Distinguished iNANO Lecture: Biomolecular Nanodevices as Novel Tools for Structural and Synthetic Biology
Assoc. prof. Ebbe Sloth Andersen, iNANO & Dept. of Molecular Biology, Aarhus University
Info about event
iNANO AUD (1593-012), Gustav Wieds Vej 14, 8000 Aarhus C
Biomolecular Nanodevices as Novel Tools for Structural and Synthetic Biology
Rationally designed nanostructures and devices can be efficiently build using the self-assembling properties of biomolecules such as DNA, RNA and proteins. Introduced a decade ago, the DNA origami method provided novel molecular scaffolds to organize nanoparticles  and allowed the creation of dynamic nanoscale devices . In recent years progress have been made in designing RNA and protein nanostructures with well-defined geometries [3,4 ] which points towards expanded applications of designer molecules. Biophysical techniques have been instrumental in verifying the structure of the biomolecular nanostructures and have allowed the exploration and development of new design principles. In this talk I will focus on the application of cryo-electron microscopy (cryo-EM) in determining the 3-dimensional structure DNA origami nanostructures and, in turn, how DNA origami scaffolds can be used as tools for cryo-EM by organizing molecules of interest. In the last part of the talk I will introduce our on going research efforts to design RNA origami nanostructures  that can be produced during transcription by the RNA polymerase, and to use these as expressible nanostructures for applications in synthetic biology.
Host: Director & professor Jørgen Kjems, iNANO & Dept. of Molecular Biology and Genetics, Aarhus University