Interdisciplinary Nanoscience Center

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Publications

Professor Jørgen Kjems

Recent publications

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Demaegd, K. C., Kool, L., Baindoor, S., Donovan, P. D., Su, J., Westeneng, H. J., van Eijk, R. P. A., Geoghegan, G., Perez Morrissey, E., Halang, L., Poesen, K., Masrori, P., Gibriel, H. A. Y., Jirström, E., Venø, M. T., Kjems, J., Hardiman, O., Veldink, J. H., Kenna, K. ... van Es, M. A. (2026). Small RNA sequencing identifies serum tDR-1:34-Gly-GCC tiRNA levels as a biomarker for survival in amyotrophic lateral sclerosis. iScience, 29(5), Article 115636. https://doi.org/10.1016/j.isci.2026.115636
Vinther, S. C., Resag, A., Le, K. T. T., Zelle-Rieser, C. C., Strandt, H., Malle, M. G., Christiansen, S. H., Del Frari, B., Stigger, T., Schilling, B., Wohlfarth, J., Thiel, S., Valero, J., Stoitzner, P. & Kjems, J. (2026). Targeting Langerhans cells using a modular mannosylated nucleic acid-based vaccine platform. Journal of Controlled Release, 392, 114741. Article 114741. https://doi.org/10.1016/j.jconrel.2026.114741
Cerda-Jara, C. A., Scoyni, F., Zolotarov, G., Bhaskar, P., León-Periñán, D., Kjems, J. & Rajewsky, N. (2026). The history and function of a circular RNA. Nature Communications, 17(1), Article 3862. https://doi.org/10.1038/s41467-026-71822-0
Søkilde, R., Kaadt, E., Kristensen, L. S., Venø, M. T., Kjems, J., Nyengaard, J. R., Nielsen, B. S. & Elfving, B. (2025). Application of microRNA In Situ Hybridization on Long-term Stored Human Formalin-fixed Paraffin-embedded Brain Samples from Psychiatric Patients. Molecular Neurobiology, 62(10), 12736-12746. https://doi.org/10.1007/s12035-025-05077-z
Samanta, A., Malle, M. G., Tsang, E., Omer, M., Skaanning, M. K., Kjems, J. & Gothelf, K. V. (2025). Bacteriophage-Mimetic DNA Origami Needle for Targeted Membrane Penetration and Cytosolic Cargo Delivery. bioRxiv. https://doi.org/10.1101/2025.06.16.659898

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Professor Duncan Sutherland

Recent publications

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Holleufer, S. F., Hopkinson, A. T., Sutherland, D. S., Li, Z., Lauritsen, J. V., Hornekær, L. & Cassidy, A. (2025). Silicon oxide nanoparticles grown on graphite by co-deposition of the atomic constituents. Physical Chemistry Chemical Physics, 27(26), 13906-13916. https://doi.org/10.1039/d5cp01089f
Baami González, X., Leidinger, P. M., Rente, B., Bower, R., Lauritsen, J. V., Petrov, P. K. & Sutherland, D. S. (2025). Thermally Robust Plasmonic Nanorings from Titanium Nitride. ACS Omega, 10(39), 46176-46187. https://doi.org/10.1021/acsomega.5c08679
Baami González, X., Petrov, P. K. & Sutherland, D. S. (2025). Thermoplasmonic Nanorings via Sputter Deposition. Materials, 18(18), Article 4371. https://doi.org/10.3390/ma18184371
Juul-Madsen, K., Parbo, P., Ismail, R., Ovesen, P. L., Schmidt, V., Madsen, L. S., Thyrsted, J., Gierl, S., Breum, M., Larsen, A., Andersen, M. N., Romero-Ramos, M., Holm, C. K., Andersen, G. R., Zhao, H., Schuck, P., Nygaard, J. V., Sutherland, D. S., Eskildsen, S. F. ... Vorup-Jensen, T. (2024). Amyloid-β aggregates activate peripheral monocytes in mild cognitive impairment. Nature Communications, 15(1), Article 1224. https://doi.org/10.1038/s41467-024-45627-y
Ghorbani, S. & Sutherland, D. S. (2024). Building better habitats: Spatiotemporal signaling cues in 3D biointerfaces for tailored cellular functionality. Biointerphases, 19(4), Article 048501. https://doi.org/10.1116/6.0003685

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Tenure-track assistant professor Julián Valero

Recent publications

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Malle, M. G., Song, P., Löffler, P. M. G., Kalisi, N., Yan, Y., Valero, J., Vogel, S. & Kjems, J. (2024). Programmable RNA Loading of Extracellular Vesicles with Toehold-Release Purification. Journal of the American Chemical Society, 146(18), 12410-12422. https://doi.org/10.1021/JACS.3C13123
Ma, Y., Yu, Z. & Valero, J. (2024). Recent Advances on Catenanes and Rotaxanes Made of DNA. In E. M. Pérez (Ed.), Mechanically Interlocked Materials: Polymers, Nanomaterials, MOFs, and more (pp. 195-216). Wiley.
Zhang, X., Galenkamp, N. S., Heide, N. J. V. D., Valero Moreno, J., Maglia, G. & Kjems, J. (2023). Specific Detection of Proteins by a Nanobody-Functionalized Nanopore Sensor. ACS Nano, 17(10), 9167-9177. https://doi.org/10.1021/acsnano.2c12733
Yu, Z., Centola, M., Valero, J., Matthies, M., Šulc, P. & Famulok, M. (2021). A Self-Regulating DNA Rotaxane Linear Actuator Driven by Chemical Energy. Journal of the American Chemical Society, 143(33), 13292-13298. https://doi.org/10.1021/jacs.1c06226
Valero, J., Civit, L., Dupont, D. M., Selnihhin, D., Reinert, L. S., Idorn, M., Israels, B. A., Bednarz, A. M., Bus, C., Asbach, B., Peterhoff, D., Pedersen, F. S., Birkedal, V., Wagner, R., Paludan, S. R. & Kjems, J. (2021). A serum-stable RNA aptamer specific for SARS-CoV-2 neutralizes viral entry. Proceedings of the National Academy of Sciences (PNAS), 118(50), Article e2112942118. https://doi.org/10.1073/pnas.2112942118

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Professor Steffen Thiel

Recent publications

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Sagedal, S., Hovd, M., Åsberg, A., Mollnes, T. E., Klingenberg, O., Heldal, T. F., Witczak, B. J., Hejlesen, T. K., Troldborg, A. & Thiel, S. (2025). Increased levels of ficolin-1 and of C3dg are independently associated with high risk of infection in patients with chronic kidney disease: a prospective cohort study. Frontiers in Immunology, 16, Article 1645347. https://doi.org/10.3389/fimmu.2025.1645347
Larsen, M. L., Nørgaard, L., Linge, P., Larsen, J. B., Langkilde, H. Z., Hauge, E. M., Thiel, S., Voss, A., Bengtsson, A. & Troldborg, A. (2025). Molecular mechanisms underlying thrombosis in systemic lupus erythematosus: A Systematic review. Seminars in Arthritis and Rheumatism, 72, Article 152707. https://doi.org/10.1016/j.semarthrit.2025.152707
Jensen, E. G., Jakobsen, T. S., Schnabolk, G., Wilson, K., Rask-Pedersen, M., Jensen, N., Andersen, G. R., Thiel, S., Aagaard, L., Rohrer, B., Askou, A. L. & Corydon, T. J. (2025). Nanobody-based gene therapy targeting complement component C3 reduces choroidal neovascularization in mice. Molecular Therapy Methods and Clinical Development, 33(4), Article 101620. https://doi.org/10.1016/j.omtm.2025.101620
Jensen, M., Nielsen, S. F., Thiel, S., Hansen, S. W. K., Palarasah, Y., Svenningsen, P., Bech, J. N., Mose, F. H. & Jensen, B. L. (2025). Pilot Study of Sodium-Glucose Cotransporter 2 Inhibitor Empagliflozin Shows Reduced Intrarenal Complement Activation in Patients With Diabetes and CKD. Kidney International Reports, 10(2), 591-595. https://doi.org/10.1016/j.ekir.2024.11.014, https://doi.org/10.1016/j.ekir.2024.11.014
Demir, F., Kovalenko, E., Lassé, M., Svenningsen, E. B., Bernth Jensen, J. M., Billing, A. M., Groeneveld, K., Hutzfeldt, A., Nilges, L., Guerra, J. P. L., Pietrzak-Lichwa, K. J., Tan, Y., Colby, E., Hansen, A. G., Kurmasheva, N., Olagnier, D., Choi, D., Richter, M. M., Laufer, S. D. ... Rinschen, M. M. (2025). Proteolytic profiling of human plasma reveals an immunoactive complement C3 fragment. EMBO Journal, 44(24), 7721-7758. https://doi.org/10.1038/s44318-025-00598-8

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Professor Søren Degn

Recent publications

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Fonager, S. V., Winther, G., Weber, Y. C. L., Wittenborn, T. R., Kastberg, K. S., Terczyńska-Dyla, E., Jensen, L., Hansen, L. A., Carroll, M. C., Luo, Y., Lin, L. & Degn, S. E. (2025). Maternal imprinting of autoreactivity in a murine model of systemic lupus erythematosus. Brain, Behavior, and Immunity, 129, 921-934. https://doi.org/10.1016/j.bbi.2025.07.025
Rovsing, A. B., Green, K., Jensen, L., Nielsen, I. H., Mikkelsen, J. G. & Degn, S. E. (2025). Multiparametric Optimization of Human Primary B-Cell Cultures Using Design of Experiments. Scandinavian Journal of Immunology, 102(2), Article e70043. https://doi.org/10.1111/sji.70043
Degn, S. E. & Tolar, P. (2025). Towards a unifying model for B-cell receptor triggering. Nature Reviews Immunology, 25(2), 77-91. Article 976. https://doi.org/10.1038/s41577-024-01073-x
Nielsen, I. H., Rovsing, A. B., Janns, J. H., Thomsen, E. A., Ruzo, A., Bøggild, A., Nedergaard, F., Møller, C. T., Boesen, T., Degn, S. E., Shah, J. V. & Mikkelsen, J. G. (2024). Cell-targeted gene modification by delivery of CRISPR-Cas9 ribonucleoprotein complexes in pseudotyped lentivirus-derived nanoparticles. Molecular Therapy Nucleic Acids, 35(4), Article 102318. https://doi.org/10.1016/j.omtn.2024.102318
Fahlquist-Hagert, C., Wittenborn, T. R., Ferapontov, A., Jensen, L., Terczyńska-Dyla, E. & Degn, S. E. (2024). Haplosufficiency of MHCII in autoreactive germinal center B cells. European Journal of Immunology, 54(1), Article 2350422. https://doi.org/10.1002/eji.202350422

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Professor Fiona Watt

Professor Dr. Ralf Jungmann

Revised 08.12.2025
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Anne Færch Nielsen