JØRGEN KJEMS: Nanomedicine

There are three main focus areas in the Kjems lab:

a) The understanding of how small non-coding RNA and circular RNA contribute to cell maintenance and disease development with a primary aim of defining new targets for disease intervention.

b) The creation of novel bioimaging and delivery systems for gene medicine including siRNA, miRNA mimics, antimiRs (antisense targeting microRNA) with a specific focus on inflammation, cancer, influenza, and regeneration of damaged tissue (tissue engineering).

c) Design and construction of functionalized self assembled DNA and RNA nanostructures capable of complex biosensing, coupled with controlled action e.g. drug release, enzyme activation, and receptor signaling.

In CellPAT, Jørgen Kjems contributes with key expertises in applied nanotechnology including biomolecular design, bioconjugation, cell delivery and tissue engineering as well as the more basic molecular biology fields of gene expression and cellular growth and development.

Recent publications

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Sun, M., Chen, M., Wang, M., Hansen, J., Baatrup, A., Dagnæs-Hansen, F., Rölfing, J. D., Jensen, J., Lysdahl, H., Li, H., Johannsen, M., Le, D. Q. S., Kjems, J. & Bünger, C. (2016). In vivo drug release behavior and osseointegration of a doxorubicin-loaded tissue-engineered scaffold. RSC Advances, 6(80), 76237-76245. https://doi.org/10.1039/c6ra05351c

Svenningsen, K., Venø, M. T., Henningsen, K., Mallien, A. S., Jensen, L., Christensen, T., Kjems, J., Vollmayr, B. & Wiborg, O. (2016). MicroRNA Profiling in the Medial and Lateral Habenula of Rats Exposed to the Learned Helplessness Paradigm: Candidate Biomarkers for Susceptibility and Resilience to Inescapable Shock. PLoS One, 11(8), Article e0160318. https://doi.org/10.1371/journal.pone.0160318

Henshall, D. C., Hamer, H. M., Pasterkamp, R. J., Goldstein, D. B., Kjems, J., Prehn, J. H. M., Schorge, S., Lamottke, K. & Rosenow, F. (2016). MicroRNAs in epilepsy: pathophysiology and clinical utility. Lancet Neurology, 15(13), 1368-1376. https://doi.org/10.1016/S1474-4422(16)30246-0

Martirosyan, A., Olesen, M. J., Fenton, R. A., Kjems, J. & Howard, K. A. (2016). Mucin-mediated nanocarrier disassembly for triggered uptake of oligonucleotides as a delivery strategy for the potential treatment of mucosal tumours. Nanoscale, 8(25), 12599-12607. https://doi.org/10.1039/c5nr07206a

Lou, C., Martos-Maldonado, M. C., Madsen, C. S., Thomsen, R. P., Midtgaard, S. R., Christensen, N. J., Kjems, J., Thulstrup, P. W., Wengel, J. & Jensen, K. J. (2016). Peptide-oligonucleotide conjugates as nanoscale building blocks for assembly of an artificial three-helix protein mimic. Nature Communications, 7, Article 12294. https://doi.org/10.1038/ncomms12294

Displaying results 176 to 180 out of 440

Full list of publications

Group leader

Group members

Lab website

Revised 08.12.2025

Rikke Ploug Frydenberg