JØRGEN KJEMS: Nanomedicine

There are three main focus areas in the Kjems lab:

a) The understanding of how small non-coding RNA and circular RNA contribute to cell maintenance and disease development with a primary aim of defining new targets for disease intervention.

b) The creation of novel bioimaging and delivery systems for gene medicine including siRNA, miRNA mimics, antimiRs (antisense targeting microRNA) with a specific focus on inflammation, cancer, influenza, and regeneration of damaged tissue (tissue engineering).

c) Design and construction of functionalized self assembled DNA and RNA nanostructures capable of complex biosensing, coupled with controlled action e.g. drug release, enzyme activation, and receptor signaling.

In CellPAT, Jørgen Kjems contributes with key expertises in applied nanotechnology including biomolecular design, bioconjugation, cell delivery and tissue engineering as well as the more basic molecular biology fields of gene expression and cellular growth and development.

Recent publications

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Verhoef, K., Bilodeau, P. S., nullWamelJ.L.B., V., Kjems, J., Stoltzfus, C. M. & Berkhout, B. (2001). Repair of a Rev-minus HIV-1 mutant by activation of a cryptic splice site. J. Virol., 75, 3495-3500.

Verboom, K., Everaert, C., Bolduc, N., Livak, K. J., Yigit, N., Rombaut, D., Anckaert, J., Lee, S., Venø, M. T., Kjems, J., Speleman, F., Mestdagh, P. & Vandesompele, J. (2019). SMARTer single cell total RNA sequencing. Nucleic Acids Research, 47(16), Article e93. https://doi.org/10.1093/nar/gkz535

Venø, M. T., Bramsen, J. B., Bendixen, C., Panitz, F., Holm, I. E., Öhman, M. & Kjems, J. (2012). Spatio-temporal regulation of ADAR editing during development in porcine neural tissues. RNA Biology, 9(8), 1054-1065. https://doi.org/10.4161/rna.21082

Venø, M. T., Hansen, T. B., Venø, S. T., Clausen, B. H., Grebing, M., Finsen, B., Holm, I. E. & Kjems, J. (2015). Spatio-temporal regulation of circular RNA expression during porcine embryonic brain development. Genome Biology, 16, Article 16:245. https://doi.org/10.1186/s13059-015-0801-3

Venø, M. T., Reschke, C. R., Morris, G., Connolly, N. M. C., Su, J., Yan, Y., Engel, T., Jimenez-Mateos, E. M., Harder, L. M., Pultz, D., Haunsberger, S. J., Pal, A., Heller, J. P., Campbell, A., Langa, E., Brennan, G. P., Conboy, K., Richardson, A., Norwood, B. A. ... Henshall, D. C. (2020). A systems approach delivers a functional microRNA catalog and expanded targets for seizure suppression in temporal lobe epilepsy. Proceedings of the National Academy of Sciences (PNAS), 117(27), 15977-15988. https://doi.org/10.1073/pnas.1919313117

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Revised 08.12.2025

Rikke Ploug Frydenberg