Professor Chunying Chen, National Center for Nanoscience and Technology of China

Nano-Bio Interfaces and Strategies for Vaccine Development based on Nanotechnology

An inconvenient hurdle in the practice of nanomedicine is the protein corona, a spontaneous collection of biomolecular species by nanoparticles in living systems. The protein corona is dynamic in composition and may entail improved water suspendability and compromised delivery and targeting to the nanoparticles. How do we “live with” and exploit the protein corona without significantly sacrificing the efficacy of nanomedicines in diagnosing and curing human diseases? This talk will introduce cancer mRNA vaccine, novel adjuvant in vaccine development based on nanotechnology. Understanding the intracellular behaviors of nanomedicines and morphology variation of subcellular architecture impacted by nanomaterial-biology (nano-bio) interactions would eventually guide the safe-by-design, manufacturing, and evaluation of nanomedicines for the clinical translation.

Short bio:
Chunying Chen is a professor at National Center for Nanoscience and Technology, China. She was elected as CAS Academician, AIMBE Fellow and RSC fellow. Her research interests including the analysis of nanoprotein corona, important biological effects such as stealth effect, far-reaching effect and transport-transformation-bioavailability chain, which has guided the application research of nanoadjuvants and drug delivery systems. She published over 400 peer-reviewed articles including Nature Nanotechnology, Nature Protocols, PNAS, JACS. She has received numerous awards, including National Natural Science Award, IUPAC Distinguished Women in Chemistry or Chemical Engineering, TWAS Chemistry Award, RSC Environment Prize, Chinese Young Female Scientists Award and so on. She is currently an Executive Editor of ACS Nano and editorial board members of several journals.