Søren Degn

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Wittenborn, T. R., Hagert, C. & Degn, S. E. (2019). Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity. Journal of visualized experiments : JoVE, 2019(146), Article e59397. https://doi.org/10.3791/59397

Wittenborn, T. R., Hagert, C. F., Ferapontov, A., Fonager, S., Jensen, L., Winther, G. & Degn, S. E. (2021). Comparison of gamma and x-ray irradiation for myeloablation and establishment of normal and autoimmune syngeneic bone marrow chimeras. PLoS One, 16(3), Article e0247501. https://doi.org/10.1371/journal.pone.0247501

Wibrand, C., Wittenborn, T. R., Voss, L. F., Winther, G., Jensen, L., Ferapontov, A., Fonager, S. V., Fahlquist-Hagert, C. & Degn, S. E. (2023). B cell MHC haplotype affects follicular inclusion, germinal center participation and plasma cell differentiation in a mouse model of lupus. Frontiers in Immunology, 14, Article 1258046. https://doi.org/10.3389/fimmu.2023.1258046

Voss, L. F., Howarth, A. J., Wittenborn, T. R., Hummelgaard, S., Juul-Madsen, K., Kastberg, K. S., Pedersen, M. K., Jensen, L., Papanastasiou, A. D., Vorup-Jensen, T., Weyer, K. & Degn, S. E. (2022). The extrafollicular response is sufficient to drive initiation of autoimmunity and early disease hallmarks of lupus. Frontiers in Immunology, 13, Article 1021370. https://doi.org/10.3389/fimmu.2022.1021370

van der Poel, C. E., Bajic, G., Macaulay, C. W., van den Broek, T., Ellson, C. D., Bouma, G., Victora, G. D., Degn, S. E. & Carroll, M. C. (2019). Follicular Dendritic Cells Modulate Germinal Center B Cell Diversity through FcγRIIB. Cell Reports, 29(9), 2745-2755.e4. https://doi.org/10.1016/j.celrep.2019.10.086

Thiel, S., Kolev, M., Degn, S. E., Steffensen, R., Hansen, A., Ruseva, M. & Jensenius, J. C. (2009). Polymorphisms in mannan-binding lectin (MBL)-associated serine protease 2 affect stability, binding to MBL, and enzymatic activity. Journal of Immunology, 182(5), 2939-47. https://doi.org/10.4049/jimmunol.0802053

Thiel, S., Jensen, L., Degn, S. E., Nielsen, H. J., Gál, P., Dobó, J. & Jensenius, J. C. (2012). Mannan-binding lectin (MBL)-associated serine protease-1 (MASP-1), a serine protease associated with humoral pattern-recognition molecules: normal and acute-phase levels in serum and stoichiometry of lectin pathway components. Clinical and Experimental Immunology, Supplement, 169(1), 38-48. https://doi.org/10.1111/j.1365-2249.2012.04584.x

Sirinian, C., Papanastasiou, A. D., Degn, S. E., Frantzi, T., Aronis, C., Chaniotis, D., Makatsoris, T., Koutras, A. & Kalofonos, H. P. (2021). Rank-c expression sensitizes er-negative, egfr-positive breast cancer cells to egfr-tyrosine kinase inhibitors (Tkis). Genes, 12(11), Article 1686. https://doi.org/10.3390/genes12111686

Sirinian, C., Papanastasiou, A. D., Karayel, O., Degn, S. E., Peroukidis, S., Chaniotis, D., Nonni, A., Repanti, M., Kriegsmann, M., Makatsoris, T., Koutras, A., Mann, M. & Kalofonos, H. P. (2022). Analysis of RANK-c interaction partners identifies TRAF3 as a critical regulator of breast cancer aggressiveness. NeoPlasia, 33, Article 100836. https://doi.org/10.1016/j.neo.2022.100836

Sirinian, C., de Lastic, A. L., Zaverdas, H., Nifora, M., Georgakopoulou, D., Samiotaki, M., Argentou, M. I., Peroukidis, S., Degn, S. E., Rusan, M., Theofilatos, K., Mavroudi, S., Papanastasiou, A. D. & Koutras, A. (2026). Dual Role of Cancer Epithelial-Specific TRAF3 in Regulating Breast Cancer Cell Survival and Lymphocyte Activity. International Journal of Molecular Sciences , 27(10), Article 4414. https://doi.org/10.3390/ijms27104414

Rovsing, A. B., Green, K., Jensen, L., Nielsen, I. H., Mikkelsen, J. G. & Degn, S. E. (2025). Multiparametric Optimization of Human Primary B-Cell Cultures Using Design of Experiments. Scandinavian Journal of Immunology, 102(2), Article e70043. https://doi.org/10.1111/sji.70043

Rasmussen, M. Q., Tindbæk, G., Nielsen, M. M., Merrild, C., Steiniche, T., Pedersen, J. S., Moestrup, S. K., Degn, S. E. & Madsen, M. (2023). Epigenetic Silencing of LRP2 Is Associated with Dedifferentiation and Poor Survival in Multiple Solid Tumor Types. Cancers, 15(6), Article 1830. https://doi.org/10.3390/cancers15061830

Rasmussen, M. Q., Bønnelykke-Behrndtz, M. L., Merrild, C., Tvilling, I. K. S., Christensen, J. N., Nielsen, M. M., Georgsen, J. B., Naumann, N., Gudbergsson, J. M., Etzerodt, A., Pedersen, J. S., Jenkins, R. W., Degn, S. E., Moestrup, S. K., Schmidt, H., Steiniche, T. & Madsen, M. (2025). LRP2 Expression in Melanoma Is Associated With a Transitory Cell State, Increased T Cell Infiltration, and Is Upregulated by IFNy Signaling. Pigment Cell & Melanoma Research, 38(5), Article e70053. https://doi.org/10.1111/pcmr.70053

Psianou, K., Panagoulias, I., Papanastasiou, A. D., de Lastic, A.-L., Rodi, M., Spantidea, P. I., Degn, S. E., Georgiou, P. & Mouzaki, A. (2018). Clinical and immunological parameters of Sjögren's syndrome. Autoimmunity Reviews, 17(10), 1053-1064. https://doi.org/10.1016/j.autrev.2018.05.005

Pohl, L., Wittenborn, T. R., Shahrokhtash, A., Kastberg, K. S., Fahlquist-Hagert, C., Jensen, L., Pedersen, S. A., Demtröder, J. K., Sardella, D., Pulfer, A., Sutherland, D., Gonzalez, S. F., Schiessl, I. M. & Degn, S. E. (2026). Serial intravital microscopy reveals temporal dynamics of autoreactive germinal centers in the spleen. iScience, 29(4), Article 115340. https://doi.org/10.1016/j.isci.2026.115340

Pilati, D., Agyei, E. K., Elkhashab, M., Fuchs, E., Nielsen, I. H., Bjerg, T. W., Anthi, A. K., Jiménez-Reinoso, A., Iversen, M. B., Pohl, L., Narita, R., Frago, S., Jakobsen, M. R., Andersen, J. T., Degn, S. E., Paludan, S. R., Alvarez-Vallina, L. & Howard, K. A. (2025). Exploiting FcRn engagement of an albumin-CpG oligonucleotide covalent conjugate for potent TLR9 immune induction. Journal of Biological Chemistry, 301(6), Article 108508. https://doi.org/10.1016/j.jbc.2025.108508

Pedersen, K., Green, K., Kristoffersen, E. L., Schinkel, T., Hansen, A. G., Palarasah, Y., Rovsing, A. B., Andersen, E. S., Valero, J., Civit, L., Laursen, N. S., Troldborg, A., Degn, S. E. & Thiel, S. (2026). Curbing Autoimmunity: A New Fab Fragment Targeting CD40-CD40L Halts B-Cell Activation and Differentiation. European Journal of Immunology, 56(2), Article e70158. https://doi.org/10.1002/eji.70158

Nielsen, I. H., Rovsing, A. B., Janns, J. H., Thomsen, E. A., Ruzo, A., Bøggild, A., Nedergaard, F., Møller, C. T., Boesen, T., Degn, S. E., Shah, J. V. & Mikkelsen, J. G. (2024). Cell-targeted gene modification by delivery of CRISPR-Cas9 ribonucleoprotein complexes in pseudotyped lentivirus-derived nanoparticles. Molecular Therapy Nucleic Acids, 35(4), Article 102318. https://doi.org/10.1016/j.omtn.2024.102318

Mortensen, S. A., Skov, L. L., Kjaer-Sorensen, K., Hansen, A. G., Hansen, S., Dagnæs-Hansen, F., Jensenius, J. C., Oxvig, C., Thiel, S. & Degn, S. E. (2017). Endogenous Natural Complement Inhibitor Regulates Cardiac Development. Journal of Immunology, 198(8), 3118-3126. https://doi.org/10.4049/jimmunol.1601958

Morsing, A. E., Green, K., Clausen, S., Benjaminsen, C. R., Blaavand, M. S., Demtröder, J. K., Skraep, J., Jensen, L., Breining, P., Kjolby, M., Vendelbo, M., Degn, S. E. & Thomsen, M. K. (2025). Age-associated B cells enhance tertiary lymphoid structures in the liver and promote HCC formation. Hepatology Communications, 9(10), Article e0816. https://doi.org/10.1097/HC9.0000000000000816

Krimpenfort, L. T., Degn, S. E. & Heesters, B. A. (2024). The follicular dendritic cell: At the germinal center of autoimmunity? Cell Reports, 43(3), Article 113869. https://doi.org/10.1016/j.celrep.2024.113869

Juul-Madsen, K., Troldborg, A., Wittenborn, T. R., Axelsen, M. G., Zhao, H., Klausen, L. H., Luecke, S., Paludan, S. R., Stengaard-Pedersen, K., Dong, M., Møller, H. J., Thiel, S., Jensen, H., Schuck, P., Sutherland, D. S., Degn, S. E. & Vorup-Jensen, T. (2021). Characterization of DNA-protein complexes by nanoparticle tracking analysis and their association with systemic lupus erythematosus. Proceedings of the National Academy of Sciences (PNAS), 118(30), Article e2106647118. https://doi.org/10.1073/pnas.2106647118

Joseph, J. V., Blaavand, M. S., Cai, H., Vernejoul, F., Knopper, R. W., Lindhardt, T. B., Skipper, K. A., Axelgaard, E., Reinert, L., Mikkelsen, J. G., Borghammer, P., Degn, S. E., Perouzel, E., Hager, H., Hansen, B., Kalucka, J. M., Vendelbo, M., Paludan, S. R. & Thomsen, M. K. (2023). STING activation counters glioblastoma by vascular alteration and immune surveillance. Cancer Letters, 579, Article 216480. https://doi.org/10.1016/j.canlet.2023.216480

He, M., D'Aulerio, R., Pinho, L. G., Doukoumopoulos, E., Yong, T., Vieira, R. C., Oliveira, M. M. S., Eiben, L., Termote, M., Galvani, R. G., Sedimbi, S., Seitz, C., Kuznetsov, N. V., Zuriaga, M. A., Kitamura, D., Fuster, J. J., Cotta-de-Almeida, V., Ström, L., Dosenovic, P. ... Westerberg, L. S. (2026). AID and TET2 cooperate to demethylate Irf4 for plasma cell fate in germinal center B cells. The Journal of Experimental Medicine, 223(6). https://doi.org/10.1084/jem.20260096

Hagert, C. F., Bohn, A. B., Wittenborn, T. R. & Degn, S. E. (2020). Seeing the Confetti Colors in a New Light Utilizing Flow Cytometry and Imaging Flow Cytometry. Cytometry. Part A, 97(8), 811-823. https://doi.org/10.1002/cyto.a.24032

Green, K., Wittenborn, T. R., Fahlquist-Hagert, C., Terczynska-Dyla, E., van Campen, N., Jensen, L., Reinert, L., Hartmann, R., Paludan, S. R. & Degn, S. E. (2021). B Cell Intrinsic STING Signaling Is Not Required for Autoreactive Germinal Center Participation. Frontiers in Immunology, 12, Article 782558. https://doi.org/10.3389/fimmu.2021.782558

Gonzalez, S. F., Degn, S. E., Pitcher, L. A., Woodruff, M., Heesters, B. A. & Carroll, M. C. (2011). Trafficking of B cell antigen in lymph nodes. Annual Review of Immunology, 29, 215-233.

Gonzalez, S. F., Lukacs-Kornek, V., Kuligowski, M. P., Pitcher, L. A., Degn, S. E., Turley, S. J. & Carroll, M. C. (2010). Complement-dependent transport of antigen into B cell follicles. Journal of Immunology, 185, 2659-2664.

Gonzalez, S. F., Lukacs-Kornek, V., Kuligowski, M. P., Pitcher, L. A., Degn, S. E., Kim, Y.-A., Cloninger, M. J., Martinez-Pomares, L., Gordon, S., Turley, S. J. & Carroll, M. C. (2010). Capture of influenza by medullary dendritic cells via SIGN-R1 is essential for humoral immunity in draining lymph nodes. Nature Immunology, 11(5), 427-435.