Steffen Thiel

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Pedersen, K., Green, K., Kristoffersen, E. L., Schinkel, T., Hansen, A. G., Palarasah, Y., Rovsing, A. B., Andersen, E. S., Valero, J., Civit, L., Laursen, N. S., Troldborg, A., Degn, S. E. & Thiel, S. (2026). Curbing Autoimmunity: A New Fab Fragment Targeting CD40-CD40L Halts B-Cell Activation and Differentiation. European Journal of Immunology, 56(2), Article e70158. https://doi.org/10.1002/eji.70158

Bernth Jensen, J. M., Søgaard, O. S., Petersen, M. S., Hoffmann, S., Møller, B. K., Hansen, A. G., Sørensen, U. B. S. & Thiel, S. (2026). Isohemagglutinins exhibit synergistic polyreactivity toward Streptococcus pneumoniae surface antigens: implications for broad-spectrum reactivity of human antibodies. Medical Microbiology and Immunology, 215(1), Article 5. https://doi.org/10.1007/s00430-025-00862-y

Jensen, M., Thiel, S., Hansen, S. W. K., Palarasah, Y., Svenningsen, P. & Jensen, B. L. (2026). SGLT-2 inhibitors attenuate pattern recognition molecules collectin kidney 1 and mannose-binding lectin in kidney and liver in mice with diabetes. American journal of physiology. Renal physiology, 330(1), F17-F31. https://doi.org/10.1152/ajprenal.00184.2025

Vinther, S. C., Resag, A., Le, K. T. T., Zelle-Rieser, C. C., Strandt, H., Malle, M. G., Christiansen, S. H., Del Frari, B., Stigger, T., Schilling, B., Wohlfarth, J., Thiel, S., Valero, J., Stoitzner, P. & Kjems, J. (2026). Targeting Langerhans cells using a modular mannosylated nucleic acid-based vaccine platform. Journal of Controlled Release, 392, 114741. Advance online publication. https://doi.org/10.1016/j.jconrel.2026.114741

Mistegaard, C., Troldborg, A., Torgutalp, M., Loft, A. G., Thiel, S., Muche, B., Rios Rodriguez, V., Protopopov, M., Listing, J., Sieper, J., Poddubnyy, D. & Proft, F. (2025). Complement proteins in axial spondyloarthritis: associations with disease activity and TNFi treatment response in a multicentre RCT. Rheumatology Advances in Practice, 9(1), Article rkaf007. https://doi.org/10.1093/rap/rkaf007

Mistegaard, C., Troldborg, A., Torgutalp, M., Loft, A. G., Thiel, S., Muche, B., Rios Rodriguez, V., Protopopov, M., Listing, J., Sieper, J., Poddubnyy, D. & Proft, F. (2025). Complement system activation is associated with spinal radiographic progression in axial spondyloarthritis after 2 years of follow-up: findings from the CONSUL RCT. RMD Open, 11(4), Article e006087. https://doi.org/10.1136/rmdopen-2025-006087

Hymøller, K. M., Crone, L., Thiel, S. & Hennet, T. (2025). Differential Recognition of Lipopolysaccharide O-Antigens by the Pattern Recognition Molecules Mannan-Binding Lectin and Ficolins of the Complement System. Journal of Innate Immunity, 17(1), 397–413. https://doi.org/10.1159/000547441

Bernth Jensen, J. M., Dinh, K. M., Hindhede, L., Erikstrup, L. T., Hansen, A. G., Hymøller, K. M., Ostrowski, S. R., Pedersen, O. B. V., Christiansen, S. H., Sørensen, U. B. S., Thiel, S. & Erikstrup, C. (2025). Impact of Staphylococcus aureus colonization and skin abscesses on formation of human anti-αGal antibodies. Medical Microbiology and Immunology, 214(1), Article 23. https://doi.org/10.1007/s00430-025-00833-3

Sagedal, S., Hovd, M., Åsberg, A., Mollnes, T. E., Klingenberg, O., Heldal, T. F., Witczak, B. J., Hejlesen, T. K., Troldborg, A. & Thiel, S. (2025). Increased levels of ficolin-1 and of C3dg are independently associated with high risk of infection in patients with chronic kidney disease: a prospective cohort study. Frontiers in Immunology, 16, Article 1645347. https://doi.org/10.3389/fimmu.2025.1645347

Larsen, M. L., Nørgaard, L., Linge, P., Larsen, J. B., Langkilde, H. Z., Hauge, E. M., Thiel, S., Voss, A., Bengtsson, A. & Troldborg, A. (2025). Molecular mechanisms underlying thrombosis in systemic lupus erythematosus: A Systematic review. Seminars in Arthritis and Rheumatism, 72, Article 152707. https://doi.org/10.1016/j.semarthrit.2025.152707

Jensen, E. G., Jakobsen, T. S., Schnabolk, G., Wilson, K., Rask-Pedersen, M., Jensen, N., Andersen, G. R., Thiel, S., Aagaard, L., Rohrer, B., Askou, A. L. & Corydon, T. J. (2025). Nanobody-based gene therapy targeting complement component C3 reduces choroidal neovascularization in mice. Molecular Therapy Methods and Clinical Development, 33(4), Article 101620. https://doi.org/10.1016/j.omtm.2025.101620

Jensen, M., Nielsen, S. F., Thiel, S., Hansen, S. W. K., Palarasah, Y., Svenningsen, P., Bech, J. N., Mose, F. H. & Jensen, B. L. (2025). Pilot Study of Sodium-Glucose Cotransporter 2 Inhibitor Empagliflozin Shows Reduced Intrarenal Complement Activation in Patients With Diabetes and CKD. Kidney International Reports, 10(2), 591-595. https://doi.org/10.1016/j.ekir.2024.11.014, https://doi.org/10.1016/j.ekir.2024.11.014

Demir, F., Kovalenko, E., Lassé, M., Svenningsen, E. B., Bernth Jensen, J. M., Billing, A. M., Groeneveld, K., Hutzfeldt, A., Nilges, L., Guerra, J. P. L., Pietrzak-Lichwa, K. J., Tan, Y., Colby, E., Hansen, A. G., Kurmasheva, N., Olagnier, D., Choi, D., Richter, M. M., Laufer, S. D. ... Rinschen, M. M. (2025). Proteolytic profiling of human plasma reveals an immunoactive complement C3 fragment. The EMBO Journal, 44(24), 7721-7758. https://doi.org/10.1038/s44318-025-00598-8

Pedersen, K., Hansen, A. G., Palarasah, Y., Troldborg, A. & Thiel, S. (2025). Treat-To-Target: Emergence of Second-Generation CD40L Inhibitors for Treatment of SLE-Identifying Beneficial Patient Candidates for CD40L Inhibitors in a Cross-Sectional SLE Cohort. Scandinavian Journal of Immunology, 102(3), Article e70050. https://doi.org/10.1111/sji.70050

Gajek, G., Hansen, S. W. K., Jarych, D., Kufelnicka-Babout, M., Świerzko, A. S., Kobiela, P., Szala-Poździej, A., Chojnacka, K., Sobczuk, K., Domżalska-Popadiuk, I., Mazela, J., Kalinka, J., Thiel, S. & Cedzyński, M. (2024). Clinical associations of complement-activating collectins, collectin-10, collectin-11 and mannose-binding lectin in preterm neonates. Frontiers in Immunology, 15, Article 1463651. https://doi.org/10.3389/fimmu.2024.1463651

Mistegaard, C. E., Troldborg, A., Hansen, A., Thiel, S., Jurik, A. G., Kiil, R. M., Christiansen, A. A., Schiøttz-Christensen, B., Hendricks, O., Pedersen, S. J., Sørensen, I. J., Østergaard, M. & Loft, A. G. (2024). Complement Proteins L-Ficolin and M-Ficolin Are Increased in Patients With Axial Spondyloarthritis and Decrease After Tumor Necrosis Factor Inhibitor Treatment. The Journal of Rheumatology, 51(1), 31-38. https://doi.org/10.3899/jrheum.2023-0164

Pedersen, K., Laursen, N. S., Hansen, A. G., Palarasah, Y. & Thiel, S. (2024). Development of an immunoassay for quantification of soluble human CD40L (CD154) in plasma and serum samples. Journal of Immunological Methods, 531, Article 113710. https://doi.org/10.1016/j.jim.2024.113710

Isayeva, G., Rumora, K., Potlukova, E., Leibfarth, J.-P., Schäfer, I., Bartha, Z., Zellweger, M. J., Trendelenburg, M., Hejlesen, T. K., Hansen, A. G., Thiel, S. & Mueller, C. (2024). Diagnostic and prognostic value of mannan-binding lectin associated protein (MAp19) for functionally relevant coronary artery disease. Clinica Chimica Acta, 558, Article 119668. https://doi.org/10.1016/j.cca.2024.119668

Jensen, M., Eickhoff, M. K., Persson, F., Rossing, P., Thiel, S., Hansen, S. W. K., Palarasah, Y., Svenningsen, P. & Jensen, B. L. (2024). Effect of dapagliflozin on collectins and complement activation in plasma from patients with type 2 diabetes and albuminuria: Data from the DapKid cohort. Immunobiology, 229(3), 152797. Article 152797. https://doi.org/10.1016/j.imbio.2024.152797

Mistegård, C. E., Troldborg, A., Loft, A. G., Thiel, S., Spiller, L., Protopopov, M., Rios Rodriguez, V., Muche, B., Rademacher, J., Weber, A. K., Lüders, S., Sieper, J., Poddubnyy, D. & Proft, F. (2024). Exploring complement biomarkers in suspected axial spondyloarthritis. RMD Open, 10(2), Article e004127. https://doi.org/10.1136/rmdopen-2024-004127

Troldborg, A., Godnic-Polai, Z., Cervenak, L., Hansen, A. G., Farkas, H. & Thiel, S. (2024). Inter-α-trypsin inhibitor heavy chain 4 (ITIH4) as a compensatory protease inhibitor in hereditary angioedema. The Journal of Allergy and Clinical Immunology, 154(2), 468-479.e6. https://doi.org/10.1016/j.jaci.2024.03.028

Mikkelsen, J. H., Stødkilde, K., Jensen, M. P., Hansen, A. G., Wu, Q., Lorentzen, J., Graversen, J. H., Andersen, G. R., Fenton, R. A., Etzerodt, A., Thiel, S. & Andersen, C. B. F. (2024). Trypanosoma brucei Invariant Surface Glycoprotein 75 Is an Immunoglobulin Fc Receptor Inhibiting Complement Activation and Antibody-Mediated Cellular Phagocytosis. Journal of Immunology, 212(8), 1334-1344. https://doi.org/10.4049/jimmunol.2300862

Dørflinger, G. H., Holt, C. B., Thiel, S., Bech, J. N., Østergaard, J. A. & Bjerre, M. (2024). Mannan-Binding Lectin Is Associated with Inflammation and Kidney Damage in a Mouse Model of Type 2 Diabetes. International Journal of Molecular Sciences , 25(13), Article 7204. https://doi.org/10.3390/ijms25137204

Holt, C. B., Halkjær, L., Dudley, T., Schwaeble, W., Krarup Hansen, T., Thiel, S. & Østergaard, J. A. (2024). MASP-2 deficiency does not prevent the progression of diabetic kidney disease in a mouse model of type 1 diabetes. Scandinavian Journal of Immunology, 99(4), Article e13348. https://doi.org/10.1111/sji.13348

Elbæk Mistegård, C., Troldborg, A., Loft, A. G. R., Thiel, S., Muche, B., Rios Rodriguez, V., Torgutalp, M., Protopopov, M., Listing, J., Sieper, J., Poddubnyy, D. & Proft, F. (2024). POS0429 THE COMPLEMENT SYSTEM AND RESPONSE TO TNF INHIBITION IN PATIENTS WITH RADIOGRAPHIC AXIAL SPONDYLOARTHRITIS. POST HOC ANALYSIS FROM CONSUL, A LONGITUDINAL MULTI-CENTER RCT COHORT OF R-AXSPA-PATIENTS WITH A HIGH RISK OF STRUCTURAL PROGRESSION INITIATING TREATMENT WITH TNF-INHIBITOR. Poster session presented at EULAR 2023, Milano, Italy.

Hymøller, K. M., Christiansen, S. H., Schlosser, A. G., Skov Sørensen, U. B., Lee, J. C. & Thiel, S. (2024). Recognition of Staphylococcus aureus by the pattern recognition molecules langerin, mannan-binding lectin, and surfactant protein D: the influence of capsular polysaccharides and wall teichoic acid. Frontiers in Immunology, 15, Article 1504886. https://doi.org/10.3389/fimmu.2024.1504886

Lassé, M., El Saghir, J., Berthier, C. C., Eddy, S., Fischer, M., Laufer, S. D., Kylies, D., Hutzfeldt, A., Bonin, L. L., Dumoulin, B., Menon, R., Vega-Warner, V., Eichinger, F., Alakwaa, F., Fermin, D., Billing, A. M., Minakawa, A., McCown, P. J., Rose, M. P. ... Rinschen, M. M. (2023). An integrated organoid omics map extends modeling potential of kidney disease. Nature Communications, 14(1), Article 4903. https://doi.org/10.1038/s41467-023-39740-7