Ommen, P., Hansen, L., Hansen, B. K., Vu-Quang, H., Kjems, J. & Meyer, R. L. (2022).
Aptamer-Targeted Drug Delivery for Staphylococcus aureus Biofilm.
Frontiers in cellular and infection microbiology,
12, Article 814340.
https://doi.org/10.3389/fcimb.2022.814340
Staulund, J.
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, Keller, A. K., Nørregaard, R., Pedersen, M., Leuvenink, H.
, Kjems, J., Jespersen, B. & Eijken, M. (2022).
Assessing the quality of donor kidneys during normothermic machine perfusion using nanoparticle-based vitality sensors. Abstract from 3rd ECTORS meeting, Rotterdam, Netherlands.
Nielsen, A. F., Bindereif, A., Bozzoni, I., Hanan, M.
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, Kristensen, L. S., Legnini, I., Morlando, M.
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& Kjems, J. (2022).
Best practice standards for circular RNA research.
Nature Methods,
19(10), 1208-1220.
https://doi.org/10.1038/s41592-022-01487-2
Catapano, C., Rahm, J. V.
, Omer, M., Teodori, L., Kjems, J., Dietz, M. S. & Heilemann, M. (2022).
Biased activation of the receptor tyrosine kinase HER2. bioRxiv.
https://doi.org/10.1101/2022.12.04.519064Fjelstrup, S., Dupont, D. M., Bus, C., Enghild, J. J., Jensen, J. B., Birkenkamp-Demtröder, K., Dyrskjøt, L. & Kjems, J. (2022).
Differential RNA aptamer affinity profiling on plasma as a potential diagnostic tool for bladder cancer.
NAR cancer,
4(3), Article zcac025.
https://doi.org/10.1093/narcan/zcac025
Gomes-Duarte, A.
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, Kjems, J., Vangoor, V. R. & Pasterkamp, R. J. (2022).
Expression of Circ_Satb1 Is Decreased in Mesial Temporal Lobe Epilepsy and Regulates Dendritic Spine Morphology.
Frontiers in Molecular Neuroscience,
15, Article 832133.
https://doi.org/10.3389/fnmol.2022.832133Dahl, M., Husby, S., Eskelund, C. W.
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Expression patterns and prognostic potential of circular RNAs in mantle cell lymphoma: a study of younger patients from the MCL2 and MCL3 clinical trials.
Leukemia,
36(1), 177-188.
https://doi.org/10.1038/s41375-021-01311-4Østergaard, R. H., Yan, Y., Venø, M. T.
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& Hayashi, Y. (2022).
Extracellular Vesicle Biology Meets Zebrafish: Real-Time Visualization and RNA Profiling of Physiological Exosomes in the Bloodstream. Poster session presented at The Danish Society for Extracellular Vesicles (DSEV) 3rd Annual Symposium 2022, Roskilde, Denmark.
Song, P., Staulund, J., Qi, H.
, Thrane, L., Pedersen, M., Eijken, M., Jespersen, B. & Kjems, J. (2022).
Ex-vivo mRNA therapy to predict kidney vitality during transplantation. Poster session presented at Danish RNA Society's 7th Annual Meeting, Aarhus, Denmark.
Märcher, A., Kumar, V., Andersen, V. L., El-Chami, K., Nguyen, T. J. D., Skaanning, M. K., Rudnik-Jansen, I., Nielsen, J. S., Howard, K. A., Kjems, J. & Gothelf, K. V. (2022).
Functionalized Acyclic (l)-Threoninol Nucleic Acid Four-Way Junction with High Stability In Vitro and In Vivo.
Angewandte Chemie - International Edition,
61(24), Article 202115275.
https://doi.org/10.1002/anie.202115275
Seeler, S., Moldovan, L.-I., Bertelsen, T., Hager, H., Iversen, L., Johansen, C., Kjems, J. & Sommer Kristensen, L. (2022).
Global circRNA expression changes predate clinical and histological improvements of psoriasis patients upon secukinumab treatment.
PLoS One,
17(9), Article e0275219.
https://doi.org/10.1371/journal.pone.0275219
Teodori, L., Omer, M., Märcher, A., Skaanning, M. K., Andersen, V. L., Nielsen, J. S., Oldenburg, E., Lin, Y., Gothelf, K. V. & Kjems, J. (2022).
Site-specific nanobody-oligonucleotide conjugation for super-resolution imaging.
Journal of Biological Methods,
9(1), Article e159.
https://doi.org/10.14440/jbm.2022.381
Khateb, H., Sørensen, R. S., Cramer, K., Eklund, A. S.
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The Role of Nanoscale Distribution of Fibronectin in the Adhesion of Staphylococcus aureus Studied by Protein Patterning and DNA-PAINT.
ACS Nano,
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https://doi.org/10.1021/acsnano.2c00630
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The Role of Plasma Extracellular Vesicles in Remote Ischemic Conditioning and Exercise-Induced Ischemic Tolerance.
International Journal of Molecular Sciences ,
23(6), Article 3334.
https://doi.org/10.3390/ijms23063334
Hansen, E. K. B., Fredsøe, J. H., Okholm, T. L. H., Ulhøi, B. P., Klingenberg, S., Jensen, J. B., Kjems, J., Bouchelouche, K., Borre, M., Damgaard, C. K., Pedersen, J. S., Kristensen, L. S. & Sørensen, K. D. (2022).
The transcriptional landscape and biomarker potential of circular RNAs in prostate cancer.
Genome Medicine,
14(1), Article 8.
https://doi.org/10.1186/s13073-021-01009-3
Vogt, S., Bobbili, M. R., Stadlmayr, G., Stadlbauer, K.
, Kjems, J., Rüker, F., Grillari, J. & Wozniak-Knopp, G. (2021).
An engineered CD81-based combinatorial library for selecting recombinant binders to cell surface proteins: Laminin binding CD81 enhances cellular uptake of extracellular vesicles.
Journal of Extracellular Vesicles,
10(11), Article e12139.
https://doi.org/10.1002/jev2.12139Valero, J., Civit, L., Dupont, D. M., Selnihhin, D., Reinert, L. S., Idorn, M., Israels, B. A., Bednarz, A. M., Bus, C., Asbach, B., Peterhoff, D.
, Pedersen, F. S., Birkedal, V., Wagner, R.
, Paludan, S. R. & Kjems, J. (2021).
A serum-stable RNA aptamer specific for SARS-CoV-2 neutralizes viral entry.
Proceedings of the National Academy of Sciences (PNAS),
118(50), Article e2112942118.
https://doi.org/10.1073/pnas.2112942118
Lassen, T. R., Just, J., Hjortbak, M. V., Jespersen, N. R., Stenz, K. T., Gu, T., Yan, Y., Su, J., Hansen, J., Bæk, R., Jørgensen, M. M.
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Cardioprotection by remote ischemic conditioning is transferable by plasma and mediated by extracellular vesicles.
Basic Research in Cardiology,
116(1), Article 16.
https://doi.org/10.1007/s00395-021-00856-w
Moldovan, L. I., Tsoi, L. C., Ranjitha, U., Hager, H., Weidinger, S., Gudjonsson, J. E.
, Kjems, J. & Kristensen, L. S. (2021).
Characterization of Circular RNA Transcriptomes in Psoriasis and Atopic Dermatitis Reveals Disease-specific Expression Profiles.
Experimental Dermatology,
30(8), 1187-1196.
https://doi.org/10.1111/exd.14227
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Cyclic hypoxia conditioning alters the content of myoblast-derived extracellular vesicles and enhances their cell-protective functions.
Biomedicines,
9(9), Article 1211.
https://doi.org/10.3390/biomedicines9091211
Hait, A. S., Olagnier, D., Sancho-Shimizu, V.
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Defects in LC3B2 and ATG4A underlie HSV2 meningitis and reveal a critical role for autophagy in antiviral defense in humans.
Science Immunology,
5(54), Article eabc2691.
https://doi.org/10.1126/sciimmunol.abc2691
Ahmadov, U., Bendikas, M. M., Ebbesen, K. K., Sehested, A. M.
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Distinct circular RNA expression profiles in pediatric ependymomas.
Brain Pathology,
31(2), 387-392.
https://doi.org/10.1111/bpa.12922
Gomes-Duarte, A., Bauer, S.
, Venø, M. T., Norwood, B. A., Henshall, D. C.
, Kjems, J., Rosenow, F., Vangoor, V. R. & Pasterkamp, R. J. (2021).
Enrichment of Circular RNA Expression Deregulation at the Transition to Recurrent Spontaneous Seizures in Experimental Temporal Lobe Epilepsy.
Frontiers in Genetics,
12, Article 627907.
https://doi.org/10.3389/fgene.2021.627907Jakobsen, T., Dahl, M., Dimopoulos, K., Grønbæk, K.
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Genome-wide circular RNA expression patterns reflect resistance to immunomodulatory drugs in multiple myeloma cells.
Cancers,
13(3), Article 365.
https://doi.org/10.3390/cancers13030365
Krissanaprasit, A., Key, C. M., Froehlich, K., Pontula, S., Mihalko, E.
, Dupont, D. M., Andersen, E. S., Kjems, J., Brown, A. C. & LaBean, T. H. (2021).
Multivalent Aptamer-Functionalized Single-Strand RNA Origami as Effective, Target-Specific Anticoagulants with Corresponding Reversal Agents.
Advanced Healthcare Materials,
10(11), Article 2001826.
https://doi.org/10.1002/adhm.202001826Lorenzi, L., Chiu, H. S., Avila Cobos, F., Gross, S., Volders, P. J., Cannoodt, R., Nuytens, J., Vanderheyden, K., Anckaert, J., Lefever, S., Tay, A. P., de Bony, E. J., Trypsteen, W., Gysens, F., Vromman, M., Goovaerts, T.
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The RNA Atlas expands the catalog of human non-coding RNAs.
Nature Biotechnology,
39(11), 1453-1465.
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, Venø, M. T., Esguerra, J. L. S., Barghouth, M., Suleiman, M., Marselli, L.
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A circular RNA generated from an intron of the insulin gene controls insulin secretion.
Nature Communications,
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https://doi.org/10.1038/s41467-020-19381-wDas Mahapatra, K., Pasquali, L., Søndergaard, J. N., Lapins, J., Nemeth, I. B., Baltás, E., Kemény, L., Homey, B.
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A comprehensive analysis of coding and non-coding transcriptomic changes in cutaneous squamous cell carcinoma.
Scientific Reports,
10, Article 3637.
https://doi.org/10.1038/s41598-020-59660-6Venø, M. T., Reschke, C. R., Morris, G., Connolly, N. M. C.
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A systems approach delivers a functional microRNA catalog and expanded targets for seizure suppression in temporal lobe epilepsy.
Proceedings of the National Academy of Sciences (PNAS),
117(27), 15977-15988.
https://doi.org/10.1073/pnas.1919313117
Ramsay, E., Raviña, M., Sarkhel, S., Hehir, S., Cameron, N. R., Ilmarinen, T., Skottman, H.
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& Subrizi, A. (2020).
Avoiding the pitfalls of siRNA delivery to the retinal pigment epithelium with physiologically relevant cell models.
Pharmaceutics,
12(7), Article 667.
https://doi.org/10.3390/pharmaceutics12070667Yoshimoto, R.
, Rahimi, K., Hansen, T. B., Kjems, J. & Mayeda, A. (2020).
Biosynthesis of Circular RNA ciRS-7/CDR1as Is Mediated by Mammalian-wide Interspersed Repeats.
iScience,
23(7), Article 101345.
https://doi.org/10.1016/j.isci.2020.101345Just, J., Yan, Y., Farup, J., Sieljacks, P., Sloth, M., Venø, M., Gu, T., de Paoli, F. V., Nyengaard, J. R., Bæk, R., Jørgensen, M. M.
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Blood flow-restricted resistance exercise alters the surface profile, miRNA cargo and functional impact of circulating extracellular vesicles.
Scientific Reports,
10(1), Article 5835.
https://doi.org/10.1038/s41598-020-62456-3
Kirkegaard, K., Yan, Y., Sørensen, B. S., Hardason, T., Hanson, C., Ingerslev, H. J.
, Knudsen, U. B., Kjems, J., Lundin, K. & Ahlström, A. (2020).
Comprehensive analysis of soluble RNAs in human embryo culture media and blastocoel fluid.
Journal of Assisted Reproduction and Genetics,
37(9), 2199–2209.
https://doi.org/10.1007/s10815-020-01891-7
Omer, M., Andersen, V. L., Nielsen, J. S., Wengel, J.
& Kjems, J. (2020).
Improved Cancer Targeting by Multimerizing Aptamers on Nanoscaffolds.
Molecular Therapy - Nucleic Acids,
22, 994-1003.
https://doi.org/10.1016/j.omtn.2020.10.013
Mortensen, M. R., Skovsgaard, M. B., Märcher, A., Andersen, V. L., Palmfeldt, J., Nielsen, T. B., Tørring, T., Laursen, N. S., Andersen, K. R., Kjems, J. & Gothelf, K. V. (2020).
Introduction of an Aldehyde Handle on Nanobodies by Affinity-Guided Labeling.
Bioconjugate Chemistry,
31(5), 1295-1300.
https://doi.org/10.1021/acs.bioconjchem.0c00151
Rajewsky, N., Almouzni, G., Gorski, S. A., Aerts, S., Amit, I., Bertero, M. G., Bock, C., Bredenoord, A. L., Cavalli, G., Chiocca, S., Clevers, H., De Strooper, B., Eggert, A., Ellenberg, J., Fernández, X. M., Figlerowicz, M., Gasser, S. M., Hubner, N.
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LifeTime and improving European healthcare through cell-based interceptive medicine.
Nature,
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Modulation of Small RNA Signatures in Schwann-Cell-Derived Extracellular Vesicles by the p75 Neurotrophin Receptor and Sortilin.
Biomedicines,
8(11), 1-24. Article 450.
https://doi.org/10.3390/biomedicines8110450
Yan, Y., Chang, C., Su, J., Venø, M. T. & Kjems, J. (2020).
Osteoblastogenesis Alters Small RNA Profiles in EVs Derived from Bone Marrow Stem Cells (BMSCs) and Adipose Stem Cells (ASCs).
Biomedicines,
8(10), 1-17. Article 387.
https://doi.org/10.3390/biomedicines8100387
Godskesen, L. E.
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, Yan, Y., Nielsen, M. M., Tjønnfjord, S. K., Grøntved, L., Madsen, G.
, Kjems, J., Bøtker, H. E., Schmidt, M. R., Krag, A. & Kjeldsen, J. (2020).
Remote ischemic conditioning in active ulcerative colitis: An explorative randomized clinical trial.
Scientific Reports,
10(1), Article 9537.
https://doi.org/10.1038/s41598-020-65692-9Kristensen, L. S., Ebbesen, K. K., Sokol, M., Jakobsen, T., Korsgaard, U., Eriksen, A. C.
, Hansen, T. B., Kjems, J. & Hager, H. (2020).
Spatial expression analyses of the putative oncogene ciRS-7 in cancer reshape the microRNA sponge theory.
Nature Communications,
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https://doi.org/10.1038/s41467-020-18355-2
Thomsen, R. P., Malle, M. G.
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, Sørensen, R. S., Ries, O., Vogel, S., Simmel, F. C., Hatzakis, N. S.
& Kjems, J. (2019).
A large size-selective DNA nanopore with sensing applications.
Nature Communications,
10(1), Article 5655.
https://doi.org/10.1038/s41467-019-13284-1
Høiberg, H. C., Sparvath, S. M., Andersen, V. L., Kjems, J. & Andersen, E. S. (2019).
An RNA origami octahedron with intrinsic siRNAs for potent gene knockdown.
Biotechnology Journal,
14(1), Article 1700634.
https://doi.org/10.1002/biot.201700634
Andersen, V. L., Vinther, M., Kumar, R., Ries, A., Wengel, J.
, Nielsen, J. S. & Kjems, J. (2019).
A self-assembled, modular nucleic acid-based nanoscaffold for multivalent theranostic medicine.
Theranostics,
9(9), 2662-2677.
https://doi.org/10.7150/thno.32060
Raniolo, S., Croce, S.
, Thomsen, R. P., Okholm, A. H., Unida, V., Iacovelli, F., Manetto, A.
, Kjems, J., Desideri, A. & Biocca, S. (2019).
Cellular uptake of covalent and non-covalent DNA nanostructures with different sizes and geometries.
Nanoscale,
11(22), 10808-10818.
https://doi.org/10.1039/c9nr02006c
