Interdisciplinary Nanoscience Center

CellPAT

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Publications

Professor Jørgen Kjems

Recent publications

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Søkilde, R., Kaadt, E., Kristensen, L. S., Venø, M. T., Kjems, J., Nyengaard, J. R., Nielsen, B. S. & Elfving, B. (2025). Application of microRNA In Situ Hybridization on Long-term Stored Human Formalin-fixed Paraffin-embedded Brain Samples from Psychiatric Patients. Molecular Neurobiology, 62(10), 12736-12746. https://doi.org/10.1007/s12035-025-05077-z
Samanta, A., Malle, M. G., Tsang, E., Omer, M., Skaanning, M. K., Kjems, J. & Gothelf, K. V. (2025). Bacteriophage-Mimetic DNA Origami Needle for Targeted Membrane Penetration and Cytosolic Cargo Delivery. bioRxiv. https://doi.org/10.1101/2025.06.16.659898
García-Rodríguez, J. L., Korsgaard, U., Vissing, S. M., Paasch, T. P., Semenova, M., Vendelbo, S. L., Jensby, E. F., Williams, H. L., Salachan, P. V., Brandt, C. B., Hanimann, J., Lin, L., Zlobec, I., Sørensen, K. D., Kjems, J., Hager, H. & Kristensen, L. S. (2025). Cancer-associated fibroblasts shape the formation of budding cancer cells at the invasive front of human colorectal cancer. Communications Biology, 8(1), Article 1345. https://doi.org/10.1038/s42003-025-08799-x
Paasch, T. P., Olesen, M. T. J., García-Rodríguez, J. L., Assmus, A. M., Fenton, R. A., Kjems, J., Hager, H. & Kristensen, L. S. (2025). ciRS-7 expression is epigenetically regulated in cancer cells across human adenocarcinomas. PLoS Genetics, 21(6), Article e1011726. https://doi.org/10.1371/journal.pgen.1011726
Kjær, M. B., Jørgensen, A. G., Fjelstrup, S., Dupont, D. M., Bus, C., Eriksen, P. L., Thomsen, K. L., Risikesan, J., Nielsen, S., Wernberg, C. W., Lauridsen, M. M., Bugianesi, E., Rosso, C., Grønbæk, H. & Kjems, J. (2025). Diagnosis and Staging of Metabolic Dysfunction-Associated Steatotic Liver Disease Using Biomarker-Directed Aptamer Panels. Biomolecules, 15(2), Article 255. https://doi.org/10.3390/biom15020255

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Professor Duncan Sutherland

Recent publications

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Holleufer, S. F., Hopkinson, A. T., Sutherland, D. S., Li, Z., Lauritsen, J. V., Hornekær, L. & Cassidy, A. (2025). Silicon oxide nanoparticles grown on graphite by co-deposition of the atomic constituents. Physical Chemistry Chemical Physics, 27(26), 13906-13916. https://doi.org/10.1039/d5cp01089f
Baami González, X., Leidinger, P. M., Rente, B., Bower, R., Lauritsen, J. V., Petrov, P. K. & Sutherland, D. S. (2025). Thermally Robust Plasmonic Nanorings from Titanium Nitride. ACS Omega, 10(39), 46176-46187. https://doi.org/10.1021/acsomega.5c08679
Baami González, X., Petrov, P. K. & Sutherland, D. S. (2025). Thermoplasmonic Nanorings via Sputter Deposition. Materials, 18(18), Article 4371. https://doi.org/10.3390/ma18184371
Juul-Madsen, K., Parbo, P., Ismail, R., Ovesen, P. L., Schmidt, V., Madsen, L. S., Thyrsted, J., Gierl, S., Breum, M., Larsen, A., Andersen, M. N., Romero-Ramos, M., Holm, C. K., Andersen, G. R., Zhao, H., Schuck, P., Nygaard, J. V., Sutherland, D. S., Eskildsen, S. F. ... Vorup-Jensen, T. (2024). Amyloid-β aggregates activate peripheral monocytes in mild cognitive impairment. Nature Communications, 15(1), Article 1224. https://doi.org/10.1038/s41467-024-45627-y
Ghorbani, S. & Sutherland, D. S. (2024). Building better habitats: Spatiotemporal signaling cues in 3D biointerfaces for tailored cellular functionality. Biointerphases, 19(4), Article 048501. https://doi.org/10.1116/6.0003685

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Tenure-track assistant professor Julián Valero

Recent publications

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Ma, Y., Yu, Z. & Valero, J. (2024). Recent Advances on Catenanes and Rotaxanes Made of DNA. In E. M. Pérez (Ed.), Mechanically Interlocked Materials: Polymers, Nanomaterials, MOFs, and more (pp. 195-216). Wiley.
Zhang, X., Galenkamp, N. S., Heide, N. J. V. D., Valero Moreno, J., Maglia, G. & Kjems, J. (2023). Specific Detection of Proteins by a Nanobody-Functionalized Nanopore Sensor. ACS Nano, 17(10), 9167-9177. https://doi.org/10.1021/acsnano.2c12733
Yu, Z., Centola, M., Valero, J., Matthies, M., Šulc, P. & Famulok, M. (2021). A Self-Regulating DNA Rotaxane Linear Actuator Driven by Chemical Energy. Journal of the American Chemical Society, 143(33), 13292-13298. https://doi.org/10.1021/jacs.1c06226
Valero, J., Civit, L., Dupont, D. M., Selnihhin, D., Reinert, L. S., Idorn, M., Israels, B. A., Bednarz, A. M., Bus, C., Asbach, B., Peterhoff, D., Pedersen, F. S., Birkedal, V., Wagner, R., Paludan, S. R. & Kjems, J. (2021). A serum-stable RNA aptamer specific for SARS-CoV-2 neutralizes viral entry. Proceedings of the National Academy of Sciences (PNAS), 118(50), Article e2112942118. https://doi.org/10.1073/pnas.2112942118
Valero, J. & Skugor, M. (2020). Mechanisms, Methods of Tracking and Applications of DNA Walkers: A Review. ChemPhysChem, 21(17), 1971-1988. https://doi.org/10.1002/cphc.202000235

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Professor Steffen Thiel

Recent publications

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Larsen, M. L., Nørgaard, L., Linge, P., Larsen, J. B., Langkilde, H. Z., Hauge, E. M., Thiel, S., Voss, A., Bengtsson, A. & Troldborg, A. (2025). Molecular mechanisms underlying thrombosis in systemic lupus erythematosus: A Systematic review. Seminars in Arthritis and Rheumatism, 72, Article 152707. https://doi.org/10.1016/j.semarthrit.2025.152707
Jensen, E. G., Jakobsen, T. S., Schnabolk, G., Wilson, K., Rask-Pedersen, M., Jensen, N., Andersen, G. R., Thiel, S., Aagaard, L., Rohrer, B., Askou, A. L. & Corydon, T. J. (2025). Nanobody-based gene therapy targeting complement component C3 reduces choroidal neovascularization in mice. Molecular Therapy Methods and Clinical Development, 33(4), Article 101620. https://doi.org/10.1016/j.omtm.2025.101620
Jensen, M., Nielsen, S. F., Thiel, S., Hansen, S. W. K., Palarasah, Y., Svenningsen, P., Bech, J. N., Mose, F. H. & Jensen, B. L. (2025). Pilot Study of Sodium-Glucose Cotransporter 2 Inhibitor Empagliflozin Shows Reduced Intrarenal Complement Activation in Patients With Diabetes and CKD. Kidney International Reports, 10(2), 591-595. https://doi.org/10.1016/j.ekir.2024.11.014, https://doi.org/10.1016/j.ekir.2024.11.014
Demir, F., Kovalenko, E., Lassé, M., Svenningsen, E. B., Bernth Jensen, J. M., Billing, A. M., Groeneveld, K., Hutzfeldt, A., Nilges, L., Guerra, J. P. L., Pietrzak-Lichwa, K. J., Tan, Y., Colby, E., Hansen, A. G., Kurmasheva, N., Olagnier, D., Choi, D., Richter, M. M., Laufer, S. D. ... Rinschen, M. M. (2025). Proteolytic profiling of human plasma reveals an immunoactive complement C3 fragment. EMBO Journal, 44(24), 7721-7758. https://doi.org/10.1038/s44318-025-00598-8
Pedersen, K., Hansen, A. G., Palarasah, Y., Troldborg, A. & Thiel, S. (2025). Treat-To-Target: Emergence of Second-Generation CD40L Inhibitors for Treatment of SLE-Identifying Beneficial Patient Candidates for CD40L Inhibitors in a Cross-Sectional SLE Cohort. Scandinavian Journal of Immunology, 102(3), Article e70050. https://doi.org/10.1111/sji.70050

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Professor Søren Degn

Recent publications

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Nielsen, I. H., Rovsing, A. B., Janns, J. H., Thomsen, E. A., Ruzo, A., Bøggild, A., Nedergaard, F., Møller, C. T., Boesen, T., Degn, S. E., Shah, J. V. & Mikkelsen, J. G. (2024). Cell-targeted gene modification by delivery of CRISPR-Cas9 ribonucleoprotein complexes in pseudotyped lentivirus-derived nanoparticles. Molecular Therapy Nucleic Acids, 35(4), Article 102318. https://doi.org/10.1016/j.omtn.2024.102318
Fahlquist-Hagert, C., Wittenborn, T. R., Ferapontov, A., Jensen, L., Terczyńska-Dyla, E. & Degn, S. E. (2024). Haplosufficiency of MHCII in autoreactive germinal center B cells. European Journal of Immunology, 54(1), Article 2350422. https://doi.org/10.1002/eji.202350422
Fahlquist-Hagert, C., Wittenborn, T. R., Pedersen, M. K., Jensen, L. & Degn, S. E. (2024). T-follicular regulatory cells expand to control germinal center plasma cell output but fail to curb autoreactivity. iScience, 27(10), Article 110887. https://doi.org/10.1016/j.isci.2024.110887
Krimpenfort, L. T., Degn, S. E. & Heesters, B. A. (2024). The follicular dendritic cell: At the germinal center of autoimmunity? Cell Reports, 43(3), Article 113869. https://doi.org/10.1016/j.celrep.2024.113869
Ferapontov, A., Omer, M., Baudrexel, I., Nielsen, J. S., Dupont, D. M., Juul-Madsen, K., Steen, P., Eklund, A. S., Thiel, S., Vorup-Jensen, T., Jungmann, R., Kjems, J. & Degn, S. E. (2023). Antigen footprint governs activation of the B cell receptor. Nature Communications, 14(1), Article 976. https://doi.org/10.1038/s41467-023-36672-0

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Professor Fiona Watt

Professor Dr. Ralf Jungmann

Revised 08.12.2025
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Anne Færch Nielsen