Junior Faculty Distinguished Lectures by Klaus Eyer, Biomedicine, AU and Asger Givskov, MGB, AU
This Friday, we would like to invite you to the semester’s first 'Junior Faculty Distinguished Lectures'. This initiative aims to give the junior faculty a platform to share their expertise and research. Twice a semester two junior faculty (tenure track and fixed-term assistant professors) will be invited to give a 20 min talk. We hope many will attend and engage with the speakers to explore shared interests and potential opportunities to collaboration.
10:15-10:35 Klaus Eyer: Beyond Immune Phenotypes: Measuring Function at the Single-Cell Level
10:40-11:00 Asger Givskov:
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Time
Organizer
Associate Professor Klaus Eyer, Department of Biomedicine, Aarhus University
Beyond Immune Phenotypes: Measuring Function at the Single-Cell Level
The immune system is composed of highly heterogeneous cells whose functional states cannot always be inferred from their identity or phenotype alone. While single-cell sequencing has transformed our ability to characterize immune-cell states, directly measuring what individual cells do remains challenging. Cells with similar phenotypic or molecular profiles can exhibit markedly different functional behaviours, such as the amount and dynamics of molecules they secrete, with potentially very different biological consequences.
The talk will highlight quantitative technologies combining microfluidics and single-cell analysis to directly measure cellular function and resolve this heterogeneity. In particular, measurements of secretion and its dynamics provide access to functional states obscured in population-level analyses. Integrating functional measurements with molecular and immune-repertoire information further enables cellular behaviour to be related to molecular identity. Together, these approaches open new avenues for quantitatively understanding immune responses and translating functional heterogeneity into biomedical applications.