Lassé, M., El Saghir, J., Berthier, C. C., Eddy, S., Fischer, M., Laufer, S. D., Kylies, D., Hutzfeldt, A., Bonin, L. L., Dumoulin, B., Menon, R., Vega-Warner, V., Eichinger, F., Alakwaa, F., Fermin, D., Billing, A. M., Minakawa, A., McCown, P. J., Rose, M. P. ... Rinschen, M. M. (2023). An integrated organoid omics map extends modeling potential of kidney disease. Nature Communications, 14(1), Article 4903. https://doi.org/10.1038/s41467-023-39740-7

Ferapontov, A., Omer, M., Baudrexel, I., Nielsen, J. S., Dupont, D. M., Juul-Madsen, K., Steen, P., Eklund, A. S., Thiel, S., Vorup-Jensen, T., Jungmann, R., Kjems, J. & Degn, S. E. (2023). Antigen footprint governs activation of the B cell receptor. Nature Communications, 14(1), Article 976. https://doi.org/10.1038/s41467-023-36672-0

Pedersen, D. V., Gytz, H., Winkler, M. B. L., Zarantonello, A., Baumann, N., Hansen, A. G., Thiel, S., Andersen, G. R., Valerius, T. & Laursen, N. S. (2023). Bispecific Complement Engagers for Targeted Complement Activation. Journal of Immunology, 211(3), 403-413. Advance online publication. https://doi.org/10.4049/jimmunol.2200952

Jensen, R. K., Pihl, R., Gadeberg, T. A. F., Jensen, J. K., Andersen, K. R., Thiel, S., Laursen, N. S. & Andersen, G. R. (2023). Correction: A potent complement factor C3-specific nanobody inhibiting multiple functions in the alternative pathway of human and murine complement. The Journal of Biological Chemistry, 299(2), 102951. Advance online publication. https://doi.org/10.1016/j.jbc.2023.102951

Larsen, M. L., Troldborg, A., Toonen, E. J. M., Hurler, L., Prohaszka, Z., Cervenak, L., Hansen, A. G. & Thiel, S. (2023). Differentiating Between Activation via the Lectin or the Classical Complement Pathway in Patients with Systemic Lupus Erythematosus. Clinical and Experimental Immunology. Advance online publication. https://doi.org/10.1093/cei/uxad070

Larsen, J. B., Pihl, R., Aggerbeck, M. A., Larsen, K. M., Hvas, C. L., Johnsen, N., Christensen, M. G., Praetorius, H., Hvas, A-M. & Thiel, S. (2023). Inter-α-inhibitor heavy chain H4 and sepsis-related coagulation disturbances: Another link between innate immunity and coagulation. Research and Practice in Thrombosis and Haemostasis, 7(2), Article 100078. https://doi.org/10.1016/j.rpth.2023.100078

Vils, S. R., Troldborg, A., Hvas, A-M. & Thiel, S. (2023). Platelets and the Lectin Pathway of Complement Activation in Patients with Systemic Lupus Erythematosus or Antiphospholipid Syndrome. TH open : companion journal to thrombosis and haemostasis, 7(2), e155-e167. https://doi.org/10.1055/a-2087-0314

Ryo, L. B., Haslund, D., Rovsing, A. B., Pihl, R., Sanrattana, W., de Maat, S., Palarasah, Y., Maas, C., Thiel, S. & Mikkelsen, J. G. (2023). Restriction of C1-inhibitor activity in hereditary angioedema by dominant-negative effects of disease-associated SERPING1 gene variants. The Journal of allergy and clinical immunology. Advance online publication. https://doi.org/10.1016/j.jaci.2023.04.023

Lorentzen, J., Olesen, H. G., Hansen, A. G., Thiel, S., Birkelund, S., Andersen, C. B. F. & Andersen, G. R. (2023). Trypanosoma brucei Invariant Surface gp65 Inhibits the Alternative Pathway of Complement by Accelerating C3b Degradation. Journal of Immunology, 211(5), 862-873. Advance online publication. https://doi.org/10.4049/jimmunol.2300128

Bernth Jensen, J. M., Hansen, A. T., Söderström, A., Jørgensen, C. S., Larsen, C. S., Skov Sørensen, U. B., Thiel, S. & Petersen, M. S. (2022). A low level of naturally occurring antibodies associates with functional antibody deficiency. Clinical Immunology, 241, Article 109070. https://doi.org/10.1016/j.clim.2022.109070

Laursen, T. L., Bossen, L., Pihl, R., Troldborg, A., Sandahl, T. D., Hansen, A. G., Folserass, T., Vesterhus, M., Gronbaek, H. & Thiel, S. (2022). Highly Increased Levels of Inter-α-inhibitor Heavy Chain 4 (ITIH4) in Autoimmune Cholestatic Liver Diseases. Journal of clinical and translational hepatology, 10(5), 796–802. https://doi.org/10.14218/JCTH.2021.00515

Elbæk Mistegård, C., Jensen, L., Christiansen, M., Bjerre, M., Jensen, J. M. B. & Thiel, S. (2022). Low levels of the innate immune system proteins MASP-2 and MAp44 in patients with common variable immunodeficiency. Scand. J. Immunol., 96(3), Article e13196. https://doi.org/10.1111/sji.13196

Zachar, R., Thiel, S., Hansen, S., Henriksen, M. L., Skjoedt, M. O., Skjodt, K., Hamzaei, Z., Madsen, K., Lund, L., Hummler, E., Svenningsen, P. & Jensen, B. L. (2022). Mannan-binding lectin serine protease-2 (MASP-2) in human kidney and its relevance for proteolytic activation of the epithelial sodium channel. Scientific Reports, 12(1), Article 15955. https://doi.org/10.1038/s41598-022-20213-8

Brix, N., Glerup, M., Thiel, S., Mistegaard, C. E., Skals, R. G., Berntson, L., Fasth, A., Nielsen, S. M., Nordal, E., Rygg, M., Hasle, H., Albertsen, B. K., Herlin, T. & Nordic Study Group of Pediatric Rheumatology (NoSPeR) group (2022). M-ficolin: a valuable biomarker to identify leukaemia from juvenile idiopathic arthritis. Archives of Disease in Childhood, 107(4), 371-376. Article archdischild-2021-322114. Advance online publication. https://doi.org/10.1136/archdischild-2021-322114

Schack, V. R., Herlin, M. K., Pedersen, H., Jensen, J. M. B., Faerch, M., Bundgaard, B., Jensen, R. K., Jensen, U. B., Christensen, R., Andersen, G. R., Thiel, S. & Höllsberg, P. (2022). Novel homozygous CD46 variant with C-isoform expression affects C3b inactivation in atypical hemolytic uremic syndrome. European Journal of Immunology, 52(10), 1610-1619. Advance online publication. https://doi.org/10.1002/eji.202249838

Jørgensen, C. M., Troldborg, A., Hansen, A. G., Thiel, S., Jurik, A. G., Kiil, R. M., Christiansen, A. A., Schiøttz-Christensen, B., Hendricks, O. & Loft, A. G. (2022). POS0059 Complement proteins are elevated in patients with axSpa compared with relevant controls of patients with low back pain and spa-features without axSpa. Annals of the Rheumatic Diseases, 81(Suppl 1), 245-246. https://doi.org/10.1136/annrheumdis-2022-eular.3846

Palarasah, Y., Henriksen, A. S. L., Thiel, S., Henriksen, M. & Hansen, S. W. K. (2022). Potency measurements of the complement system facilitated by antibodies targeting the zymogen form of complement factor D (Adipsin). Molecular immunology, 146, 46-49. https://doi.org/10.1016/j.molimm.2022.04.002

Henriksen, M. L., Nielsen, C., Pedersen, D., Andersen, G. R., Thiel, S., Palarasah, Y. & Hansen, S. W. K. (2022). Quantification of the pro-form of human complement component factor D (adipsin). Journal of Immunological Methods, 507, 113295. Article 113295. Advance online publication. https://doi.org/10.1016/j.jim.2022.113295

Pedersen, H., Jensen, R. K., Hansen, A. G., Petersen, S. V., Thiel, S., Laursen, N. S. & Andersen, G. R. (2022). Structure-Guided Engineering of a Complement Component C3-Binding Nanobody Improves Specificity and Adds Cofactor Activity. Frontiers in Immunology, 13, Article 872536. https://doi.org/10.3389/fimmu.2022.872536

Gregersen, E., Betzer, C., Kim, W. S., Kovacs, G., Reimer, L., Halliday, G. M., Thiel, S. & Jensen, P. H. (2021). Alpha-synuclein activates the classical complement pathway and mediates complement-dependent cell toxicity. Journal of Neuroinflammation, 18(1), Article 177. https://doi.org/10.1186/s12974-021-02225-9

Juul-Madsen, K., Troldborg, A., Wittenborn, T. R., Axelsen, M. G., Zhao, H., Klausen, L. H., Luecke, S., Paludan, S. R., Stengaard-Pedersen, K., Dong, M., Møller, H. J., Thiel, S., Jensen, H., Schuck, P., Sutherland, D. S., Degn, S. E. & Vorup-Jensen, T. (2021). Characterization of DNA-protein complexes by nanoparticle tracking analysis and their association with systemic lupus erythematosus. Proceedings of the National Academy of Sciences, 118(30), Article e2106647118. https://doi.org/10.1073/pnas.2106647118

Hoffmann-Petersen, I. T., Holt, C. B., Jensen, L., Hage, C., Mellbin, L. G., Thiel, S., Hansen, T. K. & Østergaard, J. A. (2021). Effect of dipeptidyl peptidase-4 inhibitors on complement activation. Diabetes/Metabolism Research and Reviews, 37(3), Article e3385. Advance online publication. https://doi.org/10.1002/dmrr.3385

Boldt, A. B. W., Oliveira-Toré, C. D. F., Kretzschmar, G. C., Weinschutz Mendes, H., Stinghen, S. T., Andrade, F. A., Bumiller-Bini, V., Gonçalves, L. B., Braga, A. C. D. M., Stahlke, E. V. R. S., Velavan, T. P., Thiel, S. & de Messias-Reason, I. J. T. (2021). Hepatitis B Virus Infection Among Leprosy Patients: A Case for Polymorphisms Compromising Activation of the Lectin Pathway and Complement Receptors. Frontiers in Immunology, 11, Article 574457. https://doi.org/10.3389/fimmu.2020.574457

Pihl, R., Jensen, R. K., Poulsen, E. C., Jensen, L., Hansen, A. G., Thøgersen, I. B., Dobó, J., Gál, P., Andersen, G. R., Enghild, J. J. & Thiel, S. (2021). ITIH4 acts as a protease inhibitor by a novel inhibitory mechanism. Science Advances, 7(2), Article 7381. https://doi.org/10.1126/sciadv.aba7381

Gedebjerg, A., Thomsen, R. W., Kjaergaard, A. D., Steffensen, R., Nielsen, J. S., Rungby, J., Friborg, S. G., Brandslund, I., Thiel, S., Beck-Nielsen, H., Sørensen, H. T., Hansen, T. K. & Bjerre, M. (2021). Mannose-binding lectin and risk of infections in type 2 diabetes: A Danish cohort study. Journal of Diabetes and its Complications, 35(5), Article 107873. https://doi.org/10.1016/j.jdiacomp.2021.107873

Brix, N. M., Glerup, M., Thiel, S., Elbæk Mistegård, C., Skals, R. G., Berntson, L., Fasth, A., Nielsen, S., Nordal, E., Rygg, M., Hasle, H., Albertsen, BK., Herlin, T. & on behalf of the Nordic Study Group of Pediatric Rheumatology (NoSPeR) (2021). M-ficolin: a valuable biomarker to identify leukemia from juvenile idiopathic arthritis. Pediatric Rheumatology , 19(Suppl 1), 24-24. Article P6. https://doi.org/10.1186/s12969-021-00632-z

Medjeral-Thomas, N. R., Troldborg, A., Hansen, A. G., Gisby, J., Clarke, C., Prendecki, M., McAdoo, S. P., Sandhu, E., Lightstone, L., Thomas, D. C., Willicombe, M., Botto, M., Peters, J. E., Pickering, M. C. & Thiel, S. (2021). Plasma Lectin Pathway Complement Proteins in Patients With COVID-19 and Renal Disease. Frontiers in Immunology, 12, Article 671052. https://doi.org/10.3389/fimmu.2021.671052

Medjeral-Thomas, N. R., Troldborg, A., Hansen, A. G., Pihl, R., Clarke, C. L., Peters, J. E., Thomas, D. C., Willicombe, M., Palarasah, Y., Botto, M., Pickering, M. C. & Thiel, S. (2021). Protease inhibitor plasma concentrations associate with COVID-19 infection. Oxford open immunology, 2(1), Article iqab014. https://doi.org/10.1093/oxfimm/iqab014

Demir, F., Troldborg, A., Thiel, S., Lassé, M., Huesgen, P. F., Tomas, N. M., Wiech, T. & Rinschen, M. M. (2021). Proteolysis and inflammation of the kidney glomerulus. Cell and Tissue Research, 385(2), 489-500. Advance online publication. https://doi.org/10.1007/s00441-021-03433-8

Bernth Jensen, J. M., Skeldal, S., Petersen, M. S., Møller, B. K., Hoffmann, S., Jensenius, J. C., Sørensen, U. B. S. & Thiel, S. (2021). The human natural anti-αGal antibody targets common pathogens by broad-spectrum polyreactivity. Immunology, 162(4), 434-451. https://doi.org/10.1111/imm.13297

Bernth Jensen, J. M., Søgaard, O. S. & Thiel, S. (2021). The level of naturally occurring anti-αGal antibody predicts antibody response to polysaccharide vaccination in HIV-infected adults. Scandinavian Journal of Immunology, 93(5), Article e13008. https://doi.org/10.1111/sji.13008

Østergaard, J. A., Jansson Sigfrids, F., Forsblom, C., Dahlström, E. H., Thorn, L. M., Harjutsalo, V., Flyvbjerg, A., Thiel, S., Hansen, T. K. & Groop, P-H. (2021). The pattern-recognition molecule H-ficolin in relation to diabetic kidney disease, mortality, and cardiovascular events in type 1 diabetes. Scientific Reports, 11(1), 8919. Article 8919. https://doi.org/10.1038/s41598-021-88352-y

Bernth Jensen, J. M., Petersen, M. S., Ellerman-Eriksen, S., Møller, B. K., Jensenius, J. C., Sørensen, U. B. S. & Thiel, S. (2020). Abundant human anti-Galα3Gal antibodies display broad pathogen reactivity. Scientific Reports, 10(1), Article 4611. https://doi.org/10.1038/s41598-020-61632-9

Pedersen, H., Jensen, R. K., Hansen, A. G., Gadeberg, T. A. F., Thiel, S., Laursen, N. S. & Andersen, G. (2020). A C3 specific nanobody that blocks all three activation pathways in the human and murine complement system. The Journal of Biological Chemistry, 295(26), 8746-8758. Advance online publication. https://doi.org/10.1074/jbc.RA119.012339

Pedersen, H., Jensen, R. K., Jensen, J. M. B., Fox, R., Pedersen, D. V., Olesen, H. G., Hansen, A. G., Christiansen, D., Mazarakis, S. M. M., Lojek, N., Hansen, P., Gadeberg, T. A. F., Zarantonello, A., Laursen, N. S., Mollnes, T. E., Johnson, M. B., Stevens, B., Thiel, S. & Andersen, G. R. (2020). A Complement C3-Specific Nanobody for Modulation of the Alternative Cascade Identifies the C-Terminal Domain of C3b as Functional in C5 Convertase Activity. Journal of Immunology, 205(8), 2287-2300. Advance online publication. https://doi.org/10.4049/jimmunol.2000752

Weinschutz Mendes, H., Boldt, A. W., Stahlke, E., Jensenius, J. C., Thiel, S. & Messias-Reason, I. J. T. (2020). Adding MASP1 to the lectin pathway-Leprosy association puzzle: Hints from gene polymorphisms and protein levels. PLOS Neglected Tropical Diseases , 14(4), 1-20. Article e0007534. https://doi.org/10.1371/journal.pntd.0007534

Zarantonello, A., Presumey, J., Simoni, L., Yalcin, E., Fox, R., Hansen, A., Olesen, H. G., Thiel, S., Johnson, M. B., Stevens, B., Laursen, N. S., Carroll, M. C. & Andersen, G. R. (2020). An Ultrahigh-Affinity Complement C4b-Specific Nanobody Inhibits In Vivo Assembly of the Classical Pathway Proconvertase. Journal of Immunology, 205(6), 1678-1694. Advance online publication. https://doi.org/10.4049/jimmunol.2000528

Holt, C. B., Hoffmann-Petersen, I. T., Hansen, T. K., Parving, H-H., Thiel, S., Hovind, P., Tarnow, L., Rossing, P. & Østergaard, J. A. (2020). Association between severe diabetic retinopathy and lectin pathway proteins - an 18-year follow-up study with newly diagnosed type 1 diabetes patients. Immunobiology, 225(3), Article 151939. Advance online publication. https://doi.org/10.1016/j.imbio.2020.151939

Jensen, E. G., Jakobsen, T. S., Thiel, S., Askou, A. L. & Corydon, T. J. (2020). Associations between the Complement System and Choroidal Neovascularization in Wet Age-Related Macular Degeneration. International Journal of Molecular Sciences , 21(24), Article 9752. https://doi.org/10.3390/ijms21249752

Sokołowska, A., Świerzko, A. S., Gajek, G., Gołos, A., Michalski, M., Nowicki, M., Szala-Poździej, A., Wolska-Washer, A., Brzezińska, O., Wierzbowska, A., Jamroziak, K., Kowalski, M. L., Thiel, S., Matsushita, M., Jensenius, J. C. & Cedzyński, M. (2020). Associations of ficolins and mannose-binding lectin with acute myeloid leukaemia in adults. Scientific Reports, 10(1), Article 10561. https://doi.org/10.1038/s41598-020-67516-2

Świerzko, A. S., Michalski, M., Sokołowska, A., Nowicki, M., Szala-Poździej, A., Eppa, Ł., Mitrus, I., Szmigielska-Kapłon, A., Sobczyk-Kruszelnicka, M., Michalak, K., Gołos, A., Wierzbowska, A., Giebel, S., Jamroziak, K., Kowalski, M. L., Brzezińska, O., Thiel, S., Matsushita, M., Jensenius, J. C. ... Cedzyński, M. (2020). Associations of Ficolins With Hematological Malignancies in Patients Receiving High-Dose Chemotherapy and Autologous Hematopoietic Stem Cell Transplantations. Frontiers in Immunology, 10, Article 3097. https://doi.org/10.3389/fimmu.2019.03097

LaFon, D. C., Thiel, S., Kim, Y-I., Dransfield, M. T. & Nahm, M. H. (2020). Classical and lectin complement pathways and markers of inflammation for investigation of susceptibility to infections among healthy older adults. Immunity & ageing : I & A, 17(1), Article 18. https://doi.org/10.1186/s12979-020-00189-7

Bernth Jensen, J. M., Laursen, N. S., Kjeldsen Jensen, R., Andersen, G. R., Jensenius, J. C., Skov Sørensen, U. B. & Thiel, S. (2020). Complement activation by human IgG antibodies to galactose-α-1,3-galactose. Immunology, 161(1), 66-79. Advance online publication. https://doi.org/10.1111/imm.13229

Troldborg, A., Halkjær, L., Pedersen, H., Hansen, A., Loft, A. G., Lindegaard, H., Stengaard-Pedersen, K., Graversen, J. H., Palarasah, Y. & Thiel, S. (2020). Complement activation in human autoimmune diseases and mouse models; employing a sandwich immunoassay specific for C3dg. Journal of Immunological Methods, 486, Article 112866. https://doi.org/10.1016/j.jim.2020.112866

Halkjær, L., Troldborg, A., Pedersen, H., Jensen, L., Hansen, A. G., Krarup Hansen, T., Bjerre, M., Østergaard, J. A. & Thiel, S. (2020). Complement Receptor 2 Based Immunoassay Measuring Activation of the Complement System at C3-level in Plasma Samples from Mice and Humans. Frontiers in Immunology, 11, Article 774. https://doi.org/10.3389/fimmu.2020.00774

Laursen, N. S., Pedersen, D. V., Gytz, H., Zarantonello, A., Bernth Jensen, J. M., Hansen, A. G., Thiel, S. & Andersen, G. R. (2020). Functional and Structural Characterization of a Potent C1q Inhibitor Targeting the Classical Pathway of the Complement System. Frontiers in Immunology, 11, Article 1504. https://doi.org/10.3389/fimmu.2020.01504

Holers, V. M., Borodovsky, A., Scheinman, R. I., Ho, N., Ramirez, J. R., Dobó, J., Gál, P., Lindenberger, J., Hansen, A. G., Desai, D., Pihl, R., Thiel, S. & Banda, N. K. (2020). Key Components of the Complement Lectin Pathway Are Not Only Required for the Development of Inflammatory Arthritis but Also Regulate the Transcription of Factor D. Frontiers in Immunology, 11, Article 201. https://doi.org/10.3389/fimmu.2020.00201

Gedebjerg, A., Bjerre, M., Kjaergaard, A. D., Steffensen, R., Nielsen, J. S., Rungby, J., Friborg, S. G., Brandslund, I., Thiel, S., Beck-Nielsen, H., Sørensen, H. T., Hansen, T. K. & Thomsen, R. W. (2020). Mannose-Binding Lectin and Risk of Cardiovascular Events and Mortality in Type 2 Diabetes: A Danish Cohort Study. Diabetes Care, 43(9), 2190-2198. Advance online publication. https://doi.org/10.2337/dc20-0345

Troldborg, A., Thiel, S., Elbaek, C. M., Hansen, A., Korsholm, T-L., Stengaard-Pedersen, K. & Loft, A. G. (2020). Plasma levels of H- and L-ficolin are increased in axial spondyloarthritis: Improvement of disease identification. Clinical and Experimental Immunology, 199(1), 79-87. Advance online publication. https://doi.org/10.1111/cei.13374