JØRGEN KJEMS: Nanomedicine

There are three main focus areas in the Kjems lab:

a) The understanding of how small non-coding RNA and circular RNA contribute to cell maintenance and disease development with a primary aim of defining new targets for disease intervention.

b) The creation of novel bioimaging and delivery systems for gene medicine including siRNA, miRNA mimics, antimiRs (antisense targeting microRNA) with a specific focus on inflammation, cancer, influenza, and regeneration of damaged tissue (tissue engineering).

c) Design and construction of functionalized self assembled DNA and RNA nanostructures capable of complex biosensing, coupled with controlled action e.g. drug release, enzyme activation, and receptor signaling.

In CellPAT, Jørgen Kjems contributes with key expertises in applied nanotechnology including biomolecular design, bioconjugation, cell delivery and tissue engineering as well as the more basic molecular biology fields of gene expression and cellular growth and development.

Recent publications

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Bobbili, M. R., Görgens, A., Yan, Y., Vogt, S., Gupta, D., Corso, G., Barbaria, S., Patrioli, C., Weilner, S., Pultar, M., Jacak, J., Hackl, M., Schosserer, M., Grillari, R., Kjems, J., Andaloussi, S. E. L. & Grillari, J. (2024). Snorkel-tag based affinity chromatography for recombinant extracellular vesicle purification. Journal of Extracellular Vesicles, 13(10), Article e12523. https://doi.org/10.1002/jev2.12523

Olesen, J. R., Kjems, J. & Besenbacher, F. (2006). Småt blir' godt: Nanomedicin i fremtidens sundhedssektor. Lægen i Midten, (5), 31.

Verboom, K., Everaert, C., Bolduc, N., Livak, K. J., Yigit, N., Rombaut, D., Anckaert, J., Lee, S., Venø, M. T., Kjems, J., Speleman, F., Mestdagh, P. & Vandesompele, J. (2019). SMARTer single cell total RNA sequencing. Nucleic Acids Research, 47(16), Article e93. https://doi.org/10.1093/nar/gkz535

Daugaard, I., Venø, M. T., Yan, Y., Kjeldsen, T. E., Lamy, P., Hager, H., Kjems, J. & Hansen, L. L. (2017). Small RNA sequencing reveals metastasis-related microRNAs in lung adenocarcinoma. OncoTarget, 8(16), 27047-27061. https://doi.org/10.18632/oncotarget.15968

Mortensen, M. R., Skovsgaard, M. B., Okholm, A. H., Scavenius, C., Dupont, D. M., Rosen, C. B., Enghild, J. J., Kjems, J. & Gothelf, K. V. (2018). Small-Molecule Probes for Affinity-Guided Introduction of Biocompatible Handles on Metal-Binding Proteins. Bioconjugate Chemistry, 29(9), 3016–3025. https://doi.org/10.1021/acs.bioconjchem.8b00424

Displaying results 71 to 75 out of 434

Full list of publications

Group leader

Group members

Lab website

Revised 08.12.2025

Rikke Ploug Frydenberg