JØRGEN KJEMS: Nanomedicine

There are three main focus areas in the Kjems lab:

a) The understanding of how small non-coding RNA and circular RNA contribute to cell maintenance and disease development with a primary aim of defining new targets for disease intervention.

b) The creation of novel bioimaging and delivery systems for gene medicine including siRNA, miRNA mimics, antimiRs (antisense targeting microRNA) with a specific focus on inflammation, cancer, influenza, and regeneration of damaged tissue (tissue engineering).

c) Design and construction of functionalized self assembled DNA and RNA nanostructures capable of complex biosensing, coupled with controlled action e.g. drug release, enzyme activation, and receptor signaling.

In CellPAT, Jørgen Kjems contributes with key expertises in applied nanotechnology including biomolecular design, bioconjugation, cell delivery and tissue engineering as well as the more basic molecular biology fields of gene expression and cellular growth and development.

Recent publications

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Veno, M. T., Veno, S. T., Rehberg, K., van Asperen, J. V., Clausen, B. H., Holm, I. E., Pasterkamp, R. J., Finsen, B. & Kjems, J. (2017). Cortical Morphogenesis during Embryonic Development Is Regulated by miR-34c and miR-204. Frontiers in Molecular Neuroscience, 10(31), Article 31. https://doi.org/10.3389/fnmol.2017.00031

Vangoor, V. R., Giuliani, G., de Wit, M., Rangel, C. K., Venø, M. T., Schulte, J. T., Gomes-Duarte, A., Senthilkumar, K., Puhakka, N., Kjems, J., de Graan, P. N. E. & Pasterkamp, R. J. (2024). Compartment-specific small non-coding RNA changes and nucleolar defects in human mesial temporal lobe epilepsy. Acta Neuropathologica, 148(1), Article 61. https://doi.org/10.1007/s00401-024-02817-8

Valero, J., Civit, L., Dupont, D. M., Selnihhin, D., Reinert, L. S., Idorn, M., Israels, B. A., Bednarz, A. M., Bus, C., Asbach, B., Peterhoff, D., Pedersen, F. S., Birkedal, V., Wagner, R., Paludan, S. R. & Kjems, J. (2021). A serum-stable RNA aptamer specific for SARS-CoV-2 neutralizes viral entry. Proceedings of the National Academy of Sciences (PNAS), 118(50), Article e2112942118. https://doi.org/10.1073/pnas.2112942118

Uhd, J., Okholm, A., Kjems, J. & Astakhova, K. (2017). Amplification-free liquid biopsy by fluorescence approach. In Biotech, Biomaterials and Biomedical - TechConnect Briefs 2017 (Vol. 3, pp. 106-109). TechConnect. https://briefs.techconnect.org/wp-content/volumes/TCB2017v3/pdf/762.pdf

Torarinsson, E., Yao, Z., Wiklund, E. D., Bramsen, J. B., Hansen, C. A., Kjems, J., Tommerup, N., Ruzzo, W. L. & Gorodkin, J. (2008). Comparative genomics beyond sequence-based alignments: RNA structures in the ENCODE regions. Genome Research, 18(2), 242-251. https://doi.org/10.1101/gr.6887408

Displaying results 51 to 55 out of 443

Full list of publications

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Lab website

Revised 08.12.2025

Rikke Ploug Frydenberg