JØRGEN KJEMS: Nanomedicine

There are three main focus areas in the Kjems lab:

a) The understanding of how small non-coding RNA and circular RNA contribute to cell maintenance and disease development with a primary aim of defining new targets for disease intervention.

b) The creation of novel bioimaging and delivery systems for gene medicine including siRNA, miRNA mimics, antimiRs (antisense targeting microRNA) with a specific focus on inflammation, cancer, influenza, and regeneration of damaged tissue (tissue engineering).

c) Design and construction of functionalized self assembled DNA and RNA nanostructures capable of complex biosensing, coupled with controlled action e.g. drug release, enzyme activation, and receptor signaling.

In CellPAT, Jørgen Kjems contributes with key expertises in applied nanotechnology including biomolecular design, bioconjugation, cell delivery and tissue engineering as well as the more basic molecular biology fields of gene expression and cellular growth and development.

Recent publications

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Heiland, M., Connolly, N. M. C., Mamad, O., Nguyen, N. T., Kesavan, J. C., Langa, E., Fanning, K., Sanfeliu, A., Yan, Y., Su, J., Venø, M. T., Costard, L. S., Neubert, V., Engel, T., Hill, T. D. M., Freiman, T. M., Mahesh, A., Tiwari, V. K., Rosenow, F. ... Henshall, D. C. (2023). MicroRNA-335-5p suppresses voltage-gated sodium channel expression and may be a target for seizure control. Proceedings of the National Academy of Sciences (PNAS), 120(30), e2216658120. Article e2216658120. https://doi.org/10.1073/pnas.2216658120

Ghorbani, S., Christine Füchtbauer, A., Møllebjerg, A., Møller Martensen, P., Hvidbjerg Laursen, S., Christian Evar Kraft, D., Kjems, J., Meyer, R. L., Rahimi, K., Foss, M., Füchtbauer, E. M. & Sutherland, D. S. (2023). Protein ligand and nanotopography separately drive the phenotype of mouse embryonic stem cells. Biomaterials, 301, Article 122244. https://doi.org/10.1016/j.biomaterials.2023.122244

García-Rodríguez, J. L., Korsgaard, U., Ahmadov, U., Jarlstad Olesen, M. T., Dietrich, K.-G., Hansen, E. B., Vissing, S. M., Ulhøi, B. P., Dyrskjøt, L., Sørensen, K. D., Kjems, J., Hager, H. & Kristensen, L. S. (2023). Spatial profiling of circular RNAs in cancer reveals high expression in muscle and stromal cells. Cancer Research, 83(20), 3340–3353. https://doi.org/10.1158/0008-5472.CAN-23-0748

Zhang, X., Galenkamp, N. S., Heide, N. J. V. D., Valero Moreno, J., Maglia, G. & Kjems, J. (2023). Specific Detection of Proteins by a Nanobody-Functionalized Nanopore Sensor. ACS Nano, 17(10), 9167-9177. https://doi.org/10.1021/acsnano.2c12733

Reinhold, D., Farztdinov, V., Yan, Y., Meisel, C., Sadlowski, H., Kühn, J., Perschel, F. H., Endres, M., Düzel, E., Vielhaber, S., Guttek, K., Goihl, A., Venø, M., Teegen, B., Stöcker, W., Stubbemann, P., Kurth, F., Sander, L. E., Ralser, M. ... Körtvelyessy, P. (2023). The brain reacting to COVID-19: analysis of the cerebrospinal fluid proteome, RNA and inflammation. Journal of Neuroinflammation, 20, Article 30. https://doi.org/10.1186/s12974-023-02711-2

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Full list of publications

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Revised 08.12.2025

Rikke Ploug Frydenberg