS WITH A HIGH RISK OF STRUCTURAL PROGRESSION INITIATING TREATMENT WITH TNF-INHIBITOR. Poster session presented at EULAR 2023, Milano, Italy.
Hymøller, K. M., Christiansen, S. H., Schlosser, A. G.
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Recognition of Staphylococcus aureus by the pattern recognition molecules langerin, mannan-binding lectin, and surfactant protein D: the influence of capsular polysaccharides and wall teichoic acid. Frontiers in Immunology,
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, Billing, A. M., Minakawa, A., McCown, P. J., Rose, M. P.
... Rinschen, M. M. (2023).
An integrated organoid omics map extends modeling potential of kidney disease.
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Antigen footprint governs activation of the B cell receptor.
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Bispecific Complement Engagers for Targeted Complement Activation.
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Correction: A potent complement factor C3-specific nanobody inhibiting multiple functions in the alternative pathway of human and murine complement (Journal of Biological Chemistry (2018) 293(17) (6269–6281), (S0021925820397313), (10.1074/jbc.RA117.001179)).
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Diagnostic and Prognostic Value of H-ficolin for Functionally Relevant Coronary Artery Disease.
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, Hansen, A. G. & Thiel, S. (2023).
Differentiating Between Activation via the Lectin or the Classical Complement Pathway in Patients with Systemic Lupus Erythematosus.
Clinical and Experimental Immunology,
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Inter-α-inhibitor heavy chain H4 and sepsis-related coagulation disturbances: Another link between innate immunity and coagulation.
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Restriction of C1-inhibitor activity in hereditary angioedema by dominant-negative effects of disease-associated SERPING1 gene variants.
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Trypanosoma brucei Invariant Surface gp65 Inhibits the Alternative Pathway of Complement by Accelerating C3b Degradation.
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A low level of naturally occurring antibodies associates with functional antibody deficiency.
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Complement proteins are elevated in patients with axSpA compared with relevant controls with low back pain and axSpA-features without axSpA.. Poster session presented at EULAR 2022, Copenhagen, Denmark.
Laursen, T. L., Bossen, L., Pihl, R., Troldborg, A., Sandahl, T. D., Hansen, A. G., Folserass, T., Vesterhus, M.
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Highly Increased Levels of Inter-α-inhibitor Heavy Chain 4 (ITIH4) in Autoimmune Cholestatic Liver Diseases.
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Low levels of the innate immune system proteins MASP-2 and MAp44 in patients with common variable immunodeficiency.
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Mannan-binding lectin serine protease-2 (MASP-2) in human kidney and its relevance for proteolytic activation of the epithelial sodium channel.
Scientific Reports,
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, Hasle, H., Albertsen, B. K., Herlin, T. & Nordic Study Group of Pediatric Rheumatology (NoSPeR) group (2022).
M-ficolin: a valuable biomarker to identify leukaemia from juvenile idiopathic arthritis.
Archives of Disease in Childhood,
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Novel homozygous CD46 variant with C-isoform expression affects C3b inactivation in atypical hemolytic uremic syndrome.
European Journal of Immunology,
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& Loft, A. G. (2022).
POS0059 Complement proteins are elevated in patients with axSpa compared with relevant controls of patients with low back pain and spa-features without axSpa.
Annals of the Rheumatic Diseases,
81(Suppl 1), 245-246.
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Potency measurements of the complement system facilitated by antibodies targeting the zymogen form of complement factor D (Adipsin).
Molecular immunology,
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Quantification of the pro-form of human complement component factor D (adipsin).
Journal of Immunological Methods,
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Structure-Guided Engineering of a Complement Component C3-Binding Nanobody Improves Specificity and Adds Cofactor Activity.
Frontiers in Immunology,
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Gregersen, E., Betzer, C., Kim, W. S.
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Alpha-synuclein activates the classical complement pathway and mediates complement-dependent cell toxicity.
Journal of Neuroinflammation,
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Juul-Madsen, K., Troldborg, A., Wittenborn, T. R., Axelsen, M. G., Zhao, H.
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, Sutherland, D. S., Degn, S. E. & Vorup-Jensen, T. (2021).
Characterization of DNA-protein complexes by nanoparticle tracking analysis and their association with systemic lupus erythematosus.
Proceedings of the National Academy of Sciences (PNAS),
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Hoffmann-Petersen, I. T., Holt, C. B., Jensen, L., Hage, C., Mellbin, L. G.
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Effect of dipeptidyl peptidase-4 inhibitors on complement activation.
Diabetes/Metabolism Research and Reviews,
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Boldt, A. B. W., Oliveira-Toré, C. D. F., Kretzschmar, G. C., Weinschutz Mendes, H., Stinghen, S. T., Andrade, F. A., Bumiller-Bini, V., Gonçalves, L. B., Braga, A. C. D. M., Stahlke, E. V. R. S., Velavan, T. P.
, Thiel, S. & de Messias-Reason, I. J. T. (2021).
Hepatitis B Virus Infection Among Leprosy Patients: A Case for Polymorphisms Compromising Activation of the Lectin Pathway and Complement Receptors.
Frontiers in Immunology,
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, Andersen, G. R., Enghild, J. J. & Thiel, S. (2021).
ITIH4 acts as a protease inhibitor by a novel inhibitory mechanism.
Science Advances,
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Gedebjerg, A., Thomsen, R. W., Kjaergaard, A. D., Steffensen, R., Nielsen, J. S.
, Rungby, J., Friborg, S. G., Brandslund, I.
, Thiel, S., Beck-Nielsen, H.
, Sørensen, H. T., Hansen, T. K. & Bjerre, M. (2021).
Mannose-binding lectin and risk of infections in type 2 diabetes: A Danish cohort study.
Journal of Diabetes and its Complications,
35(5), Article 107873.
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Brix, N. M., Glerup, M., Thiel, S., Elbæk Mistegård, C., Skals, R. G., Berntson, L., Fasth, A., Nielsen, S., Nordal, E., Rygg, M.
, Hasle, H., Albertsen, BK., Herlin, T. & on behalf of the Nordic Study Group of Pediatric Rheumatology (NoSPeR) (2021).
M-ficolin: a valuable biomarker to identify leukemia from juvenile idiopathic arthritis.
Pediatric Rheumatology ,
19(Suppl 1), 24-24. Article P6.
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Medjeral-Thomas, N. R.
, Troldborg, A., Hansen, A. G., Gisby, J., Clarke, C., Prendecki, M., McAdoo, S. P., Sandhu, E., Lightstone, L., Thomas, D. C., Willicombe, M., Botto, M., Peters, J. E., Pickering, M. C.
& Thiel, S. (2021).
Plasma Lectin Pathway Complement Proteins in Patients With COVID-19 and Renal Disease.
Frontiers in Immunology,
12, Article 671052.
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, Troldborg, A., Hansen, A. G., Pihl, R., Clarke, C. L., Peters, J. E.
, Thomas, D. C., Willicombe, M., Palarasah, Y., Botto, M., Pickering, M. C.
& Thiel, S. (2021).
Protease inhibitor plasma concentrations associate with COVID-19 infection.
Oxford open immunology,
2(1), Article iqab014.
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& Rinschen, M. M. (2021).
Proteolysis and inflammation of the kidney glomerulus.
Cell and Tissue Research,
385(2), 489-500.
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Bernth Jensen, J. M., Skeldal, S., Petersen, M. S., Møller, B. K., Hoffmann, S.
, Jensenius, J. C., Sørensen, U. B. S. & Thiel, S. (2021).
The human natural anti-αGal antibody targets common pathogens by broad-spectrum polyreactivity.
Immunology,
162(4), 434-451.
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Østergaard, J. A., Jansson Sigfrids, F., Forsblom, C., Dahlström, E. H., Thorn, L. M., Harjutsalo, V., Flyvbjerg, A.
, Thiel, S., Hansen, T. K. & Groop, P.-H. (2021).
The pattern-recognition molecule H-ficolin in relation to diabetic kidney disease, mortality, and cardiovascular events in type 1 diabetes.
Scientific Reports,
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Bernth Jensen, J. M., Petersen, M. S., Ellerman-Eriksen, S., Møller, B. K., Jensenius, J. C., Sørensen, U. B. S. & Thiel, S. (2020).
Abundant human anti-Galα3Gal antibodies display broad pathogen reactivity.
Scientific Reports,
10(1), Article 4611.
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