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PAPER: Synthesis and biophysical properties of (l)-aTNA based G-quadruplexes

Screenshot from the article "synthesis and biophysical proterties of (L)-aTNA based G-quadruplexes" published in Organic & Biomolecular Chemistry

Org Biomol Chem. 2016, doi: 10.1039/c5ob02525g

Kumar V, Gothelf KV

Danish National Research Foundation Center for DNA Nanotechnology, iNANO, , Aarhus University, 8000 Aarhus C, Denmark

Department of Chemistry, Aarhus University, 8000 Aarhus C, Denmark


Novel G-quadruplex structures are constructed by acyclic (l)-threninol nucleic acid and their synthesis and biophysical properties are described. Pyrene excimer fluorescence and circular dichroism (CD) data revealed that four strands of aTNA are oriented in antiparallel direction.