Specialized iNANO lecture by Chris Brasnett – University of Groningen
Simulating biomolecular condensation with MARTINI
Info about event
Time
Location
iNANO teaching room 1593-222
Organizer
Dr. Chris Brasnett – University of Groningen, the Netherlands
Simulating biomolecular condensation with MARTINI
Biomolecular condensates have recently attracted a great deal of interest as dynamic organisers of the interior of cells. Through liquid-liquid phase separation of constituent biomolecules, membraneless organelles can be formed and dissolved through a variety of physicochemical factors.
Condensates are known to provide essential functions for cellular processes, for example, the compartmentalisation of molecules for biochemical reactions. I will discuss how coarse grained simulations using the Martini force field can be used to shed light on a number of properties of biomolecular condensates, such as critical behaviour and molecular partitioning.